ID   HRP1_PLAFA              Reviewed;         332 AA.
AC   P05227;
DT   13-AUG-1987, integrated into UniProtKB/Swiss-Prot.
DT   13-AUG-1987, sequence version 1.
DT   25-MAY-2022, entry version 66.
DE   RecName: Full=Histidine-rich protein PFHRP-II;
DE   Flags: Precursor;
OS   Plasmodium falciparum.
OC   Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC   Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX   NCBI_TaxID=5833;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
RX   PubMed=3016741; DOI=10.1073/pnas.83.16.6065;
RA   Wellems T.E., Howard R.J.;
RT   "Homologous genes encode two distinct histidine-rich proteins in a cloned
RT   isolate of Plasmodium falciparum.";
RL   Proc. Natl. Acad. Sci. U.S.A. 83:6065-6069(1986).
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DR   EMBL; M13986; AAA51639.1; -; Genomic_DNA.
DR   EMBL; K03509; AAA51639.1; JOINED; mRNA.
DR   PIR; A25942; A25942.
DR   AlphaFoldDB; P05227; -.
DR   BindingDB; P05227; -.
DR   ChEMBL; CHEMBL1923; -.
DR   DrugCentral; P05227; -.
DR   ABCD; P05227; 1 sequenced antibody.
DR   VEuPathDB; PlasmoDB:Pf7G8-2_000246700; -.
DR   InterPro; IPR008779; Plasmodium_HRP.
DR   Pfam; PF05403; Plasmodium_HRP; 3.
PE   2: Evidence at transcript level;
KW   Malaria; Repeat; Signal.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000255"
FT   CHAIN           22..332
FT                   /note="Histidine-rich protein PFHRP-II"
FT                   /id="PRO_0000024540"
FT   REGION          62..332
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        64..78
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        79..332
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   332 AA;  35129 MW;  330842B99C5FCF5B CRC64;
     MVSFSKNKVL SAAVFASVLL LDNNNSAFNN NLCSKNAKGL NLNKRLLHET QAHVDDAHHA
     HHVADAHHAH HAHHAADAHH AHHAADAHHA HHAADAHHAH HAADAHHAHH AADAHHAHHA
     ADAHHAHHAA DAHHAHHAAD AHHAHHAADA HHAHHAAYAH HAHHASDAHH AADAHHAAYA
     HHAHHAADAH HAADAHHAAY AHHAHHAADA HHAADAHHAT DAHHAHHAAD AHHATDAHHA
     ADAHHAADAH HATDAHHAAD AHHATDAHHA ADAHHAADAH HATDSHHAHH AADAHHAAAH
     HATDAHHAAA HHATDAHHAA AHHEAATHCL RH