HRPA_HAEIN
ID HRPA_HAEIN Reviewed; 1304 AA.
AC P45018; P44108; P44109; P71368;
DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT 15-JUL-1998, sequence version 2.
DT 03-AUG-2022, entry version 141.
DE RecName: Full=ATP-dependent RNA helicase HrpA homolog;
DE EC=3.6.4.13;
GN Name=hrpA; OrderedLocusNames=HI_1070;
OS Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC Pasteurellaceae; Haemophilus.
OX NCBI_TaxID=71421;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
RX PubMed=7542800; DOI=10.1126/science.7542800;
RA Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F.,
RA Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M.,
RA McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D.,
RA Scott J.D., Shirley R., Liu L.-I., Glodek A., Kelley J.M., Weidman J.F.,
RA Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R.,
RA Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D.,
RA Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A.,
RA Small K.V., Fraser C.M., Smith H.O., Venter J.C.;
RT "Whole-genome random sequencing and assembly of Haemophilus influenzae
RT Rd.";
RL Science 269:496-512(1995).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND SEQUENCE REVISION.
RA White O., Clayton R.A., Kerlavage A.R., Fleischmann R.D.;
RL Submitted (SEP-1996) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC -!- SIMILARITY: Belongs to the DEAD box helicase family. DEAH subfamily.
CC {ECO:0000305}.
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DR EMBL; L42023; AAC22728.1; -; Genomic_DNA.
DR PIR; G64165; G64165.
DR PIR; I64019; I64019.
DR RefSeq; NP_439228.2; NC_000907.1.
DR AlphaFoldDB; P45018; -.
DR SMR; P45018; -.
DR STRING; 71421.HI_1070; -.
DR EnsemblBacteria; AAC22728; AAC22728; HI_1070.
DR KEGG; hin:HI_1070; -.
DR PATRIC; fig|71421.8.peg.1114; -.
DR eggNOG; COG1643; Bacteria.
DR HOGENOM; CLU_001832_3_3_6; -.
DR OMA; YERVTLY; -.
DR PhylomeDB; P45018; -.
DR Proteomes; UP000000579; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR GO; GO:0003724; F:RNA helicase activity; IEA:UniProtKB-EC.
DR GO; GO:0000462; P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IBA:GO_Central.
DR GO; GO:0006397; P:mRNA processing; IBA:GO_Central.
DR Gene3D; 3.40.50.300; -; 2.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR011709; DEAD-box_helicase_OB_fold.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR002464; DNA/RNA_helicase_DEAH_CS.
DR InterPro; IPR007502; Helicase-assoc_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR024590; HrpA_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR010222; RNA_helicase_HrpA.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF11898; DUF3418; 1.
DR Pfam; PF04408; HA2; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF07717; OB_NTP_bind; 1.
DR SMART; SM00382; AAA; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00847; HA2; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR TIGRFAMs; TIGR01967; DEAH_box_HrpA; 1.
DR PROSITE; PS00690; DEAH_ATP_HELICASE; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding; Helicase; Hydrolase; Nucleotide-binding; Reference proteome.
FT CHAIN 1..1304
FT /note="ATP-dependent RNA helicase HrpA homolog"
FT /id="PRO_0000055179"
FT DOMAIN 93..257
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00541"
FT DOMAIN 281..448
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00542"
FT MOTIF 203..206
FT /note="DEAH box"
FT BINDING 106..113
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00541"
SQ SEQUENCE 1304 AA; 149626 MW; 179B59B57FBA5867 CRC64;
MKNSSVKHTL TPLQQSLFSQ LNDIMLVDQR RLSARIHGIG KIKSQEAQQA VAAEIQQQIE
QARLRVEQRK SAVQNPIVFP ESLPVSQRKV EIQKLISEHQ VIVVAGETGS GKTTQLPKMC
LELGFGNLGM IGHTQPRRIA ARSVAARIAE ELETELGGLV GYKVRFNDQI SDNTQIKLMT
DGILLAEIQN DRFLNQYSCL IIDEAHERSL NNDFILGYLK QLLPRRRRDL KLIITSATID
VERFSKHFNN APIIEVSGRT YPVEVRYRPV VEEDDQDQLQ GILNAVDELQ AEGRGDILIF
MNGEREIRDT AEALQKQNLK HTEILPLFAR LSAQEQNKIF HPSGLNRIVL ATNVAETSLT
VPSIKYVIDP GTARISRYSY RTKVQRLPIE PISQASANQR KGRCGRVSEG ICIRLYSEED
FNSRPEFTDP EILRTNLASV ILQMTALGLD DIEAFPFVDA PDERHIQDGV KLLEELGAFE
TVQTKSGEKR LLTRVGRQLA QLPVDPRLAK MILSAVNFGC VYEMMIIVSA LSIQDPRERP
QEKQQASDEK HRRFADKKSD FLAFLNLWRY LQEQQKESSK NQFRRQCQKD FLNYLRIREW
QDIYHQIRLT VREMSLPINS EKAEYQQIHT ALLSGLLSHI GLKEAEKQQY LGARNAHFAI
FPNSVLFKKQ PKWVMAAELV ETSKLWGRMV AEIEPEWIEP LAEHLIKKSY SVPLWSKSRG
AVIADEKVTL YGVPIVAVRP VNYGAIDPTV SREIFIQSAL VEGGWNTKHK FFKENQRLVR
EVEELEHKSR RRDILVDDRT LFEFYDQRIG TEVVSQKHFD TWWKKAQQKD PELLNFEHSF
LINDDAEQVS KLDFPNFWHQ GNLKLKLTYQ FEPGTDADGV TVHIPLPLLN QVEMTGFDWQ
IPGLREELVI ALIKSLPKSY RRNFVPAPNY AQAFLSRAVP LEKPLLDTLI YELRRMTGVT
VEAEHWNWEQ IPSHLKMTFR VVDENGKKIA ESMNLDELKF NLKDRVQESI SAVADDGIEQ
SGLHIWSFAD LPQCYEQKQR GFSVKAFPAI VDEKDAVGIK LFETEFEQSV AMQQGLRRLL
LLNVPSPIKY LHEKLPNKAK LGLYFTPFGR VLDLIDDCIA CAVDKLIADF GGFVWDEAGF
EKLRDFVREN LNEVTVDIAQ KVEQILTLTY QLNQRLKGKM DFTMAFALSD IKSQLAGLVY
QGFVQKSGYD RLPDLQRYLQ AVDKRIDKLA QDVNRDRAAM LRVEQVQQAY QQLLAKLPKS
KPISDEVAEI RYMIEELRVS LFAQQLGTKY QISDKRIGNI ISQY
