ID   HRPA_PSESH              Reviewed;         108 AA.
AC   Q9F0B1; Q6L958;
DT   07-JUN-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 1.
DT   25-MAY-2022, entry version 55.
DE   RecName: Full=Hrp pili protein HrpA;
DE   AltName: Full=TTSS pilin HrpA;
GN   Name=hrpA;
OS   Pseudomonas savastanoi pv. phaseolicola (Pseudomonas syringae pv.
OS   phaseolicola).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC   Pseudomonadaceae; Pseudomonas.
OX   NCBI_TaxID=319;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=1302A / Race 4;
RX   PubMed=11134504; DOI=10.1073/pnas.98.1.289;
RA   Lee J., Kluesener B., Tsiamis G., Stevens C., Neyt C., Tampakaki A.P.,
RA   Panopoulos N.J., Noeller J., Weiler E.W., Cornelis G.R., Mansfield J.W.,
RA   Nuernberger T.;
RT   "HrpZPsph from the plant pathogen Pseudomonas syringae pv. phaseolicola
RT   binds to lipid bilayers and forms an ion-conducting pore in vitro.";
RL   Proc. Natl. Acad. Sci. U.S.A. 98:289-294(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=KZ2W, and NPS 3121;
RA   Inoue Y., Takikawa Y.;
RT   "Phylogenic analysis of DNA sequences around the hrpZ regions of
RT   Pseudomonas syringae.";
RL   Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=NPS 3121;
RX   AGRICOLA=IND43617657; DOI=10.1111/j.1364-3703.2004.00212.x;
RA   Gropp S.J., Guttman D.S.;
RT   "The PCR amplification and characterization of entire Pseudomonas syringae
RT   hrp/hrc clusters.";
RL   Mol. Plant Pathol. 5:137-140(2004).
RN   [4]
RP   TRANSCRIPTIONAL REGULATION, AND SUBCELLULAR LOCATION.
RC   STRAIN=1449B / Race 7, and 1488A / Race 6;
RX   PubMed=15553250; DOI=10.1094/mpmi.2004.17.11.1250;
RA   Thwaites R., Spanu P.D., Panopoulos N.J., Stevens C., Mansfield J.W.;
RT   "Transcriptional regulation of components of the type III secretion system
RT   and effectors in Pseudomonas syringae pv. phaseolicola.";
RL   Mol. Plant Microbe Interact. 17:1250-1258(2004).
CC   -!- FUNCTION: Major structural protein of the hrp pilus, which is a
CC       component of the type III secretion system (TTSS, Hrp secretion system)
CC       required for effector protein delivery, parasitism, and pathogenicity.
CC       The hrp pilus functions as a conduit for protein delivery into the host
CC       cell. Also, affects the expression of TTSS-associated genes. Required
CC       for full expression of genes that encode regulatory, secretion, and
CC       effector proteins of the TTSS. HrpA-mediated gene regulation apparently
CC       is through effect on the mRNA level of hrpR and hrpS (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:15553250}. Fimbrium
CC       {ECO:0000269|PubMed:15553250}. Note=Extracellular and secreted via type
CC       III secretion system.
CC   -!- INDUCTION: Expression enhanced by contact with host cell wall. Also
CC       regulated by HrpRS and HrpL. {ECO:0000269|PubMed:15553250}.
CC   -!- SIMILARITY: Belongs to the HrpA type 1 family. {ECO:0000305}.
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DR   EMBL; AF268940; AAF99291.1; -; Genomic_DNA.
DR   EMBL; AB112552; BAD20819.1; -; Genomic_DNA.
DR   EMBL; AB112553; BAD20823.1; -; Genomic_DNA.
DR   EMBL; AY530203; AAS20458.1; -; Genomic_DNA.
DR   RefSeq; WP_011167990.1; NZ_RBUR01000293.1.
DR   AlphaFoldDB; Q9F0B1; -.
DR   GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR   GO; GO:0009289; C:pilus; IEA:UniProtKB-SubCell.
DR   InterPro; IPR018581; T3SS_pilus_HrpA.
DR   Pfam; PF09589; HrpA_pilin; 1.
PE   2: Evidence at transcript level;
KW   Fimbrium; Secreted; Virulence.
FT   CHAIN           1..108
FT                   /note="Hrp pili protein HrpA"
FT                   /id="PRO_0000219573"
FT   REGION          41..72
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        41..58
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VARIANT         4
FT                   /note="M -> I (in strain: KZ2W)"
SQ   SEQUENCE   108 AA;  11191 MW;  B2B00707C118D34D CRC64;
     MNIMSSLTNA GRGVVNTVGG AAQGINSVKS SADRNIALTK NTGSTDSIDA TRSSISKGDA
     KSAELDGTAN EENGLLRETS MLAGFEDKKE ALSNQIVASK IRNSVVQF