ID   HRPX_PLALO              Reviewed;         351 AA.
AC   P04929;
DT   13-AUG-1987, integrated into UniProtKB/Swiss-Prot.
DT   13-AUG-1987, sequence version 1.
DT   25-MAY-2022, entry version 49.
DE   RecName: Full=Histidine-rich glycoprotein;
DE   Flags: Precursor;
OS   Plasmodium lophurae.
OC   Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC   Plasmodiidae; Plasmodium; Plasmodium (Giovannolaia).
OX   NCBI_TaxID=5853;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=6095114; DOI=10.1038/312616a0;
RA   Ravetch J.V., Feder R., Pavlovec A., Blobel G.;
RT   "Primary structure and genomic organization of the histidine-rich protein
RT   of the malaria parasite Plasmodium lophurae.";
RL   Nature 312:616-620(1984).
CC   -!- MISCELLANEOUS: In the intraerythrocytic stages of development of
CC       P.lophurae in ducks, there is a synthesis of a major protein that
CC       accumulates to comprise at least 50% of the cellular mass: the
CC       histidine rich protein.
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DR   EMBL; X01469; CAA25698.1; -; Genomic_DNA.
DR   PIR; A22692; KGZQHL.
DR   AlphaFoldDB; P04929; -.
PE   4: Predicted;
KW   Glycoprotein; Malaria; Repeat; Signal.
FT   SIGNAL          1..23
FT   PROPEP          24..47
FT                   /id="PRO_0000024542"
FT   CHAIN           48..351
FT                   /note="Histidine-rich glycoprotein"
FT                   /id="PRO_0000024543"
FT   REPEAT          59..74
FT                   /note="16-1"
FT   REPEAT          75..90
FT                   /note="16-2"
FT   REPEAT          91..107
FT                   /note="17-1"
FT   REPEAT          108..123
FT                   /note="17-2"
FT   REPEAT          124..138
FT                   /note="15-1"
FT   REPEAT          139..153
FT                   /note="15-2"
FT   REGION          57..351
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          59..90
FT                   /note="2 X 16 AA tandem repeats"
FT   REGION          91..123
FT                   /note="2 X 17 AA tandem repeats"
FT   REGION          124..153
FT                   /note="2 X 15 AA tandem repeats"
FT   REGION          173..351
FT                   /note="18 X 10 AA tandem repeats"
FT   COMPBIAS        57..91
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        92..351
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        40
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   351 AA;  44031 MW;  D19A48D47D890453 CRC64;
     MFTSLKKVAT FSFLVWISQY SGSNSCSSSL VKHIPQTGSN LTFDRVLVED TVHPEHLHEE
     HHHHHPEEHH EPHHEEHHHH HPEEHHEPHH EEHHHHHPHP HHHHHHHPPH HHHHLGHHHH
     HHHAAHHHHH EEHHHHHHAA HHHHHEEHHH HHHAAHHHPW FHHHHLGYHH HHAPHHHHHH
     HHAPHHHHHH HHAPHHHHHH HHAPHHHHHH HHAPHHHHHH HHGHHHHHHH HHGHHHHHHH
     HHGHHHHHHH HHDAHHHHHH HHDAHHHHHH HHDAHHHHHH HHDAHHHHHH HHDAHHHHHH
     HHDAHHHHHH HDAHHHHHHH HDAHHHHHHH HDAHHHHHHH HDAHHHHHHH H