ID   HRP_PLABE               Reviewed;         423 AA.
AC   Q08168;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   25-MAY-2022, entry version 92.
DE   RecName: Full=58 kDa phosphoprotein;
DE   AltName: Full=Heat shock-related protein;
DE            Short=HRP;
OS   Plasmodium berghei.
OC   Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC   Plasmodiidae; Plasmodium; Plasmodium (Vinckeia).
OX   NCBI_TaxID=5821;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 7-423.
RC   STRAIN=ANKA;
RX   PubMed=8341321; DOI=10.1016/0166-6851(93)90220-r;
RA   Uparanukraw P., Toyoshima T., Aikawa M., Kumar N.;
RT   "Molecular cloning and localization of an abundant novel protein of
RT   Plasmodium berghei.";
RL   Mol. Biochem. Parasitol. 59:223-234(1993).
RN   [2]
RP   NUCLEOTIDE SEQUENCE OF 1-248.
RC   STRAIN=ANKA / HP 8417;
RA   Wiser M.F.;
RL   Submitted (JUL-1993) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   CHARACTERIZATION, AND SUBCELLULAR LOCATION.
RX   PubMed=9010839; DOI=10.1016/s0166-6851(96)02743-0;
RA   Wiser M.F., Jennings G.J., Uparanukraw P., van Belkum A., van Doorn L.J.,
RA   Kumar N.;
RT   "Further characterization of a 58 kDa Plasmodium berghei phosphoprotein as
RT   a cochaperone.";
RL   Mol. Biochem. Parasitol. 83:25-33(1996).
CC   -!- FUNCTION: May play a role in protein folding or protein-protein
CC       interactions. May act as a co-chaperone.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:9010839}.
CC   -!- DEVELOPMENTAL STAGE: Present in all the different life cycle stages.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAC37293.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; L04508; AAC37293.1; ALT_INIT; Genomic_DNA.
DR   EMBL; L21710; AAC37300.1; -; mRNA.
DR   PIR; T10455; T10455.
DR   AlphaFoldDB; Q08168; -.
DR   SMR; Q08168; -.
DR   VEuPathDB; PlasmoDB:PBANKA_1242300; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR   CDD; cd14438; Hip_N; 1.
DR   Gene3D; 1.25.40.10; -; 1.
DR   InterPro; IPR034649; Hip_N.
DR   InterPro; IPR006636; STI1_HS-bd.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   InterPro; IPR019734; TPR_repeat.
DR   Pfam; PF18253; HipN; 1.
DR   SMART; SM00727; STI1; 1.
DR   SMART; SM00028; TPR; 2.
DR   SUPFAM; SSF48452; SSF48452; 1.
DR   PROSITE; PS50293; TPR_REGION; 1.
PE   1: Evidence at protein level;
KW   Chaperone; Cytoplasm; Repeat; TPR repeat.
FT   CHAIN           1..423
FT                   /note="58 kDa phosphoprotein"
FT                   /id="PRO_0000106343"
FT   REPEAT          113..146
FT                   /note="TPR 1"
FT   REPEAT          147..180
FT                   /note="TPR 2"
FT   REPEAT          181..214
FT                   /note="TPR 3"
FT   DOMAIN          361..423
FT                   /note="STI1"
FT   REGION          46..82
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          260..301
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          292..362
FT                   /note="19 X 3-4 AA approximate repeats"
FT   COMPBIAS        59..82
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        260..280
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        25
FT                   /note="K -> G (in Ref. 1)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        77
FT                   /note="Missing (in Ref. 1; AAC37293)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   423 AA;  47759 MW;  FAF7002202D5C13A CRC64;
     MDIEKIEDLK KFVASCEENP SILLKPELSF FKDFIESFGG KIKKDKMGYE KMKSEDSTEE
     KSDEEEEDEE EEEEEEEDDD PEKLELIKEE AVECPPLAPI IEGELSEEQI EEICKLKEEA
     VDLVENKKYE EALEKYNKII SFGNPSAMIY TKRASILLNL KRPKACIRDC TEALNLNVDS
     ANAYKIRAKA YRYLGKWEFA HADMEQGQKI DYDENLWDMQ KLIQEKYKKI YEKRRYKINK
     EEEKQRLKRE KELKKKLAAK KKAEKMYKEN NKRENYDSDS SDSSYSEPDF SGDFPGGMPG
     GMPGMPGGMG GMGGMPGMPG GFPGMPGGMP GGMPGGMGGM PGMPGGMPGG MGGMPGMPGG
     MPDLNSPEMK ELFNNPQFFQ MMQNMMSNPD LINKYASDPK YKNIFENLKN SDLGGMMGEK
     PKP