ID   HRP_PLAFF               Reviewed;         221 AA.
AC   P04930;
DT   13-AUG-1987, integrated into UniProtKB/Swiss-Prot.
DT   13-AUG-1987, sequence version 1.
DT   25-MAY-2022, entry version 45.
DE   RecName: Full=Small histidine-alanine-rich protein;
DE            Short=SHARP;
DE   AltName: Full=Antigen 57;
DE   Flags: Precursor;
OS   Plasmodium falciparum (isolate FC27 / Papua New Guinea).
OC   Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC   Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX   NCBI_TaxID=5837;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=2415925; DOI=10.1093/nar/13.21.7837;
RA   Stahl H.-D., Kemp D.J., Crewther P.E., Scanlon D.B., Woodrow G.,
RA   Brown G.V., Bianco A.E., Anders R.F., Coppel R.L.;
RT   "Sequence of a cDNA encoding a small polymorphic histidine- and alanine-
RT   rich protein from Plasmodium falciparum.";
RL   Nucleic Acids Res. 13:7837-7846(1985).
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DR   EMBL; X03144; CAA26916.1; -; mRNA.
DR   PIR; A24117; KGZQHF.
DR   AlphaFoldDB; P04930; -.
DR   InterPro; IPR008779; Plasmodium_HRP.
DR   Pfam; PF05403; Plasmodium_HRP; 1.
PE   2: Evidence at transcript level;
KW   Malaria; Repeat; Signal.
FT   SIGNAL          1..21
FT   CHAIN           22..221
FT                   /note="Small histidine-alanine-rich protein"
FT                   /id="PRO_0000024539"
FT   REPEAT          57..59
FT                   /note="1-1"
FT   REPEAT          60..62
FT                   /note="1-2"
FT   REPEAT          63..65
FT                   /note="1-3; approximate"
FT   REPEAT          66..68
FT                   /note="1-4"
FT   REPEAT          69..74
FT                   /note="2-1"
FT   REPEAT          75..80
FT                   /note="2-2"
FT   REPEAT          81..86
FT                   /note="2-3"
FT   REPEAT          87..92
FT                   /note="2-4"
FT   REPEAT          93..98
FT                   /note="2-5"
FT   REPEAT          99..104
FT                   /note="2-6"
FT   REPEAT          105..110
FT                   /note="2-7"
FT   REPEAT          111..116
FT                   /note="2-8"
FT   REPEAT          117..122
FT                   /note="2-9"
FT   REPEAT          123..128
FT                   /note="2-10"
FT   REPEAT          129..134
FT                   /note="2-11"
FT   REPEAT          135..140
FT                   /note="2-12"
FT   REPEAT          141..146
FT                   /note="2-13; approximate"
FT   REPEAT          176..180
FT                   /note="3-1"
FT   REPEAT          181..185
FT                   /note="3-2"
FT   REPEAT          186..190
FT                   /note="3-3"
FT   REPEAT          191..195
FT                   /note="3-4"
FT   REPEAT          196..200
FT                   /note="3-5"
FT   REPEAT          201..205
FT                   /note="3-6"
FT   REPEAT          206..210
FT                   /note="3-7"
FT   REGION          52..141
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          57..68
FT                   /note="4 X 3 AA approximate tandem repeats of A-H-H"
FT   REGION          69..146
FT                   /note="13 X 6 AA approximate tandem repeats of A-H-H-A-A-N"
FT   REGION          176..210
FT                   /note="7 X 5 AA tandem repeats of H-H-D-[DG]-A"
FT   REGION          180..221
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        52..72
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        180..212
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   221 AA;  23580 MW;  B1C7D51F8CE2C01E CRC64;
     MVSFSKNKIL SAAVFASVLL LDNNNSEFNN NLFSKNAKGL NSNKRLLHES QAHAGDAHHA
     HHVADAHHAH HAANAHHAAN AHHAANAHHA ANAHHAANAH HAANAHHAAN AHHAANAHHA
     ANAHHAANAH HAANAHHAAN AHHAADANHG FHFNLHDNNS HTLHHAKANA CFDDSHHDDA
     HHDGAHHDDA HHDGAHHDGA HHDGAHHDGA HHNATTHHLH H