HRTA_STAA3
ID HRTA_STAA3 Reviewed; 221 AA.
AC Q2FED7;
DT 09-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT 21-MAR-2006, sequence version 1.
DT 03-AUG-2022, entry version 92.
DE RecName: Full=Putative hemin import ATP-binding protein HrtA;
DE EC=7.6.2.-;
GN Name=hrtA; OrderedLocusNames=SAUSA300_2306;
OS Staphylococcus aureus (strain USA300).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC Staphylococcus.
OX NCBI_TaxID=367830;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=USA300;
RX PubMed=16517273; DOI=10.1016/s0140-6736(06)68231-7;
RA Diep B.A., Gill S.R., Chang R.F., Phan T.H., Chen J.H., Davidson M.G.,
RA Lin F., Lin J., Carleton H.A., Mongodin E.F., Sensabaugh G.F.,
RA Perdreau-Remington F.;
RT "Complete genome sequence of USA300, an epidemic clone of community-
RT acquired meticillin-resistant Staphylococcus aureus.";
RL Lancet 367:731-739(2006).
CC -!- FUNCTION: Part of the ABC transporter complex hrt involved in hemin
CC import. Responsible for energy coupling to the transport system (By
CC similarity). {ECO:0000250}.
CC -!- SUBUNIT: The complex is composed of two ATP-binding proteins (HrtA),
CC two transmembrane proteins (HrtB) and a solute-binding protein.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Peripheral membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the ABC transporter superfamily. HrtA family.
CC {ECO:0000305}.
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DR EMBL; CP000255; ABD21476.1; -; Genomic_DNA.
DR RefSeq; WP_001229911.1; NZ_CP027476.1.
DR AlphaFoldDB; Q2FED7; -.
DR SMR; Q2FED7; -.
DR EnsemblBacteria; ABD21476; ABD21476; SAUSA300_2306.
DR KEGG; saa:SAUSA300_2306; -.
DR HOGENOM; CLU_000604_1_22_9; -.
DR OMA; PTRGHID; -.
DR Proteomes; UP000001939; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR CDD; cd03255; ABC_MJ0796_LolCDE_FtsE; 1.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017911; MacB_ATP-bd.
DR InterPro; IPR027417; P-loop_NTPase.
DR Pfam; PF00005; ABC_tran; 1.
DR SMART; SM00382; AAA; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 1.
PE 3: Inferred from homology;
KW ATP-binding; Cell membrane; Membrane; Nucleotide-binding; Translocase;
KW Transport.
FT CHAIN 1..221
FT /note="Putative hemin import ATP-binding protein HrtA"
FT /id="PRO_0000270136"
FT DOMAIN 3..221
FT /note="ABC transporter"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT BINDING 39..46
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
SQ SEQUENCE 221 AA; 24626 MW; 88CE0C08FC09F703 CRC64;
MALVVEDIVK NFGEGLSETK VLKGINFEVE QGEFVILNGA SGSGKTTLLT ILGGLLSQTS
GTVLYNDAPL FDKQHRPSDL RLEDIGFIFQ SSHLVPYLKV IEQLTLVGQE AGMTKQQSST
RAIQLLKNIG LEDRLNVYPH QLSGGEKQRV AIMRAFMNNP KIILADEPTA SLDADRATKV
VEMIRQQIKE QQMIGIMITH DRRLFEYADR VIELEDGKIT D