ID   HRTA_STAAM              Reviewed;         221 AA.
AC   Q99RR8;
DT   09-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 1.
DT   03-AUG-2022, entry version 131.
DE   RecName: Full=Putative hemin import ATP-binding protein HrtA;
DE            EC=7.6.2.-;
GN   Name=hrtA; OrderedLocusNames=SAV2359;
OS   Staphylococcus aureus (strain Mu50 / ATCC 700699).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=158878;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Mu50 / ATCC 700699;
RX   PubMed=11418146; DOI=10.1016/s0140-6736(00)04403-2;
RA   Kuroda M., Ohta T., Uchiyama I., Baba T., Yuzawa H., Kobayashi I., Cui L.,
RA   Oguchi A., Aoki K., Nagai Y., Lian J.-Q., Ito T., Kanamori M.,
RA   Matsumaru H., Maruyama A., Murakami H., Hosoyama A., Mizutani-Ui Y.,
RA   Takahashi N.K., Sawano T., Inoue R., Kaito C., Sekimizu K., Hirakawa H.,
RA   Kuhara S., Goto S., Yabuzaki J., Kanehisa M., Yamashita A., Oshima K.,
RA   Furuya K., Yoshino C., Shiba T., Hattori M., Ogasawara N., Hayashi H.,
RA   Hiramatsu K.;
RT   "Whole genome sequencing of meticillin-resistant Staphylococcus aureus.";
RL   Lancet 357:1225-1240(2001).
CC   -!- FUNCTION: Part of the ABC transporter complex hrt involved in hemin
CC       import. Responsible for energy coupling to the transport system (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: The complex is composed of two ATP-binding proteins (HrtA),
CC       two transmembrane proteins (HrtB) and a solute-binding protein.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Peripheral membrane
CC       protein {ECO:0000305}.
CC   -!- INDUCTION: Highly induced by hemin.
CC   -!- SIMILARITY: Belongs to the ABC transporter superfamily. HrtA family.
CC       {ECO:0000305}.
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DR   EMBL; BA000017; BAB58521.1; -; Genomic_DNA.
DR   RefSeq; WP_001229920.1; NC_002758.2.
DR   AlphaFoldDB; Q99RR8; -.
DR   SMR; Q99RR8; -.
DR   PaxDb; Q99RR8; -.
DR   EnsemblBacteria; BAB58521; BAB58521; SAV2359.
DR   KEGG; sav:SAV2359; -.
DR   HOGENOM; CLU_000604_1_22_9; -.
DR   OMA; PTRGHID; -.
DR   PhylomeDB; Q99RR8; -.
DR   BioCyc; SAUR158878:SAV_RS12855-MON; -.
DR   Proteomes; UP000002481; Chromosome.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   CDD; cd03255; ABC_MJ0796_LolCDE_FtsE; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR   InterPro; IPR017911; MacB_ATP-bd.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   Pfam; PF00005; ABC_tran; 1.
DR   SMART; SM00382; AAA; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS50893; ABC_TRANSPORTER_2; 1.
PE   2: Evidence at transcript level;
KW   ATP-binding; Cell membrane; Membrane; Nucleotide-binding; Translocase;
KW   Transport.
FT   CHAIN           1..221
FT                   /note="Putative hemin import ATP-binding protein HrtA"
FT                   /id="PRO_0000270132"
FT   DOMAIN          3..221
FT                   /note="ABC transporter"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT   BINDING         39..46
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
SQ   SEQUENCE   221 AA;  24625 MW;  8E6C88C81AAD37E7 CRC64;
     MALVVKDIVK NFGEGLSETK VLKGINFEVE QGEFVILNGA SGSGKTTLLT ILGGLLSQTS
     GTVLYNDAPL FDKQHRPSDL RLEDIGFIFQ SSHLVPYLKV IEQLTLVGQE AGMTKQQSST
     RAIQLLKNIG LEDRLNVYPH QLSGGEKQRV AIMRAFMNNP KIILADEPTA SLDADRATKV
     VEMIRQQIKE QQMIGIMITH DRRLFEYADR VIELEDGKIT D