HRTA_STAAR
ID HRTA_STAAR Reviewed; 221 AA.
AC Q6GE75;
DT 09-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT 19-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 116.
DE RecName: Full=Putative hemin import ATP-binding protein HrtA;
DE EC=7.6.2.-;
GN Name=hrtA; OrderedLocusNames=SAR2445;
OS Staphylococcus aureus (strain MRSA252).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC Staphylococcus.
OX NCBI_TaxID=282458;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MRSA252;
RX PubMed=15213324; DOI=10.1073/pnas.0402521101;
RA Holden M.T.G., Feil E.J., Lindsay J.A., Peacock S.J., Day N.P.J.,
RA Enright M.C., Foster T.J., Moore C.E., Hurst L., Atkin R., Barron A.,
RA Bason N., Bentley S.D., Chillingworth C., Chillingworth T., Churcher C.,
RA Clark L., Corton C., Cronin A., Doggett J., Dowd L., Feltwell T., Hance Z.,
RA Harris B., Hauser H., Holroyd S., Jagels K., James K.D., Lennard N.,
RA Line A., Mayes R., Moule S., Mungall K., Ormond D., Quail M.A.,
RA Rabbinowitsch E., Rutherford K.M., Sanders M., Sharp S., Simmonds M.,
RA Stevens K., Whitehead S., Barrell B.G., Spratt B.G., Parkhill J.;
RT "Complete genomes of two clinical Staphylococcus aureus strains: evidence
RT for the rapid evolution of virulence and drug resistance.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:9786-9791(2004).
CC -!- FUNCTION: Part of the ABC transporter complex hrt involved in hemin
CC import. Responsible for energy coupling to the transport system (By
CC similarity). {ECO:0000250}.
CC -!- SUBUNIT: The complex is composed of two ATP-binding proteins (HrtA),
CC two transmembrane proteins (HrtB) and a solute-binding protein.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Peripheral membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the ABC transporter superfamily. HrtA family.
CC {ECO:0000305}.
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DR EMBL; BX571856; CAG41427.1; -; Genomic_DNA.
DR RefSeq; WP_001229922.1; NC_002952.2.
DR AlphaFoldDB; Q6GE75; -.
DR SMR; Q6GE75; -.
DR KEGG; sar:SAR2445; -.
DR HOGENOM; CLU_000604_1_22_9; -.
DR OMA; PTRGHID; -.
DR OrthoDB; 1181903at2; -.
DR Proteomes; UP000000596; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR CDD; cd03255; ABC_MJ0796_LolCDE_FtsE; 1.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017911; MacB_ATP-bd.
DR InterPro; IPR027417; P-loop_NTPase.
DR Pfam; PF00005; ABC_tran; 1.
DR SMART; SM00382; AAA; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 1.
PE 3: Inferred from homology;
KW ATP-binding; Cell membrane; Membrane; Nucleotide-binding; Translocase;
KW Transport.
FT CHAIN 1..221
FT /note="Putative hemin import ATP-binding protein HrtA"
FT /id="PRO_0000270130"
FT DOMAIN 3..221
FT /note="ABC transporter"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT BINDING 39..46
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
SQ SEQUENCE 221 AA; 24642 MW; B493A39419BE9E09 CRC64;
MALVVKDIVK NFGEGLSETK VLKGINFEVE QGEFVILNGA SGSGKTTLLT ILGGLLSQTS
GTVLYNDAPL FDKQHRSSDL RLEDIGFIFQ SSHLVPYLKV IEQLTLVGQE AGMTKQQSSK
RAIQLLKNIG LEDRLNVYPH QLSGGEKQRV AIMRAFMNNP KIILADEPTA SLDADRATKV
VEMIRQQIKE QQMIGIMITH DRRLFEYADR VIELEDGKIT D