ID   HRTA_STAEQ              Reviewed;         222 AA.
AC   Q5HLN4;
DT   09-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT   15-FEB-2005, sequence version 1.
DT   03-AUG-2022, entry version 107.
DE   RecName: Full=Putative hemin import ATP-binding protein HrtA;
DE            EC=7.6.2.-;
GN   Name=hrtA; OrderedLocusNames=SERP1951;
OS   Staphylococcus epidermidis (strain ATCC 35984 / RP62A).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=176279;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 35984 / RP62A;
RX   PubMed=15774886; DOI=10.1128/jb.187.7.2426-2438.2005;
RA   Gill S.R., Fouts D.E., Archer G.L., Mongodin E.F., DeBoy R.T., Ravel J.,
RA   Paulsen I.T., Kolonay J.F., Brinkac L.M., Beanan M.J., Dodson R.J.,
RA   Daugherty S.C., Madupu R., Angiuoli S.V., Durkin A.S., Haft D.H.,
RA   Vamathevan J.J., Khouri H., Utterback T.R., Lee C., Dimitrov G., Jiang L.,
RA   Qin H., Weidman J., Tran K., Kang K.H., Hance I.R., Nelson K.E.,
RA   Fraser C.M.;
RT   "Insights on evolution of virulence and resistance from the complete genome
RT   analysis of an early methicillin-resistant Staphylococcus aureus strain and
RT   a biofilm-producing methicillin-resistant Staphylococcus epidermidis
RT   strain.";
RL   J. Bacteriol. 187:2426-2438(2005).
CC   -!- FUNCTION: Part of the ABC transporter complex hrt involved in hemin
CC       import. Responsible for energy coupling to the transport system (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: The complex is composed of two ATP-binding proteins (HrtA),
CC       two transmembrane proteins (HrtB) and a solute-binding protein.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Peripheral membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the ABC transporter superfamily. HrtA family.
CC       {ECO:0000305}.
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DR   EMBL; CP000029; AAW52833.1; -; Genomic_DNA.
DR   RefSeq; WP_001831526.1; NC_002976.3.
DR   AlphaFoldDB; Q5HLN4; -.
DR   SMR; Q5HLN4; -.
DR   STRING; 176279.SERP1951; -.
DR   EnsemblBacteria; AAW52833; AAW52833; SERP1951.
DR   GeneID; 50017965; -.
DR   KEGG; ser:SERP1951; -.
DR   eggNOG; COG1136; Bacteria.
DR   HOGENOM; CLU_000604_1_22_9; -.
DR   OMA; PTRGHID; -.
DR   OrthoDB; 1181903at2; -.
DR   Proteomes; UP000000531; Chromosome.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   CDD; cd03255; ABC_MJ0796_LolCDE_FtsE; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR   InterPro; IPR017911; MacB_ATP-bd.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   Pfam; PF00005; ABC_tran; 1.
DR   SMART; SM00382; AAA; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS50893; ABC_TRANSPORTER_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Cell membrane; Membrane; Nucleotide-binding;
KW   Reference proteome; Translocase; Transport.
FT   CHAIN           1..222
FT                   /note="Putative hemin import ATP-binding protein HrtA"
FT                   /id="PRO_0000270138"
FT   DOMAIN          3..222
FT                   /note="ABC transporter"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT   BINDING         39..46
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
SQ   SEQUENCE   222 AA;  24588 MW;  9E7C0EE7D35F0B0E CRC64;
     MGLVVKDISK TFGEKTSKTE VLKDINFEVK DGEFIILNGA SGSGKTTLLT ILGGLLSQTS
     GDVVYEGKSL FERHTNKAHL RLNDIGFIFQ ASHLVPYLKV LDQLTLIGKE TGMSSKEAQA
     RAKELLTKIG LEEQLNSYPH MLSGGQQQRV AIMRALMNHP KIVLADEPTA SLDASRAQEV
     VEMIRKQIKA NQMIGIMITH DESLFKYADR IVQLYDGKIK NS