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HRTB_STAAR
ID   HRTB_STAAR              Reviewed;         351 AA.
AC   Q6GE74;
DT   09-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 81.
DE   RecName: Full=Putative hemin transport system permease protein HrtB;
GN   Name=hrtB; OrderedLocusNames=SAR2446;
OS   Staphylococcus aureus (strain MRSA252).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=282458;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MRSA252;
RX   PubMed=15213324; DOI=10.1073/pnas.0402521101;
RA   Holden M.T.G., Feil E.J., Lindsay J.A., Peacock S.J., Day N.P.J.,
RA   Enright M.C., Foster T.J., Moore C.E., Hurst L., Atkin R., Barron A.,
RA   Bason N., Bentley S.D., Chillingworth C., Chillingworth T., Churcher C.,
RA   Clark L., Corton C., Cronin A., Doggett J., Dowd L., Feltwell T., Hance Z.,
RA   Harris B., Hauser H., Holroyd S., Jagels K., James K.D., Lennard N.,
RA   Line A., Mayes R., Moule S., Mungall K., Ormond D., Quail M.A.,
RA   Rabbinowitsch E., Rutherford K.M., Sanders M., Sharp S., Simmonds M.,
RA   Stevens K., Whitehead S., Barrell B.G., Spratt B.G., Parkhill J.;
RT   "Complete genomes of two clinical Staphylococcus aureus strains: evidence
RT   for the rapid evolution of virulence and drug resistance.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:9786-9791(2004).
CC   -!- FUNCTION: Part of the ABC transporter complex hrt involved in hemin
CC       import. Responsible for the translocation of the substrate across the
CC       membrane (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: The complex is composed of two ATP-binding proteins (HrtA),
CC       two transmembrane proteins (HrtB) and a solute-binding protein.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the ABC-4 integral membrane protein family. HrtB
CC       subfamily. {ECO:0000305}.
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DR   EMBL; BX571856; CAG41428.1; -; Genomic_DNA.
DR   RefSeq; WP_000761409.1; NC_002952.2.
DR   AlphaFoldDB; Q6GE74; -.
DR   SMR; Q6GE74; -.
DR   KEGG; sar:SAR2446; -.
DR   HOGENOM; CLU_060907_1_0_9; -.
DR   OMA; KMNVQTL; -.
DR   OrthoDB; 768211at2; -.
DR   Proteomes; UP000000596; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR003838; ABC3_permease_dom.
DR   InterPro; IPR025857; MacB_PCD.
DR   Pfam; PF02687; FtsX; 1.
DR   Pfam; PF12704; MacB_PCD; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..351
FT                   /note="Putative hemin transport system permease protein
FT                   HrtB"
FT                   /id="PRO_0000270526"
FT   TRANSMEM        16..36
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        234..254
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        281..301
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        316..336
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   351 AA;  39573 MW;  937684BCFBC24B5A CRC64;
     MKLAIKEIMF YKFRYILITL IILLLSIMVL FISGLAQGLG RENISLFEHF DNDEYVVQKM
     KEPQIEKSQL SDTQQNQIKK VIHQESYKMN IQTLKLSNKE QDVITMNDVK QQRIQLKKGD
     YPKNAHEVAI NDKLAADNIR VGDRLHFKNN STSYRVSGIL NDTMYSHSSI VLLNDNGFNA
     LNKVNTAFYP VKNLTQQQRD ELNKINDVQV VNEKDLTDNI ASYQAEQAPL NMMIVSLFAI
     TAIVLSAFFY VMTIQKISQI GILKAIGIKT RHLLSALVLQ ILTLTIIGVG IAVIIIVGLS
     FMMPVTMPFY LTTQNILLMV GIFILVAILG ASLSFIKLFK VDPIEAIGGA E
 
 
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