HRTB_STAAR
ID HRTB_STAAR Reviewed; 351 AA.
AC Q6GE74;
DT 09-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT 19-JUL-2004, sequence version 1.
DT 25-MAY-2022, entry version 81.
DE RecName: Full=Putative hemin transport system permease protein HrtB;
GN Name=hrtB; OrderedLocusNames=SAR2446;
OS Staphylococcus aureus (strain MRSA252).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC Staphylococcus.
OX NCBI_TaxID=282458;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MRSA252;
RX PubMed=15213324; DOI=10.1073/pnas.0402521101;
RA Holden M.T.G., Feil E.J., Lindsay J.A., Peacock S.J., Day N.P.J.,
RA Enright M.C., Foster T.J., Moore C.E., Hurst L., Atkin R., Barron A.,
RA Bason N., Bentley S.D., Chillingworth C., Chillingworth T., Churcher C.,
RA Clark L., Corton C., Cronin A., Doggett J., Dowd L., Feltwell T., Hance Z.,
RA Harris B., Hauser H., Holroyd S., Jagels K., James K.D., Lennard N.,
RA Line A., Mayes R., Moule S., Mungall K., Ormond D., Quail M.A.,
RA Rabbinowitsch E., Rutherford K.M., Sanders M., Sharp S., Simmonds M.,
RA Stevens K., Whitehead S., Barrell B.G., Spratt B.G., Parkhill J.;
RT "Complete genomes of two clinical Staphylococcus aureus strains: evidence
RT for the rapid evolution of virulence and drug resistance.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:9786-9791(2004).
CC -!- FUNCTION: Part of the ABC transporter complex hrt involved in hemin
CC import. Responsible for the translocation of the substrate across the
CC membrane (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: The complex is composed of two ATP-binding proteins (HrtA),
CC two transmembrane proteins (HrtB) and a solute-binding protein.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the ABC-4 integral membrane protein family. HrtB
CC subfamily. {ECO:0000305}.
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DR EMBL; BX571856; CAG41428.1; -; Genomic_DNA.
DR RefSeq; WP_000761409.1; NC_002952.2.
DR AlphaFoldDB; Q6GE74; -.
DR SMR; Q6GE74; -.
DR KEGG; sar:SAR2446; -.
DR HOGENOM; CLU_060907_1_0_9; -.
DR OMA; KMNVQTL; -.
DR OrthoDB; 768211at2; -.
DR Proteomes; UP000000596; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR InterPro; IPR003838; ABC3_permease_dom.
DR InterPro; IPR025857; MacB_PCD.
DR Pfam; PF02687; FtsX; 1.
DR Pfam; PF12704; MacB_PCD; 1.
PE 3: Inferred from homology;
KW Cell membrane; Membrane; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..351
FT /note="Putative hemin transport system permease protein
FT HrtB"
FT /id="PRO_0000270526"
FT TRANSMEM 16..36
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 234..254
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 281..301
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 316..336
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 351 AA; 39573 MW; 937684BCFBC24B5A CRC64;
MKLAIKEIMF YKFRYILITL IILLLSIMVL FISGLAQGLG RENISLFEHF DNDEYVVQKM
KEPQIEKSQL SDTQQNQIKK VIHQESYKMN IQTLKLSNKE QDVITMNDVK QQRIQLKKGD
YPKNAHEVAI NDKLAADNIR VGDRLHFKNN STSYRVSGIL NDTMYSHSSI VLLNDNGFNA
LNKVNTAFYP VKNLTQQQRD ELNKINDVQV VNEKDLTDNI ASYQAEQAPL NMMIVSLFAI
TAIVLSAFFY VMTIQKISQI GILKAIGIKT RHLLSALVLQ ILTLTIIGVG IAVIIIVGLS
FMMPVTMPFY LTTQNILLMV GIFILVAILG ASLSFIKLFK VDPIEAIGGA E