HS110_CAEEL
ID HS110_CAEEL Reviewed; 776 AA.
AC Q05036;
DT 01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1994, sequence version 1.
DT 03-AUG-2022, entry version 152.
DE RecName: Full=Heat shock protein 110 {ECO:0000312|WormBase:C30C11.4};
GN Name=hsp-110 {ECO:0000312|WormBase:C30C11.4}; ORFNames=C30C11.4;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=7906398; DOI=10.1038/368032a0;
RA Wilson R., Ainscough R., Anderson K., Baynes C., Berks M., Bonfield J.,
RA Burton J., Connell M., Copsey T., Cooper J., Coulson A., Craxton M.,
RA Dear S., Du Z., Durbin R., Favello A., Fraser A., Fulton L., Gardner A.,
RA Green P., Hawkins T., Hillier L., Jier M., Johnston L., Jones M.,
RA Kershaw J., Kirsten J., Laisster N., Latreille P., Lightning J., Lloyd C.,
RA Mortimore B., O'Callaghan M., Parsons J., Percy C., Rifken L., Roopra A.,
RA Saunders D., Shownkeen R., Sims M., Smaldon N., Smith A., Smith M.,
RA Sonnhammer E., Staden R., Sulston J., Thierry-Mieg J., Thomas K.,
RA Vaudin M., Vaughan K., Waterston R., Watson A., Weinstock L.,
RA Wilkinson-Sproat J., Wohldman P.;
RT "2.2 Mb of contiguous nucleotide sequence from chromosome III of C.
RT elegans.";
RL Nature 368:32-38(1994).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [3]
RP DISRUPTION PHENOTYPE.
RX PubMed=19165329; DOI=10.1371/journal.pgen.1000350;
RA Wang J., Farr G.W., Hall D.H., Li F., Furtak K., Dreier L., Horwich A.L.;
RT "An ALS-linked mutant SOD1 produces a locomotor defect associated with
RT aggregation and synaptic dysfunction when expressed in neurons of
RT Caenorhabditis elegans.";
RL PLoS Genet. 5:E1000350-E1000350(2009).
CC -!- DISRUPTION PHENOTYPE: RNAi-mediated knockdown in a sod-1 mutant
CC background results in increased aggregation of denatured proteins in
CC neurons. {ECO:0000269|PubMed:19165329}.
CC -!- SIMILARITY: Belongs to the heat shock protein 70 family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; FO080722; CCD66159.1; -; Genomic_DNA.
DR PIR; S44784; S44784.
DR RefSeq; NP_498868.1; NM_066467.5.
DR AlphaFoldDB; Q05036; -.
DR SMR; Q05036; -.
DR BioGRID; 41399; 41.
DR DIP; DIP-24507N; -.
DR STRING; 6239.C30C11.4.1; -.
DR iPTMnet; Q05036; -.
DR World-2DPAGE; 0020:Q05036; -.
DR EPD; Q05036; -.
DR PaxDb; Q05036; -.
DR PeptideAtlas; Q05036; -.
DR EnsemblMetazoa; C30C11.4.1; C30C11.4.1; WBGene00016250.
DR GeneID; 176195; -.
DR KEGG; cel:CELE_C30C11.4; -.
DR UCSC; C30C11.4.1; c. elegans.
DR CTD; 176195; -.
DR WormBase; C30C11.4; CE00103; WBGene00016250; hsp-110.
DR eggNOG; KOG0103; Eukaryota.
DR GeneTree; ENSGT00940000168707; -.
DR HOGENOM; CLU_005965_5_1_1; -.
DR InParanoid; Q05036; -.
DR OMA; AYDRHFG; -.
DR OrthoDB; 406172at2759; -.
DR PhylomeDB; Q05036; -.
DR Reactome; R-CEL-3371453; Regulation of HSF1-mediated heat shock response.
DR PRO; PR:Q05036; -.
DR Proteomes; UP000001940; Chromosome III.
DR Bgee; WBGene00016250; Expressed in germ line (C elegans) and 4 other tissues.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0140662; F:ATP-dependent protein folding chaperone; IEA:InterPro.
DR GO; GO:0008340; P:determination of adult lifespan; IGI:WormBase.
DR GO; GO:0006457; P:protein folding; IBA:GO_Central.
DR GO; GO:0035966; P:response to topologically incorrect protein; IMP:WormBase.
DR Gene3D; 1.20.1270.10; -; 2.
DR Gene3D; 2.60.34.10; -; 1.
DR InterPro; IPR043129; ATPase_NBD.
DR InterPro; IPR018181; Heat_shock_70_CS.
DR InterPro; IPR029048; HSP70_C_sf.
DR InterPro; IPR029047; HSP70_peptide-bd_sf.
DR InterPro; IPR013126; Hsp_70_fam.
DR Pfam; PF00012; HSP70; 1.
DR SUPFAM; SSF100920; SSF100920; 1.
DR SUPFAM; SSF100934; SSF100934; 2.
DR SUPFAM; SSF53067; SSF53067; 2.
DR PROSITE; PS00329; HSP70_2; 1.
DR PROSITE; PS01036; HSP70_3; 1.
PE 3: Inferred from homology;
KW ATP-binding; Nucleotide-binding; Reference proteome.
FT CHAIN 1..776
FT /note="Heat shock protein 110"
FT /evidence="ECO:0000305"
FT /id="PRO_0000078299"
FT REGION 741..776
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 776 AA; 86897 MW; 20FA975FB649FA9C CRC64;
MSVLGFDIGN LNCYIGVARQ GGIEVITNDY SLHATPACVS FGPKDRSMGV AARQAVTTNI
KNTVINFKHL IGRKFSDPVA QRFIPFIPCK VVKLPNDDIG VQVSYLGEPH TFTPEQVLAA
LLTKLRTIVE SQLSDVKKVS DCVLAVPSYF TDVQRRAVLS AIQYAGLNSL RIVNETTAIA
LAYGIYKQDL PEEDAKSRNV VFLDIGHSST QASLVAFNRG KLQMVNTSYD LESGGIWFDA
LIREHFRKEF KTKYGIDAAT SPRPWLRLLD ECERVKKQMS ANQTPIPLNI ECFMEDKDVT
GKMQRQEFED LAAPIFNRIK QVLINLFADG VSIKPEEIDE IEIVGGSSRI PMIREIVKDL
FGKEPKTTMN QDEAVARGAA MQCAILSPTF RVREFAIKDT QPYRIRLSWN STGENGGEND
VFSPRDEVPF SKLVSLLRSG PFNVEAHYAQ PNVVPHNQVH IGSWKVNGAR PGADGGNQKV
KVKVRVNPDG IFTIASATMY EPRIVEEVPA EAMEVDGDAK TEAPAEPLEP VKKTKLVPVD
LEVIESIPVS YDVQKFHNLE LQMQESDARE KAKADAKNSL EEYVYEMRDK VSDQYAEFIT
PAAADEFRSV LTSTEDWLYD EGEDAERDVY EKRLSELKAV GTPVVERYRE SETRKPAFDS
FDQSIMRVRK AYEDYANGGP TYAHLDSKEM EKVINAIEDK KKWLDEARHK QETRSKTDAP
VVFTEEILQN KNVFENVVNP ILNKKKPAAP APPKKEEPQP AAGDQPQSQP GEMDVD
