HS178_ARATH
ID HS178_ARATH Reviewed; 157 AA.
AC Q9LNW0;
DT 03-NOV-2009, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 112.
DE RecName: Full=17.8 kDa class I heat shock protein;
DE AltName: Full=17.8 kDa heat shock protein;
DE Short=AtHsp17.8;
GN Name=HSP17.8; OrderedLocusNames=At1g07400; ORFNames=F22G5.25;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=11910074; DOI=10.1126/science.1071006;
RA Seki M., Narusaka M., Kamiya A., Ishida J., Satou M., Sakurai T.,
RA Nakajima M., Enju A., Akiyama K., Oono Y., Muramatsu M., Hayashizaki Y.,
RA Kawai J., Carninci P., Itoh M., Ishii Y., Arakawa T., Shibata K.,
RA Shinagawa A., Shinozaki K.;
RT "Functional annotation of a full-length Arabidopsis cDNA collection.";
RL Science 296:141-145(2002).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B.,
RA Feldmann K.A.;
RT "Full-length cDNA from Arabidopsis thaliana.";
RL Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP FUNCTION, DISRUPTION PHENOTYPE, INTERACTION WITH AKR2A, INDUCTION BY HEAT
RP SHOCK, AND TISSUE SPECIFICITY.
RC STRAIN=cv. Columbia;
RX PubMed=21730198; DOI=10.1104/pp.111.178681;
RA Kim D.H., Xu Z.-Y., Na Y.J., Yoo Y.-J., Lee J., Sohn E.-J., Hwang I.;
RT "Small heat shock protein Hsp17.8 functions as an AKR2A cofactor in the
RT targeting of chloroplast outer membrane proteins in Arabidopsis.";
RL Plant Physiol. 157:132-146(2011).
CC -!- FUNCTION: Cytosolic mediator for sorting and targeting of nascent
CC chloroplast outer envelope membrane (OEM) proteins to the chloroplast.
CC Functions as a AKR2A cofactor to facilitates the targeting of OEP7 to
CC chloroplasts. {ECO:0000269|PubMed:21730198}.
CC -!- SUBUNIT: Homodimer under normal physiological conditions. Aggregates in
CC high oligomeric complexes after heat shock. Binds to AKR2A and to
CC chloroplasts. {ECO:0000269|PubMed:21730198}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Expressed ubiquitously at low levels under normal
CC physiological conditions. {ECO:0000269|PubMed:21730198}.
CC -!- INDUCTION: Accumulates after heat shock. {ECO:0000269|PubMed:21730198}.
CC -!- DISRUPTION PHENOTYPE: Reduction of OEP7 targeting to plastids.
CC {ECO:0000269|PubMed:21730198}.
CC -!- SIMILARITY: Belongs to the small heat shock protein (HSP20) family.
CC {ECO:0000255|PROSITE-ProRule:PRU00285}.
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DR EMBL; AC022464; AAF79569.1; -; Genomic_DNA.
DR EMBL; CP002684; AEE28120.1; -; Genomic_DNA.
DR EMBL; AK118848; BAC43437.1; -; mRNA.
DR EMBL; BT005424; AAO63844.1; -; mRNA.
DR EMBL; AY086856; AAM63903.1; -; mRNA.
DR RefSeq; NP_172220.1; NM_100614.3.
DR AlphaFoldDB; Q9LNW0; -.
DR SMR; Q9LNW0; -.
DR BioGRID; 22493; 10.
DR IntAct; Q9LNW0; 10.
DR MINT; Q9LNW0; -.
DR STRING; 3702.AT1G07400.1; -.
DR PaxDb; Q9LNW0; -.
DR PRIDE; Q9LNW0; -.
DR ProteomicsDB; 230270; -.
DR EnsemblPlants; AT1G07400.1; AT1G07400.1; AT1G07400.
DR GeneID; 837252; -.
DR Gramene; AT1G07400.1; AT1G07400.1; AT1G07400.
DR KEGG; ath:AT1G07400; -.
DR Araport; AT1G07400; -.
DR TAIR; locus:2024997; AT1G07400.
DR eggNOG; KOG0710; Eukaryota.
DR HOGENOM; CLU_046737_5_0_1; -.
DR InParanoid; Q9LNW0; -.
DR OMA; YGRFERC; -.
DR OrthoDB; 1187096at2759; -.
DR PhylomeDB; Q9LNW0; -.
DR PRO; PR:Q9LNW0; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q9LNW0; baseline and differential.
DR Genevisible; Q9LNW0; AT.
DR GO; GO:0005737; C:cytoplasm; IDA:TAIR.
DR GO; GO:0043621; F:protein self-association; IDA:UniProtKB.
DR GO; GO:0051082; F:unfolded protein binding; IBA:GO_Central.
DR GO; GO:0071456; P:cellular response to hypoxia; HEP:TAIR.
DR GO; GO:0051259; P:protein complex oligomerization; IBA:GO_Central.
DR GO; GO:0006457; P:protein folding; IBA:GO_Central.
DR GO; GO:0009408; P:response to heat; IEP:UniProtKB.
DR GO; GO:0042542; P:response to hydrogen peroxide; IBA:GO_Central.
DR GO; GO:0006979; P:response to oxidative stress; IEP:TAIR.
DR GO; GO:0009651; P:response to salt stress; IBA:GO_Central.
DR Gene3D; 2.60.40.790; -; 1.
DR InterPro; IPR002068; A-crystallin/Hsp20_dom.
DR InterPro; IPR007052; CS_dom.
DR InterPro; IPR008978; HSP20-like_chaperone.
DR Pfam; PF00011; HSP20; 1.
DR SUPFAM; SSF49764; SSF49764; 1.
DR PROSITE; PS01031; SHSP; 1.
PE 1: Evidence at protein level;
KW Cytoplasm; Reference proteome; Stress response.
FT CHAIN 1..157
FT /note="17.8 kDa class I heat shock protein"
FT /id="PRO_0000387485"
FT DOMAIN 41..156
FT /note="sHSP"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00285"
SQ SEQUENCE 157 AA; 17828 MW; A27A9D2191ABB8E6 CRC64;
MSLIPSFFGN NRRSNSIFDP FSLDVWDPFK ELQFPSSLSG ETSAITNARV DWKETAEAHV
FKADLPGMKK EEVKVEIEDD SVLKISGERH VEKEEKQDTW HRVERSSGQF SRKFKLPENV
KMDQVKASME NGVLTVTVPK VEEAKKKAQV KSIDISG
