AP2A_PLAF7
ID AP2A_PLAF7 Reviewed; 3473 AA.
AC Q8I1N6; C0H4B6; Q8IFQ8;
DT 14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT 14-APR-2009, sequence version 2.
DT 23-FEB-2022, entry version 88.
DE RecName: Full=AP2/ERF domain-containing protein PFD0985w;
DE Short=ApiAP2;
GN ORFNames=PFD0985w;
OS Plasmodium falciparum (isolate 3D7).
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX NCBI_TaxID=36329;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=3D7;
RX PubMed=12368864; DOI=10.1038/nature01097;
RA Gardner M.J., Hall N., Fung E., White O., Berriman M., Hyman R.W.,
RA Carlton J.M., Pain A., Nelson K.E., Bowman S., Paulsen I.T., James K.D.,
RA Eisen J.A., Rutherford K.M., Salzberg S.L., Craig A., Kyes S., Chan M.-S.,
RA Nene V., Shallom S.J., Suh B., Peterson J., Angiuoli S., Pertea M.,
RA Allen J., Selengut J., Haft D., Mather M.W., Vaidya A.B., Martin D.M.A.,
RA Fairlamb A.H., Fraunholz M.J., Roos D.S., Ralph S.A., McFadden G.I.,
RA Cummings L.M., Subramanian G.M., Mungall C., Venter J.C., Carucci D.J.,
RA Hoffman S.L., Newbold C., Davis R.W., Fraser C.M., Barrell B.G.;
RT "Genome sequence of the human malaria parasite Plasmodium falciparum.";
RL Nature 419:498-511(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=3D7;
RX PubMed=12368867; DOI=10.1038/nature01095;
RA Hall N., Pain A., Berriman M., Churcher C.M., Harris B., Harris D.,
RA Mungall K.L., Bowman S., Atkin R., Baker S., Barron A., Brooks K.,
RA Buckee C.O., Burrows C., Cherevach I., Chillingworth C., Chillingworth T.,
RA Christodoulou Z., Clark L., Clark R., Corton C., Cronin A., Davies R.M.,
RA Davis P., Dear P., Dearden F., Doggett J., Feltwell T., Goble A.,
RA Goodhead I., Gwilliam R., Hamlin N., Hance Z., Harper D., Hauser H.,
RA Hornsby T., Holroyd S., Horrocks P., Humphray S., Jagels K., James K.D.,
RA Johnson D., Kerhornou A., Knights A., Konfortov B., Kyes S., Larke N.,
RA Lawson D., Lennard N., Line A., Maddison M., Mclean J., Mooney P.,
RA Moule S., Murphy L., Oliver K., Ormond D., Price C., Quail M.A.,
RA Rabbinowitsch E., Rajandream M.A., Rutter S., Rutherford K.M., Sanders M.,
RA Simmonds M., Seeger K., Sharp S., Smith R., Squares R., Squares S.,
RA Stevens K., Taylor K., Tivey A., Unwin L., Whitehead S., Woodward J.R.,
RA Sulston J.E., Craig A., Newbold C., Barrell B.G.;
RT "Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13.";
RL Nature 419:527-531(2002).
RN [3] {ECO:0000305}
RP SYNTHESIS OF 2083-2116, AND POSSIBLE CANDIDATE MALARIA EPITOPE.
RX PubMed=17653272; DOI=10.1371/journal.pone.0000645;
RA Villard V., Agak G.W., Frank G., Jafarshad A., Servis C., Nebie I.,
RA Sirima S.B., Felger I., Arevalo-Herrera M., Herrera S., Heitz F.,
RA Baecker V., Druilhe P., Kajava A.V., Corradin G.;
RT "Rapid identification of malaria vaccine candidates based on alpha-helical
RT coiled coil protein motif.";
RL PLoS ONE 2:E645-E645(2007).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255, ECO:0000305}.
CC -!- BIOTECHNOLOGY: Possible candidate for an effective malaria vaccine as
CC determined by epitope response in sera. {ECO:0000269|PubMed:17653272}.
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DR EMBL; AL844503; CAX63934.1; -; Genomic_DNA.
DR RefSeq; XP_002808665.1; XM_002808619.1.
DR BioGRID; 1207815; 16.
DR IntAct; Q8I1N6; 16.
DR STRING; 5833.PFD0985w; -.
DR PRIDE; Q8I1N6; -.
DR EnsemblProtists; CAX63934; CAX63934; PF3D7_0420300.
DR GeneID; 812480; -.
DR KEGG; pfa:PF3D7_0420300; -.
DR VEuPathDB; PlasmoDB:PF3D7_0420300; -.
DR HOGENOM; CLU_225509_0_0_1; -.
DR InParanoid; Q8I1N6; -.
DR OMA; NTIFPRN; -.
DR PhylomeDB; Q8I1N6; -.
DR Proteomes; UP000001450; Chromosome 4.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR InterPro; IPR001471; AP2/ERF_dom.
DR Pfam; PF00847; AP2; 1.
PE 1: Evidence at protein level;
KW DNA-binding; Merozoite; Nucleus; Reference proteome; Repeat; Transcription;
KW Transcription regulation.
FT CHAIN 1..3473
FT /note="AP2/ERF domain-containing protein PFD0985w"
FT /id="PRO_0000370212"
FT DNA_BIND 1957..2011
FT /note="AP2/ERF 1"
FT /evidence="ECO:0000255"
FT DNA_BIND 3268..3321
FT /note="AP2/ERF 2"
FT /evidence="ECO:0000255"
FT REGION 34..61
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 366..450
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 647..704
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 750..801
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1096..1196
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1300..1328
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1388..1418
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1773..1807
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1864..1898
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2068..2088
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2319..2343
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2387..2470
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2520..2584
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2609..2677
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2840..2860
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2881..2902
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2937..2960
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3369..3473
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 366..394
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 395..448
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 647..680
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 681..701
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 753..768
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 780..801
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1096..1153
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1300..1326
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1388..1414
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1864..1884
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2387..2401
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2408..2470
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2550..2584
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2612..2632
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2633..2661
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2662..2677
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2940..2960
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3369..3458
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3473 AA; 400169 MW; 88C229E8FB764AFE CRC64;
MSSCSLKCSI LPCVHIENNK NELHIENSKD ENGINNIIQE DPNNGHNDNI NNNDINNNNN
NNDNNNTIDN CICEKSSEEI SVHTEKCVHT VSLDVNVKDY NFEEFINSFE SDRRNILLNT
FNYFFYNNFG NLSEVKLKNG SIAHNYYYRK IALNIMNYDY EKEYRLYDDN RKINENSIIM
QSSAYCINEE NNSRPPLYED LFLKKTKITN IDDKNTKETI KKYKLPFEPN FYSNRFFFLD
NDMNGSLHQS TKNCTKYCNS FVVNYNNVSN CRKKKKKNTN PIIFNNINNN NNNNCDHVKP
LCCSYILRFE GPPPHFLIIK FDKVNRKAYI VKRVPVNKNI SFNLAKFIAE KYINMLRKNL
RKREIKMERK RNNNILNSRT KRGSSKKEHI ESNMENNNDN INNNDDDNNS NNNDDNNDNI
NNNNDNINNN NDNINNNNNS NNNDDDHLVC NNEIVPNNDC GTINNYSNNS STNYSSDYSF
SRNGEVLNEY NEEDLNNYLL NVDINSLPYE DYNSENYVNE KMCKNEYLDI DLENLIFSRD
AEKYIKFLSN VKIYFLKKLD DIDYFNTNCK DPFENKIVII VKMKYDICVK SKVFIFENMK
DLESEYEYVD IDENEKDNDN ICFKKGGDNT FVSLLNDDGH MNDANNNNNN NINCGDDGNN
NNNNNNSFDA DINSSSHVGN EPTGDKHETS KKEDTENEEA INAKTEGNFI TRNFFGLFKN
ECNANNGSDK EHLKEEDVCN KNTEEEEKMN IIKSDNVNNN NNNNNNNNNK KEKGKKKKEK
DADKNKKHKK KNIHDNNRKK KMTVNYRKKI IQFIRNNIYI NSYIYDCFEN KYTNNKFFKD
DVIIIRNTKS EEQEEEEHQL SYNVPYYIYE LNKFVFIKFM KFEKYINKNH DIANGYIKYL
LQSNIKCING YMIGIRWVPN VFAYEYYVYK ITEDVKSDFK KENEYMINNN MNGNNNNNNN
YNNDRYNNSR NCNTIYNYSL AIEKDSNEIT MKYLIDYENK VIDNVLCVLH EYYQTSLFTE
HCIFNLFKLV LLRVSLYIGV FNTKVITLDL DKAMYRMKKF SEPISMYDNY GFSENDNNML
LQGGDMLNME YLMNEVDNNN NNNNNNNNNN VNNISNNGTN LEENANNANN ANNPNNANNP
NNANNSNNAD YVNDYNDGYK EEDDDDEEED NNLTKKKDEE NTNYNINING ENMNMNSNMN
VEETFDETKN KNNLRITFSS VHFDNEGNKI SDNNIYENRA KHVSDSDMNN NNNNNNNTNI
NYPSSHDKYN ELFVKNEKCE SESYLPNKLK NKKKVSYNLD NTSISLRNKR SRDVGSNQNC
DHNNNSRGGG GGKCYGILKG EGDQFSIKYY STSANNTSST LINNKKEYYS NASDFSGTSH
LTAKHKYHLR SSNPQSTDNY SSEEYMQRSS MRTRGAERSA NRNKMLYKLM NKNGLIEPYW
WFFYNLYENA CIHEGSTITN NMNNNNNNIN GNNYNNYYFN KYNNNNNNNN NNNNNQKKGT
CGEDALNEEQ KRILEKKYKI NLLNHFCAKT EKLKIKYISM VHDIIYKKYM LLNNTIFPRN
LHESEILYTL FPHEPHTFMF LYTDDNFQYQ NEVFLKQITF SDNINWYHYP LGGQYNNIDL
YKNDVHDEKE RMVLHINDYY NGLGTSRYVI GKDFYVDHLI MGDSKDSTSN MLMSKNLKYS
NLPNYEKVRA NYREAHLLNE KEWKNIQNGG YYKTMLHLGE DMEHPYNFGV YQDPITSAYE
TNRNDYGFTN GILTNKILEP STSSAVTAAV VSNNTGTTQN NNKYGTNSNN NNNNNNNNNN
NNNNNKVFTF ERRRRGVKTN EYYDYFVTDK TLLGGKGKFH NVGEKRSVSN TNFGRNNRYY
DQMIGEDDDK KNTSDNDLTS LKRRKNGNSK RAKSNNLSNV KGYSIYNVEN NGDAQADNGN
NNVNNNLKGN MKGNNLNSNN IKSDVINHDD SLIPMGPLPT GVYFDSARKL WRCQWKENGK
FKTKGFSLIH YSTLEEARKQ CILYRCDVGN IPVKSEWLNP VYVRSSYFYS KKYSSSAHNA
TSAGTNYTTT AAHRELKTSS LNLSRLKEKT GVSQGVSTAN NNDNNVNNMD NNVNNVDNNV
NNVDNNLNNV DNNVNNNNVK SSGVEKGFMD GSSKGSNDEN YYVGQTNTIG NTNNNRYSTR
NNTAACAAAN DKGNEIDISI LQEFVSKNKE GGGVSVDGGG LLESALIERG LIESGLLDSG
SVNKNNMSLR LNSKNVMLGY NGEENNKKKK KKNIVEDNIK NMNNVENIKN IKDIKNVNNM
NNMNNMNNMN NYNFLFADKK NKNNNLNIGV KEEEKRRKQV DVVGDGSGTQ ALKRSKRSKS
NSKYKMDLRV GDLKEDFGKD MSNLINEEDI ENFRNTFNKE YLKSVLTNDN NNDGINNNND
DNNDDNNDDN NNNNNNNNKN NNKNSSNNKS NNNKKNYNNK NQNNNDNNND NGNNNNNNND
DNNDDNNIRS NSFFLDGKDI NNEYINNENF PNDIQSFFKF LNSKDVKDET KGKKYLDFKL
GNGLDGEEEG GGDYDEKEDD LLDENKNGLN FLNDDINNNN NNNNNNNNNN NNNNNNNNNN
NYNNDLFEAM KAFMKYNGNM MNNEKGELLY GKGGNNNNNN NNNNSGTYVK NKKSSKYDNK
SYGGDGIPRK EMKKERSKKS QKLLNSQVNE SSAPASNYKG GGVQFYMNLD TTNLLAASLM
TNNIINNLNN QGNGDNSHVN NNYNSNALGD MMKSSNKEGV GLSWSPSNMC PDIFFQDIQN
FINFAKRKER MNNGKEENGE GVQTNVRNTN NNAHIVGNNN NNNRNSGSII ENDVYENYLK
SLIVQYENEE KLKEKQYVQM NNNNNNNNNN NNNNNNNNVK YFQFGDKEEE EDKENLANLD
NDKLEKEKNG GGGVVSSSSS SPTTGFFQKY LNIFSKKKNG NESEEYMNNK SQVDNSKYVE
CGNGDKETND YNTRRKKKDE KFSVSSNALY DMSKVLNNNG LGSSMNSYNE AYKKNLNFLL
QKSSMNNNNM NNNNMNNNNM NNNNMNNNNM NNNNMNLNVY NNVTGDNNHM DNLDGGNNKG
LKKYNNNLGF NNMSEASLYE YFNFAALNNN NGSNILGQDR KKNGHISINT KSSSIFMNGM
HMNNYHNSVN NMNSFNSNSD HMEPKYDGYD DNMMRGMVER ALSSSLYFDN KQKGKESSNN
LNNNNNNNNN IINNMNHMNY INNNNNNIIN NMNHMNYINN NNNNNQYVDG QLTENEISNL
NVAGNVKSGK KKKGSTNDDE NINLIKQSLP KGIYYDHAKK LYRVQYIINN SIKTKGFSVK
KLGLAQAKIE AESFRNFCLE NGLLNSRKRR LNSPYNKKDE SFSMMPDNEE ILSNLLFLYN
SNMNNSMNKM SINNDGNNND GNNNDGNNND DNNNDDNNND DNNNDGNNND DNNNEGINND
DNNNEGINND DNNNEGINNN DDNNNNDDNN NEGINNDDNN DDNNNDNEMS QNE
