HS74L_MESAU
ID HS74L_MESAU Reviewed; 211 AA.
AC P86265;
DT 15-JUN-2010, integrated into UniProtKB/Swiss-Prot.
DT 15-JUN-2010, sequence version 1.
DT 03-AUG-2022, entry version 30.
DE RecName: Full=Heat shock 70 kDa protein 4L {ECO:0000250|UniProtKB:O95757};
DE AltName: Full=Heat shock 70-related protein APG-1 {ECO:0000250|UniProtKB:O95757};
DE AltName: Full=Osmotic stress protein 94 {ECO:0000250|UniProtKB:O95757};
DE Flags: Fragments;
GN Name=HSPA4L {ECO:0000250|UniProtKB:O95757};
GN Synonyms=APG1 {ECO:0000250|UniProtKB:O95757},
GN OSP94 {ECO:0000250|UniProtKB:O95757};
OS Mesocricetus auratus (Golden hamster).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC Cricetidae; Cricetinae; Mesocricetus.
OX NCBI_TaxID=10036;
RN [1]
RP IDENTIFICATION BY MASS SPECTROMETRY.
RX PubMed=20400973; DOI=10.1038/aja.2010.19;
RA Kameshwari D.B., Bhande S., Sundaram C.S., Kota V., Siva A.B., Shivaji S.;
RT "Glucose-regulated protein precursor (GRP78) and tumor rejection antigen
RT (GP96) are unique to hamster caput epididymal spermatozoa.";
RL Asian J. Androl. 12:344-355(2010).
CC -!- FUNCTION: Possesses chaperone activity in vitro where it inhibits
CC aggregation of citrate synthase. {ECO:0000250|UniProtKB:O95757}.
CC -!- SUBUNIT: Homodimer. {ECO:0000250|UniProtKB:O95757}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:O95757}. Nucleus
CC {ECO:0000250|UniProtKB:O95757}. Note=May translocate to the nucleus
CC after heat shock. {ECO:0000250|UniProtKB:O95757}.
CC -!- SIMILARITY: Belongs to the heat shock protein 70 family. {ECO:0000255}.
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DR AlphaFoldDB; P86265; -.
DR eggNOG; KOG0103; Eukaryota.
DR Proteomes; UP000189706; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0140662; F:ATP-dependent protein folding chaperone; IEA:InterPro.
DR InterPro; IPR043129; ATPase_NBD.
DR InterPro; IPR018181; Heat_shock_70_CS.
DR InterPro; IPR013126; Hsp_70_fam.
DR Pfam; PF00012; HSP70; 2.
DR SUPFAM; SSF53067; SSF53067; 2.
DR PROSITE; PS01036; HSP70_3; 1.
PE 1: Evidence at protein level;
KW ATP-binding; Chaperone; Cytoplasm; Nucleotide-binding; Nucleus;
KW Phosphoprotein; Reference proteome; Stress response.
FT CHAIN <1..>211
FT /note="Heat shock 70 kDa protein 4L"
FT /id="PRO_0000394416"
FT MOD_RES 161
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:O95757"
FT NON_CONS 43..44
FT /evidence="ECO:0000305"
FT NON_CONS 59..60
FT /evidence="ECO:0000305"
FT NON_CONS 79..80
FT /evidence="ECO:0000305"
FT NON_CONS 94..95
FT /evidence="ECO:0000305"
FT NON_CONS 152..153
FT /evidence="ECO:0000305"
FT NON_CONS 160..161
FT /evidence="ECO:0000305"
FT NON_CONS 172..173
FT /evidence="ECO:0000305"
FT NON_CONS 185..186
FT /evidence="ECO:0000305"
FT NON_CONS 194..195
FT /evidence="ECO:0000305"
FT NON_TER 1
FT NON_TER 211
SQ SEQUENCE 211 AA; 23670 MW; E61393D6FD82A4FC CRC64;
SVVGIDLGFL NCYIAVARSG GIETIANEYS DRCTPACISL GSRSQIVTNV RNTIHGFKKI
RLPYELQKMP NGSTGVKVRL KVLATTFDPY LGGRVEPPLK SVMDQANLQR EDINSIEIVG
GATRIPAVKE QVTRFFLKDI STTLNADEAV ARNHPAPFSK SIDLPIQSSL YRNAVEEYVY
DFRDKFITPE DMNKYGQPIQ MKYVEHEERP K