ID   HS7C4_DICDI             Reviewed;         569 AA.
AC   Q54BD8;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   03-AUG-2022, entry version 97.
DE   RecName: Full=Heat shock cognate 70 kDa protein 4;
DE            Short=HSC70-4;
GN   ORFNames=DDB_G0293678;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- FUNCTION: May function in protein folding and assembly, and disassembly
CC       of protein complexes. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the heat shock protein 70 family. {ECO:0000305}.
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DR   EMBL; AAFI02000218; EAL60651.1; -; Genomic_DNA.
DR   RefSeq; XP_629091.1; XM_629089.1.
DR   AlphaFoldDB; Q54BD8; -.
DR   SMR; Q54BD8; -.
DR   STRING; 44689.DDB0192088; -.
DR   PaxDb; Q54BD8; -.
DR   EnsemblProtists; EAL60651; EAL60651; DDB_G0293678.
DR   GeneID; 8629384; -.
DR   KEGG; ddi:DDB_G0293678; -.
DR   dictyBase; DDB_G0293678; -.
DR   eggNOG; KOG0101; Eukaryota.
DR   HOGENOM; CLU_005965_0_1_1; -.
DR   InParanoid; Q54BD8; -.
DR   PhylomeDB; Q54BD8; -.
DR   Reactome; R-DDI-3371497; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand.
DR   PRO; PR:Q54BD8; -.
DR   Proteomes; UP000002195; Chromosome 6.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005524; F:ATP binding; IBA:GO_Central.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IBA:GO_Central.
DR   GO; GO:0140662; F:ATP-dependent protein folding chaperone; IEA:InterPro.
DR   GO; GO:0031072; F:heat shock protein binding; IBA:GO_Central.
DR   GO; GO:0051787; F:misfolded protein binding; IBA:GO_Central.
DR   GO; GO:0044183; F:protein folding chaperone; IBA:GO_Central.
DR   GO; GO:0051082; F:unfolded protein binding; IBA:GO_Central.
DR   GO; GO:0034620; P:cellular response to unfolded protein; IBA:GO_Central.
DR   GO; GO:0051085; P:chaperone cofactor-dependent protein refolding; IBA:GO_Central.
DR   GO; GO:0042026; P:protein refolding; IBA:GO_Central.
DR   Gene3D; 2.60.34.10; -; 1.
DR   InterPro; IPR043129; ATPase_NBD.
DR   InterPro; IPR018181; Heat_shock_70_CS.
DR   InterPro; IPR029047; HSP70_peptide-bd_sf.
DR   InterPro; IPR013126; Hsp_70_fam.
DR   PANTHER; PTHR19375; PTHR19375; 1.
DR   Pfam; PF00012; HSP70; 1.
DR   SUPFAM; SSF100920; SSF100920; 1.
DR   SUPFAM; SSF53067; SSF53067; 2.
DR   PROSITE; PS00297; HSP70_1; 1.
DR   PROSITE; PS00329; HSP70_2; 1.
DR   PROSITE; PS01036; HSP70_3; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Chaperone; Nucleotide-binding; Reference proteome.
FT   CHAIN           1..569
FT                   /note="Heat shock cognate 70 kDa protein 4"
FT                   /id="PRO_0000327973"
SQ   SEQUENCE   569 AA;  63808 MW;  A9DC9D4866FBB98E CRC64;
     MPSMGIDLGT TYSCVGVCNE KGRIEIIAND QGNRTTPSYV SFNNRECLIG DDAMNQVAMN
     PVNTIFDVKR LFGRKYSDSV VQSDMKLWPF KVIANKFDDK PLIQVDFKGE TKTFSPEEIS
     SMVLSKMKEI VEQHLGEPVT DAVITVPAYF NDRQRHATKY AGTISNLNVL RIINEPTATA
     IAYGLHRRGI DDMKVLIIDL GGGTFDVSLF NIEDGIYEIL LSGGDNHLGG ADFNNRLMNH
     FIDEFKLKHK KDITNNQRAI FRLRTACERA KRTLSISSLA SIEIDSLYDG IDFYSTITRT
     HFEKLCSDLF HSCIDHVETI LNKCKLDKSL VDEIVLAGGS TQIPKIQRMF KEYFNGKEFN
     NSINPDEVVA YGAAVQSGVI SGKGSNFPQL IFLNVTPLSM GIETVGGIMT NLVERNTHIP
     IKKTQTFSTQ YDNQTNVLIQ IYEGERTMTK DNNLIGTFEL NGIPPAPRGV TQIEVCFDVD
     IDGILTVSAE DKTTKKVQKI TISNINDHLS KVEIEKMIVD GEKFKQQDQQ QKKELIESNY
     KIYCGDENTL DFEITQKLLG SAQSTEMNE