ID   HS7C5_DICDI             Reviewed;         517 AA.
AC   Q54MR6;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   03-AUG-2022, entry version 89.
DE   RecName: Full=Heat shock 70-related protein 5;
GN   ORFNames=DDB_G0285709;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- FUNCTION: May function in protein folding and assembly, and disassembly
CC       of protein complexes. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the heat shock protein 70 family. {ECO:0000305}.
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DR   EMBL; AAFI02000079; EAL64692.1; -; Genomic_DNA.
DR   RefSeq; XP_638227.1; XM_633135.1.
DR   AlphaFoldDB; Q54MR6; -.
DR   SMR; Q54MR6; -.
DR   STRING; 44689.DDB0232925; -.
DR   PaxDb; Q54MR6; -.
DR   EnsemblProtists; EAL64692; EAL64692; DDB_G0285709.
DR   GeneID; 8625275; -.
DR   KEGG; ddi:DDB_G0285709; -.
DR   dictyBase; DDB_G0285709; -.
DR   eggNOG; KOG0101; Eukaryota.
DR   HOGENOM; CLU_005965_0_1_1; -.
DR   InParanoid; Q54MR6; -.
DR   OMA; EICPNQQ; -.
DR   PhylomeDB; Q54MR6; -.
DR   PRO; PR:Q54MR6; -.
DR   Proteomes; UP000002195; Chromosome 4.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0045335; C:phagocytic vesicle; HDA:dictyBase.
DR   GO; GO:0005524; F:ATP binding; IBA:GO_Central.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IBA:GO_Central.
DR   GO; GO:0140662; F:ATP-dependent protein folding chaperone; IEA:InterPro.
DR   GO; GO:0031072; F:heat shock protein binding; IBA:GO_Central.
DR   GO; GO:0051787; F:misfolded protein binding; IBA:GO_Central.
DR   GO; GO:0044183; F:protein folding chaperone; IBA:GO_Central.
DR   GO; GO:0051082; F:unfolded protein binding; IBA:GO_Central.
DR   GO; GO:0034620; P:cellular response to unfolded protein; IBA:GO_Central.
DR   GO; GO:0051085; P:chaperone cofactor-dependent protein refolding; IBA:GO_Central.
DR   GO; GO:0042026; P:protein refolding; IBA:GO_Central.
DR   Gene3D; 2.60.34.10; -; 1.
DR   InterPro; IPR043129; ATPase_NBD.
DR   InterPro; IPR029047; HSP70_peptide-bd_sf.
DR   InterPro; IPR013126; Hsp_70_fam.
DR   PANTHER; PTHR19375; PTHR19375; 1.
DR   Pfam; PF00012; HSP70; 1.
DR   SUPFAM; SSF100920; SSF100920; 1.
DR   SUPFAM; SSF53067; SSF53067; 2.
PE   3: Inferred from homology;
KW   ATP-binding; Chaperone; Nucleotide-binding; Reference proteome.
FT   CHAIN           1..517
FT                   /note="Heat shock 70-related protein 5"
FT                   /id="PRO_0000327974"
SQ   SEQUENCE   517 AA;  57367 MW;  89609D559109C980 CRC64;
     MANNNIMGID FGTHFACVGI FKNERIEICP NQQGNRTTPS VVSFVGDDKL VGDEAKAQMD
     RNPLNTIYDV KRLLGRKTTD ELFDHEVKKL SFKVTTYEDN NEKIEFQVNY KSNVVTLTPI
     EIATSILEQI KHTAETFIGG ESIKKAVISV PTDFTEKQRN DLKEAATAAG ITVVRMIHEH
     SAVALAYGYD QVKECSETTN ESKESNVMVF DLGGSGVSAS MIRVRSKLFE MIGNVSDHTV
     SGEHFDHVLV QHFTQEFNRK YRCDLTDNAR SKAKLKSACE KAKRNLSNMT QAALEIDSLY
     DGRDFFTNIT RARFEDMASG LIKGSINAVS QLLEKCNMTK EQVDKVLLVG GASRIPSVQN
     QLLNFFDNRQ DILERSMNQE EVVAHGTTIQ ATILAADKSN QSLTCNSSNI SMGAPFSAKF
     TPVTIGIQDS NGNLIPIIPS SSLIPCKRTF TLNTSSENQD NLNMAVYQGS APLAKDNQLV
     SRFIFKSSPN PIDVTFEIDN NNTLLIKSEQ ANYSIKF