ID   HS7EA_XENLA             Reviewed;         509 AA.
AC   A5D8N7;
DT   08-MAR-2011, integrated into UniProtKB/Swiss-Prot.
DT   12-JUN-2007, sequence version 1.
DT   03-AUG-2022, entry version 49.
DE   RecName: Full=Heat shock 70 kDa protein 14-A;
GN   Name=hspa14-a;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (MAY-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the ribosome-associated complex (RAC), a complex
CC       involved in folding or maintaining nascent polypeptides in a folding-
CC       competent state. {ECO:0000250}.
CC   -!- SUBUNIT: Component of ribosome-associated complex (RAC). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the heat shock protein 70 family. {ECO:0000305}.
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DR   EMBL; BC141751; AAI41752.1; -; mRNA.
DR   RefSeq; NP_001092168.1; NM_001098698.1.
DR   AlphaFoldDB; A5D8N7; -.
DR   SMR; A5D8N7; -.
DR   DNASU; 100049759; -.
DR   GeneID; 100049759; -.
DR   KEGG; xla:100049759; -.
DR   CTD; 100049759; -.
DR   Xenbase; XB-GENE-5932920; hspa14.L.
DR   OMA; YIKESKC; -.
DR   OrthoDB; 646813at2759; -.
DR   Proteomes; UP000186698; Chromosome 3L.
DR   Bgee; 100049759; Expressed in neurula embryo and 19 other tissues.
DR   GO; GO:0005829; C:cytosol; ISS:UniProtKB.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0140662; F:ATP-dependent protein folding chaperone; IEA:InterPro.
DR   CDD; cd10238; HSPA14-like_NBD; 1.
DR   Gene3D; 2.60.34.10; -; 1.
DR   InterPro; IPR043129; ATPase_NBD.
DR   InterPro; IPR029047; HSP70_peptide-bd_sf.
DR   InterPro; IPR013126; Hsp_70_fam.
DR   InterPro; IPR042049; HSPA14_NBD.
DR   PANTHER; PTHR19375; PTHR19375; 1.
DR   Pfam; PF00012; HSP70; 1.
DR   SUPFAM; SSF100920; SSF100920; 1.
DR   SUPFAM; SSF53067; SSF53067; 2.
PE   2: Evidence at transcript level;
KW   ATP-binding; Chaperone; Cytoplasm; Nucleotide-binding; Reference proteome.
FT   CHAIN           1..509
FT                   /note="Heat shock 70 kDa protein 14-A"
FT                   /id="PRO_0000405828"
SQ   SEQUENCE   509 AA;  54448 MW;  284EFE922815D611 CRC64;
     MAAIGVHLGC TCACVAVYKD GRADVVANDA GDRVTPAVVG FLEKEVIVGL AAKQSRVRNA
     ANTIVKVKQI LGRSYADPHA QKHISENKCI VVEKGGKPKY EIDTGEIQKL VSSEDVAKLI
     FSKMKETAQS ALGSDVNDVV ITVPFDFGES QKKALGEAAL AAGFNILRMI HEPSAALLAY
     GIGQESPTGK SNVLVYKLGG TSLSVTMIEV NSGIYRVLAT STYDGIGGVC FTEALAQHLA
     SEFQRTYKQD IRGNARAMMK LMNSADVAKH ALSTLGSANC FVDSLYDGID FDCSVSRARF
     ELICSSLFNQ CIDPIEKLLE QVGCKATDVN QVVLCGGSAR IPKLQLLIKD LFPEVEMLSS
     IPPDEVIPVG AAIQAGILLG KENLSTDLDT ITIECLASDI LVKETDESGN NKFTVLLPSG
     TPLPARRQHV LQAPGNISSV CLELYESVGK STVSEECKFA QIVLKDLQKK ASGVHDILTV
     LTMKRDGSLH ITCTDKDSGK SEMITVETS