ID   HSBP1_BOVIN             Reviewed;          76 AA.
AC   Q3ZC22;
DT   11-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT   27-SEP-2005, sequence version 1.
DT   03-AUG-2022, entry version 92.
DE   RecName: Full=Heat shock factor-binding protein 1;
GN   Name=HSBP1;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Crossbred X Angus; TISSUE=Ileum;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Negative regulator of the heat shock response. Negatively
CC       affects HSF1 DNA-binding activity. May have a role in the suppression
CC       of the activation of the stress response during the aging process (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Homohexamer. Associates with heptad repeats of HSF1 trimers
CC       and probably also HSF1 monomers, and with HSP70. Association with HSF1
CC       trimers and HSP70 coincides with attenuation of heat shock response and
CC       the conversion of HSF1 trimer to monomer (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the HSBP1 family. {ECO:0000305}.
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DR   EMBL; BC102970; AAI02971.1; -; mRNA.
DR   RefSeq; NP_001106787.1; NM_001113316.2.
DR   RefSeq; XP_005218458.1; XM_005218401.3.
DR   AlphaFoldDB; Q3ZC22; -.
DR   SMR; Q3ZC22; -.
DR   PaxDb; Q3ZC22; -.
DR   Ensembl; ENSBTAT00000077997; ENSBTAP00000059922; ENSBTAG00000053436.
DR   Ensembl; ENSBTAT00000079124; ENSBTAP00000068641; ENSBTAG00000053436.
DR   GeneID; 767979; -.
DR   KEGG; bta:767979; -.
DR   CTD; 3281; -.
DR   VEuPathDB; HostDB:ENSBTAG00000053436; -.
DR   eggNOG; KOG4117; Eukaryota.
DR   GeneTree; ENSGT00390000006293; -.
DR   HOGENOM; CLU_149552_2_0_1; -.
DR   InParanoid; Q3ZC22; -.
DR   OMA; VDPKNMQ; -.
DR   OrthoDB; 1576489at2759; -.
DR   TreeFam; TF314005; -.
DR   Proteomes; UP000009136; Chromosome 18.
DR   Bgee; ENSBTAG00000053436; Expressed in occipital lobe and 107 other tissues.
DR   GO; GO:1904115; C:axon cytoplasm; IEA:GOC.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR   GO; GO:0003714; F:transcription corepressor activity; IEA:InterPro.
DR   GO; GO:0019896; P:axonal transport of mitochondrion; IEA:Ensembl.
DR   GO; GO:0070370; P:cellular heat acclimation; IBA:GO_Central.
DR   InterPro; IPR009643; HS1-bd.
DR   PANTHER; PTHR19424; PTHR19424; 1.
DR   Pfam; PF06825; HSBP1; 1.
PE   3: Inferred from homology;
KW   Nucleus; Reference proteome.
FT   CHAIN           1..76
FT                   /note="Heat shock factor-binding protein 1"
FT                   /id="PRO_0000245859"
SQ   SEQUENCE   76 AA;  8530 MW;  9838423DC3B2D402 CRC64;
     MAETDPKTVQ DLTSVVQTLL QQMQDKFQTM SDQIIGRIDD MSSRIDDLEK NIADLMTQAG
     VEELDSENKI PATQKS