ID   HSBP1_PONAB             Reviewed;          76 AA.
AC   Q5RDI2;
DT   10-MAY-2005, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   03-AUG-2022, entry version 52.
DE   RecName: Full=Heat shock factor-binding protein 1;
GN   Name=HSBP1;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain cortex;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Negative regulator of the heat shock response. Negatively
CC       affects HSF1 DNA-binding activity. May have a role in the suppression
CC       of the activation of the stress response during the aging process (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Homohexamer. Associates with heptad repeats of HSF1 trimers
CC       and probably also HSF1 monomers, and with HSP70. Association with HSF1
CC       trimers and HSP70 coincides with attenuation of heat shock response and
CC       the conversion of HSF1 trimer to monomer (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the HSBP1 family. {ECO:0000305}.
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DR   EMBL; CR857927; CAH90175.1; -; mRNA.
DR   RefSeq; NP_001125059.1; NM_001131587.1.
DR   AlphaFoldDB; Q5RDI2; -.
DR   SMR; Q5RDI2; -.
DR   STRING; 9601.ENSPPYP00000008675; -.
DR   Ensembl; ENSPPYT00000042244; ENSPPYP00000041031; ENSPPYG00000041045.
DR   GeneID; 100171940; -.
DR   KEGG; pon:100171940; -.
DR   CTD; 3281; -.
DR   eggNOG; KOG4117; Eukaryota.
DR   GeneTree; ENSGT00390000006293; -.
DR   InParanoid; Q5RDI2; -.
DR   OrthoDB; 1576489at2759; -.
DR   Proteomes; UP000001595; Chromosome 16.
DR   GO; GO:1904115; C:axon cytoplasm; IEA:GOC.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR   GO; GO:0003714; F:transcription corepressor activity; IEA:InterPro.
DR   GO; GO:0019896; P:axonal transport of mitochondrion; IEA:Ensembl.
DR   InterPro; IPR009643; HS1-bd.
DR   PANTHER; PTHR19424; PTHR19424; 1.
DR   Pfam; PF06825; HSBP1; 1.
PE   3: Inferred from homology;
KW   Nucleus; Reference proteome.
FT   CHAIN           1..76
FT                   /note="Heat shock factor-binding protein 1"
FT                   /id="PRO_0000124807"
SQ   SEQUENCE   76 AA;  8514 MW;  9838537886B2D402 CRC64;
     MAETDPKTVQ DLTSVVQTLL QQMQDKFQTM SDQIIGRIDD MSSRIDDLEK NIADLMTQAG
     VEELEGENKI PATQKS