ID   HSBP1_RAT               Reviewed;          76 AA.
AC   Q8K3X8;
DT   10-MAY-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 1.
DT   03-AUG-2022, entry version 92.
DE   RecName: Full=Heat shock factor-binding protein 1;
GN   Name=Hsbp1;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Zhang H., Lin J., Li Y., Xu C.;
RT   "A novel gene found in C6 cell line.";
RL   Submitted (JUN-2002) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Pituitary;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Negative regulator of the heat shock response. Negatively
CC       affects HSF1 DNA-binding activity. May have a role in the suppression
CC       of the activation of the stress response during the aging process (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Homohexamer. Associates with heptad repeats of HSF1 trimers
CC       and probably also HSF1 monomers, and with HSP70. Association with HSF1
CC       trimers and HSP70 coincides with attenuation of heat shock response and
CC       the conversion of HSF1 trimer to monomer (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the HSBP1 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AF522937; AAM81322.1; -; mRNA.
DR   EMBL; BC058131; AAH58131.1; -; mRNA.
DR   RefSeq; NP_775142.1; NM_173119.2.
DR   AlphaFoldDB; Q8K3X8; -.
DR   SMR; Q8K3X8; -.
DR   STRING; 10116.ENSRNOP00000019443; -.
DR   iPTMnet; Q8K3X8; -.
DR   PhosphoSitePlus; Q8K3X8; -.
DR   jPOST; Q8K3X8; -.
DR   PaxDb; Q8K3X8; -.
DR   PRIDE; Q8K3X8; -.
DR   GeneID; 286899; -.
DR   KEGG; rno:286899; -.
DR   UCSC; RGD:628632; rat.
DR   CTD; 3281; -.
DR   RGD; 628632; Hsbp1.
DR   VEuPathDB; HostDB:ENSRNOG00000014415; -.
DR   eggNOG; KOG4117; Eukaryota.
DR   HOGENOM; CLU_149552_2_0_1; -.
DR   InParanoid; Q8K3X8; -.
DR   OMA; VDPKNMQ; -.
DR   OrthoDB; 1576489at2759; -.
DR   PhylomeDB; Q8K3X8; -.
DR   TreeFam; TF314005; -.
DR   Reactome; R-RNO-3371568; Attenuation phase.
DR   Reactome; R-RNO-3371571; HSF1-dependent transactivation.
DR   PRO; PR:Q8K3X8; -.
DR   Proteomes; UP000002494; Chromosome 19.
DR   Bgee; ENSRNOG00000014415; Expressed in lung and 20 other tissues.
DR   Genevisible; Q8K3X8; RN.
DR   GO; GO:1904115; C:axon cytoplasm; IEA:GOC.
DR   GO; GO:0005856; C:cytoskeleton; IDA:RGD.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0042802; F:identical protein binding; ISO:RGD.
DR   GO; GO:0003714; F:transcription corepressor activity; IEA:InterPro.
DR   GO; GO:0019896; P:axonal transport of mitochondrion; ISO:RGD.
DR   GO; GO:0070370; P:cellular heat acclimation; IBA:GO_Central.
DR   GO; GO:0035987; P:endodermal cell differentiation; ISO:RGD.
DR   GO; GO:0006936; P:muscle contraction; IDA:RGD.
DR   InterPro; IPR009643; HS1-bd.
DR   PANTHER; PTHR19424; PTHR19424; 1.
DR   Pfam; PF06825; HSBP1; 1.
PE   3: Inferred from homology;
KW   Nucleus; Reference proteome.
FT   CHAIN           1..76
FT                   /note="Heat shock factor-binding protein 1"
FT                   /id="PRO_0000124808"
SQ   SEQUENCE   76 AA;  8585 MW;  3E86DF5C88E2CB56 CRC64;
     MAETDPKTMQ DITLVVETLL QQMQDKFQIM SDQIIGRIDD MSSRIDDLEK NIADLMTQAG
     VEELDAENKI PTAQKS