HSBPL_HUMAN
ID HSBPL_HUMAN Reviewed; 74 AA.
AC C9JCN9; B2RXG9;
DT 15-JUN-2010, integrated into UniProtKB/Swiss-Prot.
DT 15-JUN-2010, sequence version 2.
DT 03-AUG-2022, entry version 78.
DE RecName: Full=Heat shock factor-binding protein 1-like protein 1;
GN Name=HSBP1L1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16177791; DOI=10.1038/nature03983;
RA Nusbaum C., Zody M.C., Borowsky M.L., Kamal M., Kodira C.D., Taylor T.D.,
RA Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X.,
RA Abouelleil A., Allen N.R., Anderson S., Bloom T., Bugalter B., Butler J.,
RA Cook A., DeCaprio D., Engels R., Garber M., Gnirke A., Hafez N., Hall J.L.,
RA Norman C.H., Itoh T., Jaffe D.B., Kuroki Y., Lehoczky J., Lui A.,
RA Macdonald P., Mauceli E., Mikkelsen T.S., Naylor J.W., Nicol R., Nguyen C.,
RA Noguchi H., O'Leary S.B., Piqani B., Smith C.L., Talamas J.A., Topham K.,
RA Totoki Y., Toyoda A., Wain H.M., Young S.K., Zeng Q., Zimmer A.R.,
RA Fujiyama A., Hattori M., Birren B.W., Sakaki Y., Lander E.S.;
RT "DNA sequence and analysis of human chromosome 18.";
RL Nature 437:551-555(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC C9JCN9; Q6RW13-2: AGTRAP; NbExp=3; IntAct=EBI-2685549, EBI-11522760;
CC C9JCN9; P13196: ALAS1; NbExp=3; IntAct=EBI-2685549, EBI-3905054;
CC C9JCN9; Q8IZR5-2: CMTM4; NbExp=3; IntAct=EBI-2685549, EBI-17278014;
CC C9JCN9; Q9Y680: FKBP7; NbExp=3; IntAct=EBI-2685549, EBI-3918971;
CC C9JCN9; Q14696: MESD; NbExp=3; IntAct=EBI-2685549, EBI-6165891;
CC C9JCN9; Q8NI38: NFKBID; NbExp=3; IntAct=EBI-2685549, EBI-10271199;
CC C9JCN9; Q9BYU1: PBX4; NbExp=3; IntAct=EBI-2685549, EBI-10302990;
CC C9JCN9; Q04941: PLP2; NbExp=3; IntAct=EBI-2685549, EBI-608347;
CC C9JCN9; O43761: SYNGR3; NbExp=3; IntAct=EBI-2685549, EBI-11321949;
CC C9JCN9; Q9UBN6: TNFRSF10D; NbExp=3; IntAct=EBI-2685549, EBI-1044859;
CC -!- SIMILARITY: Belongs to the HSBP1 family. {ECO:0000305}.
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DR EMBL; AC090360; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC114341; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471117; EAW66638.1; -; Genomic_DNA.
DR EMBL; BC157848; AAI57849.1; -; mRNA.
DR CCDS; CCDS45886.1; -.
DR RefSeq; NP_001129652.1; NM_001136180.1.
DR AlphaFoldDB; C9JCN9; -.
DR SMR; C9JCN9; -.
DR BioGRID; 136630; 11.
DR IntAct; C9JCN9; 11.
DR STRING; 9606.ENSP00000414236; -.
DR iPTMnet; C9JCN9; -.
DR PhosphoSitePlus; C9JCN9; -.
DR BioMuta; HSBP1L1; -.
DR PaxDb; C9JCN9; -.
DR PeptideAtlas; C9JCN9; -.
DR PRIDE; C9JCN9; -.
DR TopDownProteomics; C9JCN9; -.
DR Antibodypedia; 62785; 10 antibodies from 6 providers.
DR DNASU; 440498; -.
DR Ensembl; ENST00000451882.3; ENSP00000414236.1; ENSG00000226742.4.
DR GeneID; 440498; -.
DR KEGG; hsa:440498; -.
DR MANE-Select; ENST00000451882.3; ENSP00000414236.1; NM_001136180.2; NP_001129652.1.
DR UCSC; uc002lno.5; human.
DR CTD; 440498; -.
DR GeneCards; HSBP1L1; -.
DR HGNC; HGNC:37243; HSBP1L1.
DR HPA; ENSG00000226742; Low tissue specificity.
DR neXtProt; NX_C9JCN9; -.
DR OpenTargets; ENSG00000226742; -.
DR PharmGKB; PA165429036; -.
DR VEuPathDB; HostDB:ENSG00000226742; -.
DR eggNOG; ENOG502SE6P; Eukaryota.
DR GeneTree; ENSGT00550000076117; -.
DR HOGENOM; CLU_149552_4_0_1; -.
DR InParanoid; C9JCN9; -.
DR OMA; YQLQENF; -.
DR OrthoDB; 1576489at2759; -.
DR PhylomeDB; C9JCN9; -.
DR PathwayCommons; C9JCN9; -.
DR SignaLink; C9JCN9; -.
DR BioGRID-ORCS; 440498; 13 hits in 995 CRISPR screens.
DR GenomeRNAi; 440498; -.
DR Pharos; C9JCN9; Tdark.
DR PRO; PR:C9JCN9; -.
DR Proteomes; UP000005640; Chromosome 18.
DR RNAct; C9JCN9; protein.
DR Bgee; ENSG00000226742; Expressed in lower esophagus mucosa and 138 other tissues.
DR ExpressionAtlas; C9JCN9; baseline and differential.
DR Genevisible; C9JCN9; HS.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0003714; F:transcription corepressor activity; IEA:InterPro.
DR GO; GO:0070370; P:cellular heat acclimation; IBA:GO_Central.
DR InterPro; IPR009643; HS1-bd.
DR PANTHER; PTHR19424; PTHR19424; 1.
DR Pfam; PF06825; HSBP1; 1.
PE 1: Evidence at protein level;
KW Coiled coil; Reference proteome.
FT CHAIN 1..74
FT /note="Heat shock factor-binding protein 1-like protein 1"
FT /id="PRO_0000394662"
FT COILED 12..65
FT /evidence="ECO:0000255"
FT CONFLICT 55
FT /note="K -> N (in Ref. 3; AAI57849)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 74 AA; 8384 MW; 92AF41A11C23FACB CRC64;
MDVRGPEAPG GRALRDAAEN LFQELQEHFQ ALTATLNLRM EEMGNRIEDL QKNVKDLMVQ
AGIENSIKEQ MLKT
