ID   3SX2_MICMP              Reviewed;          81 AA.
AC   A0A2P1BSS9;
DT   12-AUG-2020, integrated into UniProtKB/Swiss-Prot.
DT   23-MAY-2018, sequence version 1.
DT   25-MAY-2022, entry version 8.
DE   RecName: Full=Mipartoxin-2 {ECO:0000305};
DE   AltName: Full=Mipartoxin-II {ECO:0000303|PubMed:31557485};
DE   AltName: Full=Three-finger toxin-03 {ECO:0000303|PubMed:31557485};
DE            Short=3FTx-03 {ECO:0000303|PubMed:31557485};
DE   Flags: Precursor;
OS   Micrurus mipartitus (Red-tailed coral snake).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC   Serpentes; Colubroidea; Elapidae; Elapinae; Micrurus.
OX   NCBI_TaxID=430902 {ECO:0000312|EMBL:AVI57321.1};
RN   [1] {ECO:0000305}
RP   NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC   TISSUE=Venom gland {ECO:0000303|PubMed:31557485};
RX   PubMed=31557485; DOI=10.1016/j.toxicon.2019.09.017;
RA   Rey-Suarez P., Saldarriaga-Cordoba M., Torres U., Marin-Villa M.,
RA   Lomonte B., Nunez V.;
RT   "Novel three-finger toxins from Micrurus dumerilii and Micrurus mipartitus
RT   coral snake venoms: Phylogenetic relationships and characterization of
RT   Clarkitoxin-I-Mdum.";
RL   Toxicon 170:85-93(2019).
CC   -!- FUNCTION: Snake venom neurotoxin that blocks neuromuscular
CC       transmission, presenting a postsynaptic action through the nicotinic
CC       acetylcholine receptor (nAChR). Has no cytotoxic activity.
CC       {ECO:0000250|UniProtKB:B3EWF8}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:B3EWF8}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC       {ECO:0000269|PubMed:31557485}.
CC   -!- SIMILARITY: Belongs to the snake three-finger toxin family. Short-chain
CC       subfamily. {ECO:0000305}.
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DR   EMBL; KY635902; AVI57321.1; -; mRNA.
DR   AlphaFoldDB; A0A2P1BSS9; -.
DR   SMR; A0A2P1BSS9; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0030550; F:acetylcholine receptor inhibitor activity; IEA:UniProtKB-KW.
DR   GO; GO:0099106; F:ion channel regulator activity; IEA:UniProtKB-KW.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   Gene3D; 2.10.60.10; -; 1.
DR   InterPro; IPR045860; Snake_toxin-like_sf.
DR   SUPFAM; SSF57302; SSF57302; 1.
PE   2: Evidence at transcript level;
KW   Acetylcholine receptor inhibiting toxin; Disulfide bond;
KW   Ion channel impairing toxin; Neurotoxin; Postsynaptic neurotoxin; Secreted;
KW   Signal; Toxin.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000255"
FT   CHAIN           22..81
FT                   /note="Mipartoxin-2"
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_5015174314"
FT   DISULFID        24..42
FT                   /evidence="ECO:0000250|UniProtKB:P07526"
FT   DISULFID        35..61
FT                   /evidence="ECO:0000250|UniProtKB:P07526"
FT   DISULFID        65..73
FT                   /evidence="ECO:0000250|UniProtKB:P07526"
FT   DISULFID        74..79
FT                   /evidence="ECO:0000250|UniProtKB:P07526"
SQ   SEQUENCE   81 AA;  9177 MW;  14BB5E1FEBFA958B CRC64;
     MKTLLLTLVV VTIVCLDLGN SLICYVSREG QTQTCPEGMN LCEKYAVSYF HDGRYFFTYE
     CTSTCHRGDR NVCCSTDLCN K