ID   AP2E_XENLA              Reviewed;         434 AA.
AC   Q2T9K2;
DT   13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT   24-JAN-2006, sequence version 1.
DT   03-AUG-2022, entry version 58.
DE   RecName: Full=Transcription factor AP-2-epsilon;
DE            Short=AP-2-epsilon;
GN   Name=tfap2e {ECO:0000250|UniProtKB:Q6VUC0};
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1] {ECO:0000312|EMBL:AAI11479.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo {ECO:0000312|EMBL:AAI11479.1};
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (DEC-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Sequence-specific DNA-binding protein that interacts with
CC       inducible viral and cellular enhancer elements to regulate
CC       transcription of selected genes. AP-2 factors bind to the consensus
CC       sequence 5'-GCCNNNGGC-3' and activate genes involved in a large
CC       spectrum of important biological functions (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Binds DNA as a dimer. Can form homodimers or heterodimers with
CC       other AP-2 family members (By similarity).
CC       {ECO:0000250|UniProtKB:Q6VUP9}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q6VUP9}.
CC   -!- SIMILARITY: Belongs to the AP-2 family. {ECO:0000255}.
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DR   EMBL; BC111478; AAI11479.1; -; mRNA.
DR   RefSeq; NP_001089958.1; NM_001096489.1.
DR   AlphaFoldDB; Q2T9K2; -.
DR   DNASU; 735028; -.
DR   GeneID; 735028; -.
DR   KEGG; xla:735028; -.
DR   CTD; 735028; -.
DR   Xenbase; XB-GENE-876809; tfap2e.L.
DR   OMA; ACAWSEE; -.
DR   OrthoDB; 641707at2759; -.
DR   Proteomes; UP000186698; Chromosome 2L.
DR   Bgee; 735028; Expressed in camera-type eye and 4 other tissues.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   InterPro; IPR004979; TF_AP2.
DR   InterPro; IPR013854; TF_AP2_C.
DR   PANTHER; PTHR10812; PTHR10812; 1.
DR   Pfam; PF03299; TF_AP-2; 1.
DR   PRINTS; PR01748; AP2TNSCPFCT.
PE   2: Evidence at transcript level;
KW   Activator; DNA-binding; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..434
FT                   /note="Transcription factor AP-2-epsilon"
FT                   /id="PRO_0000309519"
FT   REGION          30..123
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          278..408
FT                   /note="H-S-H (helix-span-helix), dimerization"
FT                   /evidence="ECO:0000255"
FT   REGION          415..434
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           53..58
FT                   /note="PPxY motif"
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        45..63
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        82..98
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   434 AA;  47050 MW;  05026B260D662200 CRC64;
     MLVHAYSAMD RSEVLNGAAS GGRLSQLSSL NQGPYSSAPP LCHTPASDFQ PPYFPPPYPQ
     PPLSYSQSQE SGYPHLGDPY SSINSIHHQH QQPSWHTPRS RPEEAGLLSQ THRGLSLDPR
     RDYGGMSRLI PGLTDGGHSL ADSSLSIHAL SHHSLEDMQL LDESGISILD QSVIKKVPIS
     SKNNSSMMSA LSMNKESLIG GVSNPNEVFC SVPGRLSLLS STSKYKVTVG EVQRRLSPPE
     CLNASLLGGV LRRAKSKNGG RCLRERLEKI GLNLPAGRRK AANVTLLTSL VEGEAVHLAR
     DFGYVCETEF PAKAAAEYLC RQHSDPTELH ARKNMLLATK QICKEFADLL AQDRSPLGNS
     RPSLILEPGV QSCLTHFSLI THGFGGPAIC AALTAFQNYL LESLKGMDKI FMSSTGNGHS
     AAESKSEKDI KHRK