ID   HSCA_HAEIN              Reviewed;         619 AA.
AC   P44669;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   03-AUG-2022, entry version 122.
DE   RecName: Full=Chaperone protein HscA homolog;
GN   Name=hscA; OrderedLocusNames=HI_0373;
OS   Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC   Pasteurellaceae; Haemophilus.
OX   NCBI_TaxID=71421;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
RX   PubMed=7542800; DOI=10.1126/science.7542800;
RA   Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F.,
RA   Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M.,
RA   McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D.,
RA   Scott J.D., Shirley R., Liu L.-I., Glodek A., Kelley J.M., Weidman J.F.,
RA   Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R.,
RA   Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D.,
RA   Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A.,
RA   Small K.V., Fraser C.M., Smith H.O., Venter J.C.;
RT   "Whole-genome random sequencing and assembly of Haemophilus influenzae
RT   Rd.";
RL   Science 269:496-512(1995).
CC   -!- FUNCTION: Chaperone involved in the maturation of iron-sulfur cluster-
CC       containing proteins. Has a low intrinsic ATPase activity which is
CC       markedly stimulated by HscB (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the heat shock protein 70 family. {ECO:0000305}.
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DR   EMBL; L42023; AAC22031.1; -; Genomic_DNA.
DR   PIR; B64064; B64064.
DR   RefSeq; NP_438534.1; NC_000907.1.
DR   RefSeq; WP_005693792.1; NC_000907.1.
DR   AlphaFoldDB; P44669; -.
DR   SMR; P44669; -.
DR   STRING; 71421.HI_0373; -.
DR   TCDB; 9.A.41.1.1; the capsular polysaccharide exporter (cps-e) family.
DR   PRIDE; P44669; -.
DR   EnsemblBacteria; AAC22031; AAC22031; HI_0373.
DR   KEGG; hin:HI_0373; -.
DR   PATRIC; fig|71421.8.peg.391; -.
DR   eggNOG; COG0443; Bacteria.
DR   HOGENOM; CLU_005965_2_1_6; -.
DR   OMA; PDPHQRR; -.
DR   PhylomeDB; P44669; -.
DR   BioCyc; HINF71421:G1GJ1-386-MON; -.
DR   Proteomes; UP000000579; Chromosome.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0140662; F:ATP-dependent protein folding chaperone; IEA:InterPro.
DR   GO; GO:0051082; F:unfolded protein binding; IEA:InterPro.
DR   GO; GO:0016226; P:iron-sulfur cluster assembly; IEA:InterPro.
DR   CDD; cd10236; HscA_like_NBD; 1.
DR   Gene3D; 1.20.1270.10; -; 1.
DR   Gene3D; 2.60.34.10; -; 1.
DR   HAMAP; MF_00679; HscA; 1.
DR   InterPro; IPR043129; ATPase_NBD.
DR   InterPro; IPR018181; Heat_shock_70_CS.
DR   InterPro; IPR042039; HscA_NBD.
DR   InterPro; IPR029048; HSP70_C_sf.
DR   InterPro; IPR029047; HSP70_peptide-bd_sf.
DR   InterPro; IPR013126; Hsp_70_fam.
DR   InterPro; IPR010236; ISC_FeS_clus_asmbl_HscA.
DR   PANTHER; PTHR19375; PTHR19375; 1.
DR   Pfam; PF00012; HSP70; 1.
DR   SUPFAM; SSF100920; SSF100920; 1.
DR   SUPFAM; SSF100934; SSF100934; 1.
DR   SUPFAM; SSF53067; SSF53067; 2.
DR   TIGRFAMs; TIGR01991; HscA; 1.
DR   PROSITE; PS00297; HSP70_1; 1.
DR   PROSITE; PS00329; HSP70_2; 1.
DR   PROSITE; PS01036; HSP70_3; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Chaperone; Nucleotide-binding; Reference proteome.
FT   CHAIN           1..619
FT                   /note="Chaperone protein HscA homolog"
FT                   /id="PRO_0000078630"
SQ   SEQUENCE   619 AA;  66917 MW;  A9047BAC5F804C2E CRC64;
     MALLQIAEPG QAAAPHQHRL AVGIDLGTTN SLVASVRSGQ SVILNDEQER SLVPSVVHYG
     VEEKKVGLEA FEQASLDPKN TVISVKRLIG RSLSDVQSRY SSLPYEFVAS ENGLPLIITA
     QGAKSPIEVS SDILSRLNHI AEQRLGGELS GVVITVPAYF DDAQRQSTKD AARLAGLNVL
     RLLNEPTAAA LAYGLDSGQE GIIAVYDLGG GTFDISILRL SKGIFEVLAT GGDTALGGDD
     FDHLIADWVI EQTKLKPQTA NQQRELITLA NQAKITLTNE KSAVISWQDF SVEISREQFN
     ELIYPLVKRS LLTCRRALKD ANVESEEVQA VVMVGGSTRV PYVREQVGEF FGKTPLTSID
     PDKVVALGAA IQADILVGNK TDSDMLLLDV VPLSLGIETM GGLVEKIIPR NTTIPVARAQ
     EFTTFKDGQT AMTVHVLQGE RELVDDCRSL GRFTLRGIPP MAAGAAHIRV TYQVDADGLL
     SVTAMEKSTK VQASIQIKPS YGLTDEEVTA MIKSSFDNAQ EDLQARELAE QRVEADRVIE
     SVIVALQADG AELLSTDEFH HIETVLKQLM DVKQGSDRDA IAQGIKALDT ATQEFAARRM
     NASINKALTG KNLSDIENP