AP2L4_ARATH
ID AP2L4_ARATH Reviewed; 428 AA.
AC Q8GWK2; O22949; Q8LA00;
DT 12-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT 12-JUN-2007, sequence version 2.
DT 03-AUG-2022, entry version 117.
DE RecName: Full=AP2-like ethylene-responsive transcription factor At2g41710;
GN OrderedLocusNames=At2g41710; ORFNames=T11A7.19;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617197; DOI=10.1038/45471;
RA Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S.,
RA Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL Nature 402:761-768(1999).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=cv. Columbia;
RX PubMed=11910074; DOI=10.1126/science.1071006;
RA Seki M., Narusaka M., Kamiya A., Ishida J., Satou M., Sakurai T.,
RA Nakajima M., Enju A., Akiyama K., Oono Y., Muramatsu M., Hayashizaki Y.,
RA Kawai J., Carninci P., Itoh M., Ishii Y., Arakawa T., Shibata K.,
RA Shinagawa A., Shinozaki K.;
RT "Functional annotation of a full-length Arabidopsis cDNA collection.";
RL Science 296:141-145(2002).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=cv. Columbia;
RA Shinn P., Chen H., Kim C.J., Quinitio C., Ecker J.R.;
RT "Arabidopsis ORF clones.";
RL Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RA Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B.,
RA Feldmann K.A.;
RT "Full-length cDNA from Arabidopsis thaliana.";
RL Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=16407444; DOI=10.1104/pp.105.073783;
RA Nakano T., Suzuki K., Fujimura T., Shinshi H.;
RT "Genome-wide analysis of the ERF gene family in Arabidopsis and rice.";
RL Plant Physiol. 140:411-432(2006).
CC -!- FUNCTION: Probably acts as a transcriptional activator. Binds to the
CC GCC-box pathogenesis-related promoter element. May be involved in the
CC regulation of gene expression by stress factors and by components of
CC stress signal transduction pathways (By similarity). {ECO:0000250}.
CC -!- INTERACTION:
CC Q8GWK2; Q8GWR1: AAAS; NbExp=3; IntAct=EBI-25521547, EBI-4425567;
CC Q8GWK2; O64644: At2g45640; NbExp=3; IntAct=EBI-25521547, EBI-965964;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8GWK2-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8GWK2-2; Sequence=VSP_026151;
CC -!- MISCELLANEOUS: [Isoform 2]: May be due to a competing acceptor splice
CC site. {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the AP2/ERF transcription factor family. AP2
CC subfamily. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAC02777.2; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AC002339; AAC02777.2; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002685; AEC10021.1; -; Genomic_DNA.
DR EMBL; CP002685; AEC10022.1; -; Genomic_DNA.
DR EMBL; AK118789; BAC43380.1; -; mRNA.
DR EMBL; BT025985; ABG25074.1; -; mRNA.
DR EMBL; AY088118; AAM65663.1; -; mRNA.
DR PIR; B84845; B84845.
DR RefSeq; NP_565957.1; NM_129735.3. [Q8GWK2-2]
DR RefSeq; NP_850355.1; NM_180024.2. [Q8GWK2-1]
DR AlphaFoldDB; Q8GWK2; -.
DR SMR; Q8GWK2; -.
DR BioGRID; 4107; 2.
DR IntAct; Q8GWK2; 2.
DR STRING; 3702.AT2G41710.3; -.
DR PRIDE; Q8GWK2; -.
DR ProteomicsDB; 244960; -. [Q8GWK2-1]
DR EnsemblPlants; AT2G41710.1; AT2G41710.1; AT2G41710. [Q8GWK2-2]
DR EnsemblPlants; AT2G41710.2; AT2G41710.2; AT2G41710. [Q8GWK2-1]
DR GeneID; 818770; -.
DR Gramene; AT2G41710.1; AT2G41710.1; AT2G41710. [Q8GWK2-2]
DR Gramene; AT2G41710.2; AT2G41710.2; AT2G41710. [Q8GWK2-1]
DR KEGG; ath:AT2G41710; -.
DR Araport; AT2G41710; -.
DR eggNOG; ENOG502QR8V; Eukaryota.
DR HOGENOM; CLU_041859_0_0_1; -.
DR InParanoid; Q8GWK2; -.
DR OMA; KWWGPNK; -.
DR PhylomeDB; Q8GWK2; -.
DR PRO; PR:Q8GWK2; -.
DR Proteomes; UP000006548; Chromosome 2.
DR ExpressionAtlas; Q8GWK2; baseline and differential.
DR Genevisible; Q8GWK2; AT.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0009873; P:ethylene-activated signaling pathway; IEA:UniProtKB-KW.
DR Gene3D; 3.30.730.10; -; 1.
DR InterPro; IPR001471; AP2/ERF_dom.
DR InterPro; IPR036955; AP2/ERF_dom_sf.
DR InterPro; IPR016177; DNA-bd_dom_sf.
DR Pfam; PF00847; AP2; 1.
DR PRINTS; PR00367; ETHRSPELEMNT.
DR SMART; SM00380; AP2; 1.
DR SUPFAM; SSF54171; SSF54171; 1.
DR PROSITE; PS51032; AP2_ERF; 1.
PE 1: Evidence at protein level;
KW Activator; Alternative splicing; DNA-binding; Ethylene signaling pathway;
KW Nucleus; Reference proteome; Transcription; Transcription regulation.
FT CHAIN 1..428
FT /note="AP2-like ethylene-responsive transcription factor
FT At2g41710"
FT /id="PRO_0000290364"
FT DNA_BIND 70..136
FT /note="AP2/ERF"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00366"
FT REGION 1..28
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 162..166
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|Ref.4, ECO:0000303|Ref.5"
FT /id="VSP_026151"
FT CONFLICT 242
FT /note="P -> S (in Ref. 3; BAC43380)"
FT /evidence="ECO:0000305"
FT CONFLICT 283
FT /note="C -> R (in Ref. 5; AAM65663)"
FT /evidence="ECO:0000305"
FT CONFLICT 342
FT /note="N -> Y (in Ref. 5; AAM65663)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 428 AA; 47094 MW; 0CFC7902C3F7276D CRC64;
MASVSSSDQG PKTEAGCSGG GGGESSETVA ASDQMLLYRG FKKAKKERGC TAKERISKMP
PCTAGKRSSI YRGVTRHRWT GRYEAHLWDK STWNQNQNKK GKQVYLGAYD DEEAAARAYD
LAALKYWGPG TLINFPVTDY TRDLEEMQNL SREEYLASLR RYPFGRKSSG FSRGIAKYRG
LQSRWDASAS RMPGPEYFSN IHYGAGDDRG TEGDFLGSFC LERKIDLTGY IKWWGANKNR
QPESSSKASE DANVEDAGTE LKTLEHTSHA TEPYKAPNLG VLCGTQRKEK EISSPSSSSA
LSILSQSPAF KSLEEKVLKI QESCNNENDE NANRNIINME KNNGKAIEKP VVSHGVALGG
AAALSLQKSM YPLTSLLTAP LLTNYNTLDP LADPILWTPF LPSGSSLTSE VTKTETSCST
YSYLPQEK
