ID   HSCA_PSEAE              Reviewed;         619 AA.
AC   Q51382;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   08-DEC-2000, sequence version 2.
DT   03-AUG-2022, entry version 123.
DE   RecName: Full=Chaperone protein HscA homolog;
GN   Name=hscA; OrderedLocusNames=PA3810;
OS   Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM
OS   14847 / LMG 12228 / 1C / PRS 101 / PAO1).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC   Pseudomonadaceae; Pseudomonas.
OX   NCBI_TaxID=208964;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C /
RC   PRS 101 / PAO1;
RX   PubMed=10984043; DOI=10.1038/35023079;
RA   Stover C.K., Pham X.-Q.T., Erwin A.L., Mizoguchi S.D., Warrener P.,
RA   Hickey M.J., Brinkman F.S.L., Hufnagle W.O., Kowalik D.J., Lagrou M.,
RA   Garber R.L., Goltry L., Tolentino E., Westbrock-Wadman S., Yuan Y.,
RA   Brody L.L., Coulter S.N., Folger K.R., Kas A., Larbig K., Lim R.M.,
RA   Smith K.A., Spencer D.H., Wong G.K.-S., Wu Z., Paulsen I.T., Reizer J.,
RA   Saier M.H. Jr., Hancock R.E.W., Lory S., Olson M.V.;
RT   "Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic
RT   pathogen.";
RL   Nature 406:959-964(2000).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 439-619.
RC   STRAIN=8822;
RX   PubMed=8809750; DOI=10.1111/j.1365-2958.1996.tb02538.x;
RA   Sundin G.W., Shankar S., Chugani S.A., Chopade B., Kavanaugh-Black A.,
RA   Chakrabarty A.M.;
RT   "Nucleoside diphosphate kinase from Pseudomonas aeruginosa:
RT   characterization of the gene and its role in cellular growth and
RT   exopolysaccharide alginate synthesis.";
RL   Mol. Microbiol. 20:965-979(1996).
CC   -!- FUNCTION: Chaperone involved in the maturation of iron-sulfur cluster-
CC       containing proteins. Has a low intrinsic ATPase activity which is
CC       markedly stimulated by HscB (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the heat shock protein 70 family. {ECO:0000305}.
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DR   EMBL; AE004091; AAG07197.1; -; Genomic_DNA.
DR   EMBL; U41267; AAC44151.1; -; Genomic_DNA.
DR   PIR; C83168; C83168.
DR   PIR; S77590; S77590.
DR   RefSeq; NP_252499.1; NC_002516.2.
DR   RefSeq; WP_003100622.1; NZ_QZGE01000001.1.
DR   AlphaFoldDB; Q51382; -.
DR   SMR; Q51382; -.
DR   STRING; 287.DR97_4059; -.
DR   PaxDb; Q51382; -.
DR   PRIDE; Q51382; -.
DR   EnsemblBacteria; AAG07197; AAG07197; PA3810.
DR   GeneID; 879936; -.
DR   KEGG; pae:PA3810; -.
DR   PATRIC; fig|208964.12.peg.3989; -.
DR   PseudoCAP; PA3810; -.
DR   HOGENOM; CLU_005965_2_1_6; -.
DR   InParanoid; Q51382; -.
DR   OMA; PDPHQRR; -.
DR   PhylomeDB; Q51382; -.
DR   BioCyc; PAER208964:G1FZ6-3881-MON; -.
DR   Proteomes; UP000002438; Chromosome.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0140662; F:ATP-dependent protein folding chaperone; IEA:InterPro.
DR   GO; GO:0051082; F:unfolded protein binding; IEA:InterPro.
DR   GO; GO:0016226; P:iron-sulfur cluster assembly; IEA:InterPro.
DR   CDD; cd10236; HscA_like_NBD; 1.
DR   Gene3D; 1.20.1270.10; -; 1.
DR   Gene3D; 2.60.34.10; -; 1.
DR   HAMAP; MF_00679; HscA; 1.
DR   InterPro; IPR043129; ATPase_NBD.
DR   InterPro; IPR018181; Heat_shock_70_CS.
DR   InterPro; IPR042039; HscA_NBD.
DR   InterPro; IPR029048; HSP70_C_sf.
DR   InterPro; IPR029047; HSP70_peptide-bd_sf.
DR   InterPro; IPR013126; Hsp_70_fam.
DR   InterPro; IPR010236; ISC_FeS_clus_asmbl_HscA.
DR   PANTHER; PTHR19375; PTHR19375; 1.
DR   Pfam; PF00012; HSP70; 1.
DR   SUPFAM; SSF100920; SSF100920; 1.
DR   SUPFAM; SSF100934; SSF100934; 1.
DR   SUPFAM; SSF53067; SSF53067; 2.
DR   TIGRFAMs; TIGR01991; HscA; 1.
DR   PROSITE; PS00297; HSP70_1; 1.
DR   PROSITE; PS00329; HSP70_2; 1.
DR   PROSITE; PS01036; HSP70_3; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Chaperone; Nucleotide-binding; Reference proteome.
FT   CHAIN           1..619
FT                   /note="Chaperone protein HscA homolog"
FT                   /id="PRO_0000078639"
FT   CONFLICT        439
FT                   /note="Q -> A (in Ref. 2; AAC44151)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   619 AA;  66447 MW;  16064591183B89B2 CRC64;
     MALLQIAEPG QSPKPHERRL AVGIDLGTTN SLVAAVRSGV AEPLPDAQGR LILPSAVRYH
     AERAEVGESA RAAAAEDPFN TVISVKRLMG RGLEDVKQLG EQLPYRFRQG ESHMPFIETV
     QGLKSPVEVS ADILRELRQR AETTLGGELV GAVITVPAYF DDAQRQATKD AARLAGLNVL
     RLLNEPTAAA VAYGLDKGAE GLVAIYDLGG GTFDISILRL TRGVFEVLAT GGDTALGGDD
     FDHAIAGWVI EQAGLSADLD PGSQRQLLQI ACAAKERLTD EASVRVAYGD WSGELSRATL
     DELIEPFVAR SLKSCRRAVR DSGVDLEEIR SVVMVGGSTR VPRVRTAVGE LFGCEPLTDI
     DPDQVVAIGA AIQADALAGN KRGEELLLLD VIPLSLGLET MGGLMEKVIP RNTTIPVARA
     QEFTTYKDGQ TAMMIHVLQG ERELVKDCRS LARFELRGIP PMVAGAAKIR VTFQVDADGL
     LGVSARELSS GVEASIQVKP SYGLTDGEIA RMLKDSFDYA GDDKAARALR EQQVEAQRLL
     EAVQSALDVD GERLLDEEER LAIAAQMDTL RELAGGSDTA AIENQIKRLS QVTDAFAARR
     MDATVKAALS GRRLNEIEE