HSCA_YERPE
ID HSCA_YERPE Reviewed; 650 AA.
AC Q8ZCS5; Q0WD12; Q8D0Z5;
DT 19-JUL-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2002, sequence version 1.
DT 03-AUG-2022, entry version 123.
DE RecName: Full=Chaperone protein HscA;
DE AltName: Full=Hsc66;
GN Name=hscA; OrderedLocusNames=YPO2892, y1339, YP_2563;
OS Yersinia pestis.
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Yersiniaceae; Yersinia.
OX NCBI_TaxID=632;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CO-92 / Biovar Orientalis;
RX PubMed=11586360; DOI=10.1038/35097083;
RA Parkhill J., Wren B.W., Thomson N.R., Titball R.W., Holden M.T.G.,
RA Prentice M.B., Sebaihia M., James K.D., Churcher C.M., Mungall K.L.,
RA Baker S., Basham D., Bentley S.D., Brooks K., Cerdeno-Tarraga A.-M.,
RA Chillingworth T., Cronin A., Davies R.M., Davis P., Dougan G., Feltwell T.,
RA Hamlin N., Holroyd S., Jagels K., Karlyshev A.V., Leather S., Moule S.,
RA Oyston P.C.F., Quail M.A., Rutherford K.M., Simmonds M., Skelton J.,
RA Stevens K., Whitehead S., Barrell B.G.;
RT "Genome sequence of Yersinia pestis, the causative agent of plague.";
RL Nature 413:523-527(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KIM10+ / Biovar Mediaevalis;
RX PubMed=12142430; DOI=10.1128/jb.184.16.4601-4611.2002;
RA Deng W., Burland V., Plunkett G. III, Boutin A., Mayhew G.F., Liss P.,
RA Perna N.T., Rose D.J., Mau B., Zhou S., Schwartz D.C., Fetherston J.D.,
RA Lindler L.E., Brubaker R.R., Plano G.V., Straley S.C., McDonough K.A.,
RA Nilles M.L., Matson J.S., Blattner F.R., Perry R.D.;
RT "Genome sequence of Yersinia pestis KIM.";
RL J. Bacteriol. 184:4601-4611(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=91001 / Biovar Mediaevalis;
RX PubMed=15368893; DOI=10.1093/dnares/11.3.179;
RA Song Y., Tong Z., Wang J., Wang L., Guo Z., Han Y., Zhang J., Pei D.,
RA Zhou D., Qin H., Pang X., Han Y., Zhai J., Li M., Cui B., Qi Z., Jin L.,
RA Dai R., Chen F., Li S., Ye C., Du Z., Lin W., Wang J., Yu J., Yang H.,
RA Wang J., Huang P., Yang R.;
RT "Complete genome sequence of Yersinia pestis strain 91001, an isolate
RT avirulent to humans.";
RL DNA Res. 11:179-197(2004).
CC -!- FUNCTION: Chaperone involved in the maturation of iron-sulfur cluster-
CC containing proteins. Has a low intrinsic ATPase activity which is
CC markedly stimulated by HscB. Involved in the maturation of IscU (By
CC similarity). {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the heat shock protein 70 family. {ECO:0000305}.
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DR EMBL; AL590842; CAL21503.1; -; Genomic_DNA.
DR EMBL; AE009952; AAM84912.1; -; Genomic_DNA.
DR EMBL; AE017042; AAS62759.1; -; Genomic_DNA.
DR PIR; AD0352; AD0352.
DR RefSeq; WP_002209832.1; NZ_VIDZ01000064.1.
DR RefSeq; YP_002347826.1; NC_003143.1.
DR AlphaFoldDB; Q8ZCS5; -.
DR SMR; Q8ZCS5; -.
DR IntAct; Q8ZCS5; 2.
DR STRING; 214092.YPO2892; -.
DR PaxDb; Q8ZCS5; -.
DR DNASU; 1146286; -.
DR EnsemblBacteria; AAM84912; AAM84912; y1339.
DR EnsemblBacteria; AAS62759; AAS62759; YP_2563.
DR GeneID; 57975849; -.
DR KEGG; ype:YPO2892; -.
DR KEGG; ypk:y1339; -.
DR KEGG; ypm:YP_2563; -.
DR PATRIC; fig|214092.21.peg.3342; -.
DR eggNOG; COG0443; Bacteria.
DR HOGENOM; CLU_005965_2_1_6; -.
DR OMA; PDPHQRR; -.
DR Proteomes; UP000000815; Chromosome.
DR Proteomes; UP000001019; Chromosome.
DR Proteomes; UP000002490; Chromosome.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:UniProtKB-UniRule.
DR GO; GO:0140662; F:ATP-dependent protein folding chaperone; IEA:InterPro.
DR GO; GO:0051082; F:unfolded protein binding; IEA:InterPro.
DR GO; GO:0016226; P:iron-sulfur cluster assembly; IEA:InterPro.
DR CDD; cd10236; HscA_like_NBD; 1.
DR Gene3D; 1.20.1270.10; -; 1.
DR Gene3D; 2.60.34.10; -; 1.
DR HAMAP; MF_00679; HscA; 1.
DR InterPro; IPR043129; ATPase_NBD.
DR InterPro; IPR018181; Heat_shock_70_CS.
DR InterPro; IPR042039; HscA_NBD.
DR InterPro; IPR029048; HSP70_C_sf.
DR InterPro; IPR029047; HSP70_peptide-bd_sf.
DR InterPro; IPR013126; Hsp_70_fam.
DR InterPro; IPR010236; ISC_FeS_clus_asmbl_HscA.
DR PANTHER; PTHR19375; PTHR19375; 1.
DR Pfam; PF00012; HSP70; 1.
DR SUPFAM; SSF100920; SSF100920; 1.
DR SUPFAM; SSF100934; SSF100934; 1.
DR SUPFAM; SSF53067; SSF53067; 2.
DR TIGRFAMs; TIGR01991; HscA; 1.
DR PROSITE; PS00297; HSP70_1; 1.
DR PROSITE; PS00329; HSP70_2; 1.
DR PROSITE; PS01036; HSP70_3; 1.
PE 3: Inferred from homology;
KW ATP-binding; Chaperone; Nucleotide-binding; Reference proteome; Repeat.
FT CHAIN 1..650
FT /note="Chaperone protein HscA"
FT /id="PRO_0000078657"
FT REPEAT 46..50
FT /note="1"
FT REPEAT 51..56
FT /note="2"
FT REPEAT 57..62
FT /note="3"
FT REPEAT 63..68
FT /note="4"
FT REPEAT 69..74
FT /note="5"
FT REPEAT 75..79
FT /note="6"
FT REGION 49..82
FT /note="Insert"
FT VARIANT 46..50
FT /note="Missing (in strain: 91001)"
FT VARIANT 57..62
FT /note="Missing (in strain: KIM5)"
SQ SEQUENCE 650 AA; 69210 MW; 398322578B9B7F3B CRC64;
MALLQISEPG LTAAPHQRRL AAGIDLGTTN SLVATVRSGK AQTLADEQLA DEQLIADEQL
IAGEQLIAGQ QLIAGQQLIN EKQRDLLPSV VHYHPQGIDV GWKARNLAAL DPVNTISSVK
RMMGRSLADI VQRYPNLPYQ FHASENGLPM IQTARGLVNP VQVSAEILKT LAQRAQAALA
GELDGVVITV PAYFDDAQRQ GTKDAARLAG LHVLRLLNEP TAAAIAYGLD SGQEGVIAVY
DLGGGTFDIS ILRLSRGVFE VLATGGDSAL GGDDFDHLLA DWLREQAGVA TRDDHGIQRQ
LLDTAIAAKI ALSEAETAVV SVAGWQGEVT REQLESLIAP QVKRTLMACR RALKDAGVTA
DEILEVVMVG GSTRVPLVRE QVGQFFGRTP LTSIDPDKVV AIGAAIQADI LVGNKPDSDM
LLLDVIPLSL GLETMGGLVE KVIPRNTTIP AARAQEFTTF KDGQSAMMIH VLQGERELVK
DCRSLARFTL RGLPPLPAGG AHIRVTFQVD ADGLLSVTAM EKSTGVEASI QVKPSYGLSD
DEIANMIKDS MANAQSDITA RKLAEQRVDA ARVLESLQGA LAEDAALLSE QESAAIAQAV
ALLQQQMQGS DPQAIEAAIK ALDAQTQDFA ARRMDASIRR ALAGHSVDEV
