ID   AP2S1_MAIZE             Reviewed;         132 AA.
AC   O50016;
DT   10-MAY-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-1998, sequence version 1.
DT   25-MAY-2022, entry version 98.
DE   RecName: Full=AP-2 complex subunit sigma;
DE   AltName: Full=Clathrin assembly protein 2 sigma small chain;
DE   AltName: Full=Clathrin coat assembly protein AP17;
DE   AltName: Full=Clathrin coat-associated protein AP17;
DE   AltName: Full=Plasma membrane adaptor AP-2 17 kDa protein;
DE   AltName: Full=Sigma2-adaptin;
GN   Name=AP-17;
OS   Zea mays (Maize).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; PACMAD clade;
OC   Panicoideae; Andropogonodae; Andropogoneae; Tripsacinae; Zea.
OX   NCBI_TaxID=4577;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND TISSUE SPECIFICITY.
RC   STRAIN=cv. Wisconsin 64; TISSUE=Embryo;
RX   PubMed=9479050; DOI=10.1016/s0378-1119(97)00654-9;
RA   Roca R., Stiefel V., Puigdomenech P.;
RT   "Characterization of the sequence coding for the clathrin coat assembly
RT   protein AP17 (sigma2) associated with the plasma membrane from Zea mays and
RT   constitutive expression of its gene.";
RL   Gene 208:67-72(1998).
CC   -!- FUNCTION: Component of the adaptor complexes which link clathrin to
CC       receptors in coated vesicles. Clathrin-associated protein complexes are
CC       believed to interact with the cytoplasmic tails of membrane proteins,
CC       leading to their selection and concentration. AP2S1/AP17 is a subunit
CC       of the plasma membrane adaptor. The complex binds
CC       polyphosphoinositides.
CC   -!- SUBUNIT: Adaptor protein complex 2 (AP-2) is a heterotetramer composed
CC       of two large adaptins (alpha-type and beta-type subunits), a medium
CC       adaptin (mu-type subunit AP50) and a small adaptin (sigma-type subunit
CC       AP17).
CC   -!- SUBCELLULAR LOCATION: Cell membrane. Membrane, coated pit; Peripheral
CC       membrane protein; Cytoplasmic side. Note=Component of the coat
CC       surrounding the cytoplasmic face of coated vesicles in the plasma
CC       membrane.
CC   -!- TISSUE SPECIFICITY: Widely expressed in the embryo, endosperm, leaf and
CC       root. {ECO:0000269|PubMed:9479050}.
CC   -!- SIMILARITY: Belongs to the adaptor complexes small subunit family.
CC       {ECO:0000305}.
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DR   EMBL; X96758; CAA65533.1; -; Genomic_DNA.
DR   PIR; T02991; T02991.
DR   AlphaFoldDB; O50016; -.
DR   SMR; O50016; -.
DR   STRING; 4577.AC195874.2_FGP002; -.
DR   PaxDb; O50016; -.
DR   eggNOG; KOG0935; Eukaryota.
DR   Proteomes; UP000007305; Unplaced.
DR   ExpressionAtlas; O50016; baseline and differential.
DR   GO; GO:0030122; C:AP-2 adaptor complex; IEA:InterPro.
DR   GO; GO:0043231; C:intracellular membrane-bounded organelle; IBA:GO_Central.
DR   GO; GO:0035615; F:clathrin adaptor activity; IEA:InterPro.
DR   GO; GO:0072583; P:clathrin-dependent endocytosis; IEA:InterPro.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   GO; GO:0016192; P:vesicle-mediated transport; IBA:GO_Central.
DR   CDD; cd14833; AP2_sigma; 1.
DR   InterPro; IPR016635; AP_complex_ssu.
DR   InterPro; IPR022775; AP_mu_sigma_su.
DR   InterPro; IPR027156; APS2.
DR   InterPro; IPR011012; Longin-like_dom_sf.
DR   PANTHER; PTHR11753; PTHR11753; 1.
DR   Pfam; PF01217; Clat_adaptor_s; 1.
DR   PIRSF; PIRSF015588; AP_complex_sigma; 1.
DR   SUPFAM; SSF64356; SSF64356; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Coated pit; Endocytosis; Membrane; Protein transport;
KW   Reference proteome; Transport.
FT   CHAIN           1..132
FT                   /note="AP-2 complex subunit sigma"
FT                   /id="PRO_0000193808"
SQ   SEQUENCE   132 AA;  16015 MW;  3E251CB10CF9FF1F CRC64;
     MIRFILLQNR QGKTRLAKYY VPLEDSEKHK VEYEVHRLVV NRDPKFTNFV EFRTHKVIYR
     RYAGLFFSIC VDITDNELAY LECIHLFVEI LDHFFSNVCE LDLVFNFHKV YRYLILDEFI
     LAGELQETSK RQ