ID   HSDL1_BOVIN             Reviewed;         330 AA.
AC   A5PJF6;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   10-JUL-2007, sequence version 1.
DT   03-AUG-2022, entry version 84.
DE   RecName: Full=Inactive hydroxysteroid dehydrogenase-like protein 1;
GN   Name=HSDL1;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Hypothalamus;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBUNIT: Interacts with STYXL1. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the short-chain dehydrogenases/reductases (SDR)
CC       family. 17-beta-HSD 3 subfamily. {ECO:0000305}.
CC   -!- CAUTION: Although related to the SDR family, lacks the conserved active
CC       Tyr residue in position 218 which is replaced by a Phe, suggesting that
CC       it may lack oxidoreductase activity. {ECO:0000305}.
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DR   EMBL; BC142092; AAI42093.1; -; mRNA.
DR   RefSeq; NP_001092341.1; NM_001098871.1.
DR   RefSeq; XP_005218443.1; XM_005218386.3.
DR   AlphaFoldDB; A5PJF6; -.
DR   SMR; A5PJF6; -.
DR   STRING; 9913.ENSBTAP00000024993; -.
DR   PaxDb; A5PJF6; -.
DR   PRIDE; A5PJF6; -.
DR   Ensembl; ENSBTAT00000024993; ENSBTAP00000024993; ENSBTAG00000018770.
DR   Ensembl; ENSBTAT00000083369; ENSBTAP00000058573; ENSBTAG00000018770.
DR   Ensembl; ENSBTAT00000086154; ENSBTAP00000064149; ENSBTAG00000018770.
DR   GeneID; 505213; -.
DR   KEGG; bta:505213; -.
DR   CTD; 83693; -.
DR   VEuPathDB; HostDB:ENSBTAG00000018770; -.
DR   VGNC; VGNC:29979; HSDL1.
DR   eggNOG; KOG1014; Eukaryota.
DR   GeneTree; ENSGT00940000160053; -.
DR   HOGENOM; CLU_010194_38_0_1; -.
DR   InParanoid; A5PJF6; -.
DR   OMA; SCNCYVE; -.
DR   OrthoDB; 913128at2759; -.
DR   TreeFam; TF314591; -.
DR   Proteomes; UP000009136; Chromosome 18.
DR   Bgee; ENSBTAG00000018770; Expressed in hypothalamus and 103 other tissues.
DR   GO; GO:0045111; C:intermediate filament cytoskeleton; IEA:Ensembl.
DR   GO; GO:0005739; C:mitochondrion; ISS:UniProtKB.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR002347; SDR_fam.
DR   Pfam; PF00106; adh_short; 1.
DR   PRINTS; PR00081; GDHRDH.
DR   PRINTS; PR00080; SDRFAMILY.
DR   SUPFAM; SSF51735; SSF51735; 1.
PE   2: Evidence at transcript level;
KW   Acetylation; Mitochondrion; NADP; Reference proteome.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250|UniProtKB:Q3SXM5"
FT   CHAIN           2..330
FT                   /note="Inactive hydroxysteroid dehydrogenase-like protein
FT                   1"
FT                   /id="PRO_0000313670"
FT   REGION          2..82
FT                   /note="Required for mitochondria translocation"
FT                   /evidence="ECO:0000250"
FT   BINDING         74..80
FT                   /ligand="NADP(+)"
FT                   /ligand_id="ChEBI:CHEBI:58349"
FT                   /evidence="ECO:0000250"
FT   BINDING         125
FT                   /ligand="NADP(+)"
FT                   /ligand_id="ChEBI:CHEBI:58349"
FT                   /evidence="ECO:0000250"
FT   BINDING         222
FT                   /ligand="NADP(+)"
FT                   /ligand_id="ChEBI:CHEBI:58349"
FT                   /evidence="ECO:0000250"
FT   MOD_RES         2
FT                   /note="N-acetylalanine"
FT                   /evidence="ECO:0000250|UniProtKB:Q3SXM5"
SQ   SEQUENCE   330 AA;  37014 MW;  A14B3316CA125B1F CRC64;
     MAAVDSFYLL YREIARSCNC YIEALALVGA WYTARKSITV VCDFYSLIRL HFIPRLVSRA
     DLIKQYGRWA VVSGATDGIG RAYAEELASR GLNIVLISRS QEKLQMVAKD IADTYKVETD
     IIVADFSSGR EIYDMIREAL QDRDIGILVN NVGVFYPYPQ YFTQVSEDTL WDIVNVNIAA
     ASLMVHIVLP GMVERKKGAI VTISSGSCCK PTPQLAAFSA SKAYLDHFSR ALQYEYASKG
     IFVQSLIPFY VATNVATPGS FLHKCPWLVP SPKVYAHHAV STLGISKRTT GYWSHSIQFL
     FAQYMPEWLW VWGANILNRS LRKEALSCKA