ID   HSDL1_CHICK             Reviewed;         331 AA.
AC   Q5ZJG8;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   03-AUG-2022, entry version 91.
DE   RecName: Full=Hydroxysteroid dehydrogenase-like protein 1;
DE            EC=1.1.1.-;
GN   Name=HSDL1; ORFNames=RCJMB04_18f7;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=CB; TISSUE=Bursa of Fabricius;
RX   PubMed=15642098; DOI=10.1186/gb-2004-6-1-r6;
RA   Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P.,
RA   Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P.,
RA   Hayashizaki Y., Buerstedde J.-M.;
RT   "Full-length cDNAs from chicken bursal lymphocytes to facilitate gene
RT   function analysis.";
RL   Genome Biol. 6:R6.1-R6.9(2005).
CC   -!- FUNCTION: May catalyze the metabolism of steroid hormones and thus play
CC       an important role in sex differentiation, the emergence and maintenance
CC       of the secondary sexual characters, and the regulation of endocrine.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the short-chain dehydrogenases/reductases (SDR)
CC       family. 17-beta-HSD 3 subfamily. {ECO:0000305}.
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DR   EMBL; AJ720466; CAG32125.1; -; mRNA.
DR   RefSeq; NP_001005837.1; NM_001005837.1.
DR   AlphaFoldDB; Q5ZJG8; -.
DR   SMR; Q5ZJG8; -.
DR   PaxDb; Q5ZJG8; -.
DR   GeneID; 415703; -.
DR   KEGG; gga:415703; -.
DR   CTD; 83693; -.
DR   VEuPathDB; HostDB:geneid_415703; -.
DR   InParanoid; Q5ZJG8; -.
DR   OrthoDB; 913128at2759; -.
DR   PhylomeDB; Q5ZJG8; -.
DR   PRO; PR:Q5ZJG8; -.
DR   Proteomes; UP000000539; Unplaced.
DR   GO; GO:0005783; C:endoplasmic reticulum; IBA:GO_Central.
DR   GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR   GO; GO:0030497; P:fatty acid elongation; IBA:GO_Central.
DR   GO; GO:0006694; P:steroid biosynthetic process; IEA:UniProtKB-KW.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR002347; SDR_fam.
DR   Pfam; PF00106; adh_short; 1.
DR   PRINTS; PR00081; GDHRDH.
DR   PRINTS; PR00080; SDRFAMILY.
DR   SUPFAM; SSF51735; SSF51735; 1.
PE   2: Evidence at transcript level;
KW   Lipid biosynthesis; Lipid metabolism; Mitochondrion; NADP; Oxidoreductase;
KW   Reference proteome; Steroid biosynthesis.
FT   CHAIN           1..331
FT                   /note="Hydroxysteroid dehydrogenase-like protein 1"
FT                   /id="PRO_0000313675"
FT   REGION          2..82
FT                   /note="Required for mitochondria translocation"
FT                   /evidence="ECO:0000250"
FT   ACT_SITE        218
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000250"
FT   BINDING         74..80
FT                   /ligand="NADP(+)"
FT                   /ligand_id="ChEBI:CHEBI:58349"
FT                   /evidence="ECO:0000250"
FT   BINDING         125
FT                   /ligand="NADP(+)"
FT                   /ligand_id="ChEBI:CHEBI:58349"
FT                   /evidence="ECO:0000250"
FT   BINDING         205
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000250"
FT   BINDING         222
FT                   /ligand="NADP(+)"
FT                   /ligand_id="ChEBI:CHEBI:58349"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   331 AA;  37608 MW;  6EFE6728386A1EC3 CRC64;
     MAAVDRFNLL YREISRSCSV YIEALAIVGA WYTVRKCLTL VFNTYSMIRL HALPKLVGEI
     DIVKRYGRWA VVTGSTDGIG KAYAEELAKR GVNIILISRS KEKLEAVSRS ISETYKVETD
     FIVADFSKGR EAYQAIKEGL KDREIGILVN NVGLFYTYPD YFTNLSEDML WDMINVNIAS
     ANMMVHIVLP GMVEKRKGAI VNVSSASCCQ PTPMLTTYGA SKAYLDYFSR ALYYEYASKG
     IFVQSLTPFV IATRMVSCSR VTSKRSFFFP SAEEYASHAI STLGLSKRTP GYWKHSIEFT
     LGERLPEWIW AWFAQYFCRI IRKEALTHKA K