HSDL1_MOUSE
ID HSDL1_MOUSE Reviewed; 330 AA.
AC Q8BTX9; Q3U839;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 146.
DE RecName: Full=Inactive hydroxysteroid dehydrogenase-like protein 1;
GN Name=Hsdl1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J, and NOD; TISSUE=Bone marrow, and Thymus;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Brown adipose tissue, Heart, Kidney, Lung, Pancreas, Spleen,
RC and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- SUBUNIT: Interacts with STYXL1. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the short-chain dehydrogenases/reductases (SDR)
CC family. 17-beta-HSD 3 subfamily. {ECO:0000305}.
CC -!- CAUTION: Although it belongs to the SDR family, Phe-218 is present
CC instead of the conserved Tyr which is an active site residue. It is
CC therefore expected that this protein lacks oxidoreductase activity.
CC {ECO:0000305}.
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DR EMBL; AK088412; BAC40340.1; -; mRNA.
DR EMBL; AK150638; BAE29726.1; -; mRNA.
DR EMBL; AK152392; BAE31180.1; -; mRNA.
DR EMBL; BC065074; AAH65074.1; -; mRNA.
DR CCDS; CCDS22708.1; -.
DR RefSeq; NP_780394.1; NM_175185.4.
DR RefSeq; XP_006531459.1; XM_006531396.1.
DR RefSeq; XP_006531460.1; XM_006531397.3.
DR AlphaFoldDB; Q8BTX9; -.
DR SMR; Q8BTX9; -.
DR BioGRID; 215432; 2.
DR STRING; 10090.ENSMUSP00000044371; -.
DR PhosphoSitePlus; Q8BTX9; -.
DR SwissPalm; Q8BTX9; -.
DR EPD; Q8BTX9; -.
DR jPOST; Q8BTX9; -.
DR MaxQB; Q8BTX9; -.
DR PaxDb; Q8BTX9; -.
DR PeptideAtlas; Q8BTX9; -.
DR PRIDE; Q8BTX9; -.
DR ProteomicsDB; 273387; -.
DR Antibodypedia; 30543; 64 antibodies from 20 providers.
DR DNASU; 72552; -.
DR Ensembl; ENSMUST00000036049; ENSMUSP00000044371; ENSMUSG00000034189.
DR GeneID; 72552; -.
DR KEGG; mmu:72552; -.
DR UCSC; uc009npu.2; mouse.
DR CTD; 83693; -.
DR MGI; MGI:1919802; Hsdl1.
DR VEuPathDB; HostDB:ENSMUSG00000034189; -.
DR eggNOG; KOG1014; Eukaryota.
DR GeneTree; ENSGT00940000160053; -.
DR HOGENOM; CLU_010194_38_0_1; -.
DR InParanoid; Q8BTX9; -.
DR OMA; SCNCYVE; -.
DR OrthoDB; 913128at2759; -.
DR PhylomeDB; Q8BTX9; -.
DR TreeFam; TF314591; -.
DR BioGRID-ORCS; 72552; 2 hits in 74 CRISPR screens.
DR ChiTaRS; Hsdl1; mouse.
DR PRO; PR:Q8BTX9; -.
DR Proteomes; UP000000589; Chromosome 8.
DR RNAct; Q8BTX9; protein.
DR Bgee; ENSMUSG00000034189; Expressed in otolith organ and 227 other tissues.
DR ExpressionAtlas; Q8BTX9; baseline and differential.
DR Genevisible; Q8BTX9; MM.
DR GO; GO:0045111; C:intermediate filament cytoskeleton; ISO:MGI.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; ISO:MGI.
DR GO; GO:0005739; C:mitochondrion; HDA:MGI.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR002347; SDR_fam.
DR Pfam; PF00106; adh_short; 1.
DR PRINTS; PR00081; GDHRDH.
DR SUPFAM; SSF51735; SSF51735; 1.
PE 1: Evidence at protein level;
KW Acetylation; Mitochondrion; NADP; Reference proteome.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000250|UniProtKB:Q3SXM5"
FT CHAIN 2..330
FT /note="Inactive hydroxysteroid dehydrogenase-like protein
FT 1"
FT /id="PRO_0000313672"
FT REGION 2..82
FT /note="Required for mitochondria translocation"
FT /evidence="ECO:0000250"
FT BINDING 74..80
FT /ligand="NADP(+)"
FT /ligand_id="ChEBI:CHEBI:58349"
FT /evidence="ECO:0000250"
FT BINDING 125
FT /ligand="NADP(+)"
FT /ligand_id="ChEBI:CHEBI:58349"
FT /evidence="ECO:0000250"
FT BINDING 222
FT /ligand="NADP(+)"
FT /ligand_id="ChEBI:CHEBI:58349"
FT /evidence="ECO:0000250"
FT MOD_RES 2
FT /note="N-acetylalanine"
FT /evidence="ECO:0000250|UniProtKB:Q3SXM5"
SQ SEQUENCE 330 AA; 36868 MW; A54D0DB8546DDA00 CRC64;
MAAVDSFYLL YREIARSCNC YMEALALVGA WYTARKSITV ICDFYSLVRL HFIPRLGSRP
DLIKQYGRWA VISGATDGIG KAYAEELASH GLNVILISQE EEKLQAAAKH IADTYRVETL
VLVADFSRGR EIYAPIREAL RDRDIGILVN DVGAFYPYPQ YFSQVPEDTL WDIVNVNIAA
ASLMVHIVLP GMVERKKGAI VTVSSGSCCK PTPQLAAFSA SKAYLDHFSR ALQYEYASKG
IFVQSLIPFY VTSSGAAPAS FLHRCPWLAP SPRVYAQHAV STLGISKRTT GYWSHSIQFL
FAQYMPEWLW VWGANLLNRS LRKEALSCQA
