ID   HSDL1_PONAB             Reviewed;         330 AA.
AC   Q5R7K0;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   03-AUG-2022, entry version 93.
DE   RecName: Full=Inactive hydroxysteroid dehydrogenase-like protein 1;
GN   Name=HSDL1;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain cortex;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBUNIT: Interacts with STYXL1. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the short-chain dehydrogenases/reductases (SDR)
CC       family. 17-beta-HSD 3 subfamily. {ECO:0000305}.
CC   -!- CAUTION: Although it belongs to the SDR family, Phe-218 is present
CC       instead of the conserved Tyr which is an active site residue. It is
CC       therefore expected that this protein lacks oxidoreductase activity.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CR860115; CAH92260.1; -; mRNA.
DR   RefSeq; NP_001126323.1; NM_001132851.1.
DR   RefSeq; XP_009249266.1; XM_009250991.1.
DR   AlphaFoldDB; Q5R7K0; -.
DR   SMR; Q5R7K0; -.
DR   STRING; 9601.ENSPPYP00000008575; -.
DR   Ensembl; ENSPPYT00000008923; ENSPPYP00000008575; ENSPPYG00000007598.
DR   GeneID; 100173303; -.
DR   KEGG; pon:100173303; -.
DR   CTD; 83693; -.
DR   eggNOG; KOG1014; Eukaryota.
DR   GeneTree; ENSGT00940000160053; -.
DR   HOGENOM; CLU_010194_38_0_1; -.
DR   InParanoid; Q5R7K0; -.
DR   OMA; SCNCYVE; -.
DR   OrthoDB; 913128at2759; -.
DR   TreeFam; TF314591; -.
DR   Proteomes; UP000001595; Chromosome 16.
DR   GO; GO:0045111; C:intermediate filament cytoskeleton; IEA:Ensembl.
DR   GO; GO:0005739; C:mitochondrion; ISS:UniProtKB.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR002347; SDR_fam.
DR   Pfam; PF00106; adh_short; 1.
DR   PRINTS; PR00081; GDHRDH.
DR   PRINTS; PR00080; SDRFAMILY.
DR   SUPFAM; SSF51735; SSF51735; 1.
PE   2: Evidence at transcript level;
KW   Acetylation; Mitochondrion; NADP; Reference proteome.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250|UniProtKB:Q3SXM5"
FT   CHAIN           2..330
FT                   /note="Inactive hydroxysteroid dehydrogenase-like protein
FT                   1"
FT                   /id="PRO_0000313673"
FT   REGION          2..82
FT                   /note="Required for mitochondria translocation"
FT                   /evidence="ECO:0000250"
FT   BINDING         74..80
FT                   /ligand="NADP(+)"
FT                   /ligand_id="ChEBI:CHEBI:58349"
FT                   /evidence="ECO:0000250"
FT   BINDING         125
FT                   /ligand="NADP(+)"
FT                   /ligand_id="ChEBI:CHEBI:58349"
FT                   /evidence="ECO:0000250"
FT   BINDING         222
FT                   /ligand="NADP(+)"
FT                   /ligand_id="ChEBI:CHEBI:58349"
FT                   /evidence="ECO:0000250"
FT   MOD_RES         2
FT                   /note="N-acetylalanine"
FT                   /evidence="ECO:0000250|UniProtKB:Q3SXM5"
SQ   SEQUENCE   330 AA;  36959 MW;  5562F726A9BB2996 CRC64;
     MAAVDSFYLL YREIARSCNC YMEALALVGA WYTARKSITV ICDFYSLIRL HFIPRLGSRA
     DLIKQYGRWA VVSGATDGIG RAYAEELASR GLNIILISRN EEKLQVVAKD IADTYKVETG
     IIVADFSSGR EIYLPIREAL KDKDIGILVN NVGVFYPYPQ YFTQLSEDKL WDIINVNIAA
     ASLMVHVVLP GMVERKKGAI VTISSGSCCK PTPQLAAFSA SKAYLDHFSR ALQYEYASKG
     IFVQSLIPFY VATSMTAPSS FLHRCSWLVP SPKVYAHHAV STLGISKRTT GYWSHSIQFL
     FAQYMPEWLW VWGANILNRS LRKEALSCTA