ID   HSDL2_BOVIN             Reviewed;         418 AA.
AC   A4FUZ6; A6QPZ9;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   17-APR-2007, sequence version 1.
DT   03-AUG-2022, entry version 89.
DE   RecName: Full=Hydroxysteroid dehydrogenase-like protein 2;
DE            EC=1.-.-.-;
GN   Name=HSDL2;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Fetal cerebellum, and Fetal skin;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Has apparently no steroid dehydrogenase activity.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Peroxisome {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the short-chain dehydrogenases/reductases (SDR)
CC       family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAI49575.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; BC123507; AAI23508.1; -; mRNA.
DR   EMBL; BC149574; AAI49575.1; ALT_INIT; mRNA.
DR   RefSeq; NP_001098433.1; NM_001104963.1.
DR   AlphaFoldDB; A4FUZ6; -.
DR   SMR; A4FUZ6; -.
DR   STRING; 9913.ENSBTAP00000041845; -.
DR   PaxDb; A4FUZ6; -.
DR   PeptideAtlas; A4FUZ6; -.
DR   PRIDE; A4FUZ6; -.
DR   Ensembl; ENSBTAT00000044340; ENSBTAP00000041845; ENSBTAG00000031295.
DR   GeneID; 404131; -.
DR   KEGG; bta:404131; -.
DR   CTD; 84263; -.
DR   VEuPathDB; HostDB:ENSBTAG00000031295; -.
DR   VGNC; VGNC:29980; HSDL2.
DR   eggNOG; KOG0725; Eukaryota.
DR   eggNOG; KOG4170; Eukaryota.
DR   GeneTree; ENSGT00940000156729; -.
DR   HOGENOM; CLU_010194_25_0_1; -.
DR   InParanoid; A4FUZ6; -.
DR   OMA; KFGMSLC; -.
DR   OrthoDB; 1361949at2759; -.
DR   TreeFam; TF101523; -.
DR   Proteomes; UP000009136; Chromosome 8.
DR   Bgee; ENSBTAG00000031295; Expressed in adult mammalian kidney and 106 other tissues.
DR   ExpressionAtlas; A4FUZ6; baseline and differential.
DR   GO; GO:0005739; C:mitochondrion; IBA:GO_Central.
DR   GO; GO:0005777; C:peroxisome; IEA:UniProtKB-SubCell.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.1050.10; -; 1.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR003033; SCP2_sterol-bd_dom.
DR   InterPro; IPR036527; SCP2_sterol-bd_dom_sf.
DR   InterPro; IPR002347; SDR_fam.
DR   Pfam; PF00106; adh_short; 1.
DR   Pfam; PF02036; SCP2; 1.
DR   PRINTS; PR00081; GDHRDH.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   SUPFAM; SSF55718; SSF55718; 1.
PE   2: Evidence at transcript level;
KW   Acetylation; Hydroxylation; NADP; Oxidoreductase; Peroxisome;
KW   Reference proteome.
FT   CHAIN           1..418
FT                   /note="Hydroxysteroid dehydrogenase-like protein 2"
FT                   /id="PRO_0000319887"
FT   DOMAIN          306..415
FT                   /note="SCP2"
FT   ACT_SITE        168
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000255"
FT   BINDING         17..23
FT                   /ligand="NADP(+)"
FT                   /ligand_id="ChEBI:CHEBI:58349"
FT                   /evidence="ECO:0000250"
FT   BINDING         42
FT                   /ligand="NADP(+)"
FT                   /ligand_id="ChEBI:CHEBI:58349"
FT                   /evidence="ECO:0000250"
FT   BINDING         74
FT                   /ligand="NADP(+)"
FT                   /ligand_id="ChEBI:CHEBI:58349"
FT                   /evidence="ECO:0000250"
FT   BINDING         172
FT                   /ligand="NADP(+)"
FT                   /ligand_id="ChEBI:CHEBI:58349"
FT                   /evidence="ECO:0000250"
FT   MOD_RES         42
FT                   /note="N6-(2-hydroxyisobutyryl)lysine"
FT                   /evidence="ECO:0000250|UniProtKB:Q6YN16"
FT   MOD_RES         116
FT                   /note="N6-acetyllysine"
FT                   /evidence="ECO:0000250|UniProtKB:Q2TPA8"
FT   MOD_RES         318
FT                   /note="N6-succinyllysine"
FT                   /evidence="ECO:0000250|UniProtKB:Q2TPA8"
SQ   SEQUENCE   418 AA;  45150 MW;  51EE9AD3ADADE97E CRC64;
     MLPNTGKLAG CTVFITGASR GIGKAIALKA AKDGANIVIA AKTAQAHPKL PGTIYTAAEE
     IKAAGGKALP CIVDVRDEEQ ISSAVEKAVE KFGGIDILVN NASAISLTNT LETPTKKVDL
     MMNVNTRGTY LTSKACIPYL KKSKVAHILN LSPPLNLNPL WFKQHCAYTI AKYGMSMCVL
     GMAEEFKGEI AVNALWPRTA IHTAAMDMLG GSGVESQCRK VDIMADAAYC IFKKPKSFTG
     NFIIDENILK EEGIKNFDVY AITPGHPLLP DFFLDEQPAM VTKKADSYGA VPELKEEKTQ
     PPPKARSGAV EETFRIVKDS LSDDIVKATQ AVYQFELSGE DGGTWFLDLK SKGGNIGYGE
     PSDQADVVMS MSTDDFVKMF SGKLKPTMAF MSGKLKIKGN MALAIKLEKL MNQMNSKL