ID   HSDL2_DANRE             Reviewed;         415 AA.
AC   Q6P5L8;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 109.
DE   RecName: Full=Hydroxysteroid dehydrogenase-like protein 2;
DE            EC=1.-.-.-;
GN   Name=hsdl2;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (NOV-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Has apparently no steroid dehydrogenase activity.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Peroxisome {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the short-chain dehydrogenases/reductases (SDR)
CC       family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BC062838; AAH62838.1; -; mRNA.
DR   RefSeq; NP_955893.1; NM_199599.2.
DR   RefSeq; XP_005155648.1; XM_005155591.3.
DR   RefSeq; XP_005155649.1; XM_005155592.3.
DR   AlphaFoldDB; Q6P5L8; -.
DR   SMR; Q6P5L8; -.
DR   STRING; 7955.ENSDARP00000129592; -.
DR   PaxDb; Q6P5L8; -.
DR   DNASU; 322347; -.
DR   Ensembl; ENSDART00000038888; ENSDARP00000038205; ENSDARG00000002523.
DR   Ensembl; ENSDART00000155742; ENSDARP00000129592; ENSDARG00000002523.
DR   GeneID; 322347; -.
DR   KEGG; dre:322347; -.
DR   CTD; 84263; -.
DR   ZFIN; ZDB-GENE-030131-1066; hsdl2.
DR   eggNOG; KOG0725; Eukaryota.
DR   eggNOG; KOG4170; Eukaryota.
DR   GeneTree; ENSGT00940000156729; -.
DR   HOGENOM; CLU_010194_25_0_1; -.
DR   InParanoid; Q6P5L8; -.
DR   OrthoDB; 1361949at2759; -.
DR   PhylomeDB; Q6P5L8; -.
DR   TreeFam; TF101523; -.
DR   PRO; PR:Q6P5L8; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 10.
DR   Bgee; ENSDARG00000002523; Expressed in mature ovarian follicle and 28 other tissues.
DR   ExpressionAtlas; Q6P5L8; baseline and differential.
DR   GO; GO:0005739; C:mitochondrion; IBA:GO_Central.
DR   GO; GO:0005777; C:peroxisome; IEA:UniProtKB-SubCell.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.1050.10; -; 1.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR003033; SCP2_sterol-bd_dom.
DR   InterPro; IPR036527; SCP2_sterol-bd_dom_sf.
DR   InterPro; IPR002347; SDR_fam.
DR   Pfam; PF00106; adh_short; 1.
DR   Pfam; PF02036; SCP2; 1.
DR   PRINTS; PR00081; GDHRDH.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   SUPFAM; SSF55718; SSF55718; 1.
PE   2: Evidence at transcript level;
KW   NADP; Oxidoreductase; Peroxisome; Reference proteome.
FT   CHAIN           1..415
FT                   /note="Hydroxysteroid dehydrogenase-like protein 2"
FT                   /id="PRO_0000319892"
FT   DOMAIN          304..412
FT                   /note="SCP2"
FT   ACT_SITE        168
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000255"
FT   BINDING         17..23
FT                   /ligand="NADP(+)"
FT                   /ligand_id="ChEBI:CHEBI:58349"
FT                   /evidence="ECO:0000250"
FT   BINDING         42
FT                   /ligand="NADP(+)"
FT                   /ligand_id="ChEBI:CHEBI:58349"
FT                   /evidence="ECO:0000250"
FT   BINDING         74
FT                   /ligand="NADP(+)"
FT                   /ligand_id="ChEBI:CHEBI:58349"
FT                   /evidence="ECO:0000250"
FT   BINDING         172
FT                   /ligand="NADP(+)"
FT                   /ligand_id="ChEBI:CHEBI:58349"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   415 AA;  44421 MW;  B8BAC424D4E7CC61 CRC64;
     MLQNTGKLAG CTIFITGASR GIGKAIALKA AQDGANVVIA AKTADPHPKL PGTIYTAAAE
     IEAAGGKALP CIVDVRDEKQ INDAVEQAVE KFGGIDILVN NASAINLTGT LQTPMKKADL
     MLGINLRGTY LTSKLCIPHL LKSKNPHILN LSPPLNLNPI WFKNHTAYTI AKYGMSMCVL
     GMAEEFRGSI AVNALWPKTA IQTAAMDMLG GSEVGKQCRK VEIMADAAYA IFKQPTSFTG
     QFVIDEDILK KEGIKDFDVY AVEPGHPLLP DFFLDGQPED LVKHMEAHGA TPAFTTAKAD
     PVAAGPVSEM FNTIRGIISP EMVKTTQGVY KFNLAGEHAG VWYLDLKNDA GSAGNGEPPV
     KADVVMSMDS EDFVKMFGGK LKPTMAFMSG KLTIKGDMGL AIKLEKMMAM MKSKL