ID   HSDL2_XENLA             Reviewed;         417 AA.
AC   Q6PAY8;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 82.
DE   RecName: Full=Hydroxysteroid dehydrogenase-like protein 2;
DE            EC=1.-.-.-;
GN   Name=hsdl2;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Has apparently no steroid dehydrogenase activity.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Peroxisome {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the short-chain dehydrogenases/reductases (SDR)
CC       family. {ECO:0000305}.
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DR   EMBL; BC059996; AAH59996.1; -; mRNA.
DR   RefSeq; NP_001083285.1; NM_001089816.1.
DR   RefSeq; XP_018095304.1; XM_018239815.1.
DR   AlphaFoldDB; Q6PAY8; -.
DR   SMR; Q6PAY8; -.
DR   IntAct; Q6PAY8; 2.
DR   MaxQB; Q6PAY8; -.
DR   DNASU; 398845; -.
DR   GeneID; 398845; -.
DR   KEGG; xla:398845; -.
DR   CTD; 398845; -.
DR   OrthoDB; 1361949at2759; -.
DR   Proteomes; UP000186698; Chromosome 1S.
DR   Bgee; 398845; Expressed in muscle tissue and 19 other tissues.
DR   GO; GO:0005777; C:peroxisome; IEA:UniProtKB-SubCell.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.1050.10; -; 1.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR003033; SCP2_sterol-bd_dom.
DR   InterPro; IPR036527; SCP2_sterol-bd_dom_sf.
DR   InterPro; IPR002347; SDR_fam.
DR   Pfam; PF00106; adh_short; 1.
DR   Pfam; PF02036; SCP2; 1.
DR   PRINTS; PR00081; GDHRDH.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   SUPFAM; SSF55718; SSF55718; 1.
PE   2: Evidence at transcript level;
KW   NADP; Oxidoreductase; Peroxisome; Reference proteome.
FT   CHAIN           1..417
FT                   /note="Hydroxysteroid dehydrogenase-like protein 2"
FT                   /id="PRO_0000319893"
FT   DOMAIN          306..414
FT                   /note="SCP2"
FT   ACT_SITE        168
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000255"
FT   BINDING         17..23
FT                   /ligand="NADP(+)"
FT                   /ligand_id="ChEBI:CHEBI:58349"
FT                   /evidence="ECO:0000250"
FT   BINDING         42
FT                   /ligand="NADP(+)"
FT                   /ligand_id="ChEBI:CHEBI:58349"
FT                   /evidence="ECO:0000250"
FT   BINDING         74
FT                   /ligand="NADP(+)"
FT                   /ligand_id="ChEBI:CHEBI:58349"
FT                   /evidence="ECO:0000250"
FT   BINDING         172
FT                   /ligand="NADP(+)"
FT                   /ligand_id="ChEBI:CHEBI:58349"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   417 AA;  44560 MW;  A82EB3A8C637B64B CRC64;
     MLPNTGKLAG CTLFITGASR GIGKAIALKA ARDGANIVVA AKTAEAHPKL PGTIYTAASE
     IEAAGGKALP CIVDVRDENQ ISAAVEKAVD AFGGIDILVN NASAISLTNT LETSMKKVDL
     MMGINTRGTY LTSKICIPYL KKSKVAHILN LSPPLNLNPM WFKNHCAYTI AKYGMSMCAL
     GMSEEYKGEI AVNALWPKTA IHTAAMDMLG GSGVDKQCRK PDIMADAAYA ILTKTKDFTG
     NFVIDEELLQ QEGIKDLDVY AISPGHPLLP DFFLDESPET LASAMEEHGA TAAFKAGKKQ
     AKSQDASPLQ ETFKAIERSV NEEAVKSTQG IYQFVLSGEE SGNWFLDLKN DKGGVGKGEP
     STKADVVMSM DSGDFIKMFA GKMKPTMAFM SGKLKIKGDM GLALKLEKIL GQMNAKL