ID   HSDL2_XENTR             Reviewed;         417 AA.
AC   Q66KC4;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   03-AUG-2022, entry version 94.
DE   RecName: Full=Hydroxysteroid dehydrogenase-like protein 2;
DE            EC=1.-.-.-;
GN   Name=hsdl2;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Has apparently no steroid dehydrogenase activity.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Peroxisome {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the short-chain dehydrogenases/reductases (SDR)
CC       family. {ECO:0000305}.
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DR   EMBL; BC080462; AAH80462.1; -; mRNA.
DR   RefSeq; NP_001008673.1; NM_001008673.1.
DR   RefSeq; XP_017948001.1; XM_018092512.1.
DR   AlphaFoldDB; Q66KC4; -.
DR   SMR; Q66KC4; -.
DR   PaxDb; Q66KC4; -.
DR   DNASU; 493329; -.
DR   GeneID; 493329; -.
DR   KEGG; xtr:493329; -.
DR   CTD; 84263; -.
DR   eggNOG; KOG0725; Eukaryota.
DR   eggNOG; KOG4170; Eukaryota.
DR   InParanoid; Q66KC4; -.
DR   OrthoDB; 1361949at2759; -.
DR   Proteomes; UP000008143; Chromosome 1.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000002228; Expressed in skeletal muscle tissue and 13 other tissues.
DR   ExpressionAtlas; Q66KC4; baseline.
DR   GO; GO:0005777; C:peroxisome; IEA:UniProtKB-SubCell.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.1050.10; -; 1.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR003033; SCP2_sterol-bd_dom.
DR   InterPro; IPR036527; SCP2_sterol-bd_dom_sf.
DR   InterPro; IPR002347; SDR_fam.
DR   Pfam; PF00106; adh_short; 1.
DR   Pfam; PF02036; SCP2; 1.
DR   PRINTS; PR00081; GDHRDH.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   SUPFAM; SSF55718; SSF55718; 1.
PE   2: Evidence at transcript level;
KW   NADP; Oxidoreductase; Peroxisome; Reference proteome.
FT   CHAIN           1..417
FT                   /note="Hydroxysteroid dehydrogenase-like protein 2"
FT                   /id="PRO_0000319894"
FT   DOMAIN          306..414
FT                   /note="SCP2"
FT   ACT_SITE        168
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000255"
FT   BINDING         17..23
FT                   /ligand="NADP(+)"
FT                   /ligand_id="ChEBI:CHEBI:58349"
FT                   /evidence="ECO:0000250"
FT   BINDING         42
FT                   /ligand="NADP(+)"
FT                   /ligand_id="ChEBI:CHEBI:58349"
FT                   /evidence="ECO:0000250"
FT   BINDING         74
FT                   /ligand="NADP(+)"
FT                   /ligand_id="ChEBI:CHEBI:58349"
FT                   /evidence="ECO:0000250"
FT   BINDING         172
FT                   /ligand="NADP(+)"
FT                   /ligand_id="ChEBI:CHEBI:58349"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   417 AA;  44362 MW;  4227D9E156EE3302 CRC64;
     MLPNTGKLAG CTLFITGASR GIGKAIALKA ARDGANVVIA AKTAEAHPKL PGTIYTAASE
     IEAAGGKALP CIVDVRDENQ ISAAVEKAVD TFGGIDILVN NASAISLTNT LETPMKKVDL
     MMGINTRGTY LTSKICIPYL KKSKVAHILN LSPPLNLNPI WFKNHCAYTI AKYGMSMCAL
     GMSEEYKGEI AVNALWPKTA IHTAAMDMLG GSGVDKQCRT PDIMADAAYA ILSKPKDFTG
     NFVIDEELLK HEGIKDLDVY AVSPGHPLLP DFFLDESPEA LASAMEEHGA TAAFKAGKAQ
     AKSQDSSPLQ ETFKAIESLV NEEAVKTTQG IYQFVLSGEE SGNWFLDLKN GKGGVGSGEP
     STKADVVMSM DSGDFIKMFT GKMKPTMAFM SGKLKIKGDM GLALKLEKIL GQMNAKL