HSFA8_ARATH
ID HSFA8_ARATH Reviewed; 374 AA.
AC Q9S7U5;
DT 01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 25-MAY-2022, entry version 146.
DE RecName: Full=Heat stress transcription factor A-8;
DE Short=AtHsfA8;
DE AltName: Full=AtHsf-03;
DE AltName: Full=Heat shock factor protein 5;
DE Short=HSF 5;
DE AltName: Full=Heat shock transcription factor 5;
DE Short=HSTF 5;
GN Name=HSFA8; Synonyms=HSF03, HSF5; OrderedLocusNames=At1g67970;
GN ORFNames=T23K23.18;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=cv. Columbia; TISSUE=Green siliques;
RA Schoeffl F., Praendl R.;
RT "De-repression of heat shock protein synthesis in transgenic plants.";
RL (In) Smallwood M.F., Calvert C.M., Bowles D.J. (eds.);
RL Plant responses to environmental stress, pp.65-73, BIOS Scientific
RL Publishers, Oxford (1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [5]
RP GENE FAMILY, NOMENCLATURE, AND DOMAIN AHA.
RX PubMed=11599559; DOI=10.1379/1466-1268(2001)006<0177:aathst>2.0.co;2;
RA Nover L., Bharti K., Doering P., Mishra S.K., Ganguli A., Scharf K.-D.;
RT "Arabidopsis and the heat stress transcription factor world: how many heat
RT stress transcription factors do we need?";
RL Cell Stress Chaperones 6:177-189(2001).
RN [6]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=18407058; DOI=10.1016/s1673-8527(08)60016-8;
RA Guo J., Wu J., Ji Q., Wang C., Luo L., Yuan Y., Wang Y., Wang J.;
RT "Genome-wide analysis of heat shock transcription factor families in rice
RT and Arabidopsis.";
RL J. Genet. Genomics 35:105-118(2008).
CC -!- FUNCTION: Transcriptional activator that specifically binds DNA
CC sequence 5'-AGAAnnTTCT-3' known as heat shock promoter elements (HSE).
CC -!- SUBUNIT: Homotrimer. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. Nucleus {ECO:0000305}.
CC -!- DOMAIN: The hydrophobic-rich region (HR-A/B) corresponds to the
CC oligomerization domain. AHA motifs are transcriptional activator
CC elements. {ECO:0000269|PubMed:11599559}.
CC -!- PTM: Exhibits temperature-dependent phosphorylation. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the HSF family. Class A subfamily.
CC {ECO:0000305}.
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DR EMBL; AJ251866; CAB63801.1; -; mRNA.
DR EMBL; AC012563; AAG51992.1; -; Genomic_DNA.
DR EMBL; CP002684; AEE34730.1; -; Genomic_DNA.
DR EMBL; AY094396; AAM19775.1; -; mRNA.
DR PIR; F96702; F96702.
DR RefSeq; NP_176964.1; NM_105467.4.
DR AlphaFoldDB; Q9S7U5; -.
DR SMR; Q9S7U5; -.
DR BioGRID; 28346; 2.
DR STRING; 3702.AT1G67970.1; -.
DR PaxDb; Q9S7U5; -.
DR PRIDE; Q9S7U5; -.
DR ProteomicsDB; 230152; -.
DR EnsemblPlants; AT1G67970.1; AT1G67970.1; AT1G67970.
DR GeneID; 843125; -.
DR Gramene; AT1G67970.1; AT1G67970.1; AT1G67970.
DR KEGG; ath:AT1G67970; -.
DR Araport; AT1G67970; -.
DR TAIR; locus:2200171; AT1G67970.
DR eggNOG; KOG0627; Eukaryota.
DR HOGENOM; CLU_030308_1_2_1; -.
DR InParanoid; Q9S7U5; -.
DR OMA; RRRKHPH; -.
DR OrthoDB; 1154048at2759; -.
DR PhylomeDB; Q9S7U5; -.
DR PRO; PR:Q9S7U5; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q9S7U5; baseline and differential.
DR Genevisible; Q9S7U5; AT.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:TAIR.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0000976; F:transcription cis-regulatory region binding; IPI:TAIR.
DR GO; GO:0034605; P:cellular response to heat; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR Gene3D; 1.10.10.10; -; 1.
DR InterPro; IPR000232; HSF_DNA-bd.
DR InterPro; IPR027725; HSF_fam.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR10015; PTHR10015; 1.
DR Pfam; PF00447; HSF_DNA-bind; 1.
DR PRINTS; PR00056; HSFDOMAIN.
DR SMART; SM00415; HSF; 1.
DR SUPFAM; SSF46785; SSF46785; 1.
DR PROSITE; PS00434; HSF_DOMAIN; 1.
PE 2: Evidence at transcript level;
KW Activator; Cytoplasm; DNA-binding; Nucleus; Phosphoprotein;
KW Reference proteome; Repeat; Stress response; Transcription;
KW Transcription regulation.
FT CHAIN 1..374
FT /note="Heat stress transcription factor A-8"
FT /id="PRO_0000124586"
FT DNA_BIND 17..112
FT /evidence="ECO:0000250"
FT REGION 126..192
FT /note="Hydrophobic repeat HR-A/B"
FT MOTIF 285..294
FT /note="AHA1"
FT MOTIF 298..303
FT /note="Nuclear localization signal"
FT /evidence="ECO:0000255"
FT MOTIF 330..339
FT /note="AHA2"
FT MOTIF 363..370
FT /note="Nuclear export signal"
FT /evidence="ECO:0000255"
SQ SEQUENCE 374 AA; 42630 MW; 401A924CBFEEB512 CRC64;
MVKSTDGGGG SSSSSSVAPF LRKCYDMVDD STTDSIISWS PSADNSFVIL DTTVFSVQLL
PKYFKHSNFS SFIRQLNIYG FRKVDADRWE FANDGFVRGQ KDLLKNVIRR KNVQSSEQSK
HESTSTTYAQ EKSGLWKEVD ILKGDKQVLA QELIKVRQYQ EVTDTKMLHL EDRVQGMEES
QQEMLSFLVM VMKNPSLLVQ LLQPKEKNTW RKAGEGAKIV EEVTDEGESN SYGLPLVTYQ
PPSDNNGTAK SNSNDVNDFL RNADMLKFCL DENHVPLIIP DLYDDGAWEK LLLLSPSRKK
TKKQENIVKK GKDDLTLEEE EEDGTMELDK SYMLKLISEE MEKPDDFEFG QLTPERSRNL
EILTEQMELL ASNE