HSFB3_ARATH
ID HSFB3_ARATH Reviewed; 244 AA.
AC O22230;
DT 09-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-JAN-1998, sequence version 1.
DT 03-AUG-2022, entry version 151.
DE RecName: Full=Heat stress transcription factor B-3;
DE Short=AtHsfB3;
DE AltName: Full=AtHsf-05;
GN Name=HSFB3; Synonyms=HSF05; OrderedLocusNames=At2g41690; ORFNames=T32G6.21;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617197; DOI=10.1038/45471;
RA Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S.,
RA Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL Nature 402:761-768(1999).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Bautista V.R., Kim C.J., Chen H., Quinitio C., Ecker J.R.;
RT "Arabidopsis ORF clones.";
RL Submitted (NOV-2006) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=11599559; DOI=10.1379/1466-1268(2001)006<0177:aathst>2.0.co;2;
RA Nover L., Bharti K., Doering P., Mishra S.K., Ganguli A., Scharf K.-D.;
RT "Arabidopsis and the heat stress transcription factor world: how many heat
RT stress transcription factors do we need?";
RL Cell Stress Chaperones 6:177-189(2001).
RN [5]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=18407058; DOI=10.1016/s1673-8527(08)60016-8;
RA Guo J., Wu J., Ji Q., Wang C., Luo L., Yuan Y., Wang Y., Wang J.;
RT "Genome-wide analysis of heat shock transcription factor families in rice
RT and Arabidopsis.";
RL J. Genet. Genomics 35:105-118(2008).
CC -!- FUNCTION: Transcriptional regulator that specifically binds DNA
CC sequence 5'-AGAAnnTTCT-3' known as heat shock promoter elements (HSE).
CC -!- SUBUNIT: Homotrimer. {ECO:0000250}.
CC -!- INTERACTION:
CC O22230; F4JI72: At4g03250; NbExp=3; IntAct=EBI-15192145, EBI-15192535;
CC O22230; Q93Z00: TCP14; NbExp=4; IntAct=EBI-15192145, EBI-4424563;
CC O22230; Q8LPR5: TCP4; NbExp=3; IntAct=EBI-15192145, EBI-15192325;
CC O22230; O64647: TCP9; NbExp=3; IntAct=EBI-15192145, EBI-9838721;
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. Nucleus {ECO:0000305}.
CC -!- DOMAIN: The hydrophobic-rich region (HR-A/B) corresponds to the
CC oligomerization domain.
CC -!- PTM: Exhibits temperature-dependent phosphorylation. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the HSF family. Class B subfamily.
CC {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AC002510; AAB84350.1; -; Genomic_DNA.
DR EMBL; CP002685; AEC10016.1; -; Genomic_DNA.
DR EMBL; BT029452; ABK59681.1; -; mRNA.
DR PIR; T00825; T00825.
DR RefSeq; NP_181700.1; NM_129732.2.
DR AlphaFoldDB; O22230; -.
DR SMR; O22230; -.
DR BioGRID; 4104; 21.
DR IntAct; O22230; 21.
DR STRING; 3702.AT2G41690.1; -.
DR PaxDb; O22230; -.
DR PRIDE; O22230; -.
DR ProteomicsDB; 228751; -.
DR EnsemblPlants; AT2G41690.1; AT2G41690.1; AT2G41690.
DR GeneID; 818767; -.
DR Gramene; AT2G41690.1; AT2G41690.1; AT2G41690.
DR KEGG; ath:AT2G41690; -.
DR Araport; AT2G41690; -.
DR TAIR; locus:2062698; AT2G41690.
DR eggNOG; KOG0627; Eukaryota.
DR HOGENOM; CLU_030308_3_2_1; -.
DR InParanoid; O22230; -.
DR OMA; VTTIRWE; -.
DR OrthoDB; 1154048at2759; -.
DR PhylomeDB; O22230; -.
DR PRO; PR:O22230; -.
DR Proteomes; UP000006548; Chromosome 2.
DR ExpressionAtlas; O22230; baseline and differential.
DR Genevisible; O22230; AT.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:TAIR.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR Gene3D; 1.10.10.10; -; 1.
DR InterPro; IPR000232; HSF_DNA-bd.
DR InterPro; IPR027725; HSF_fam.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR10015; PTHR10015; 1.
DR Pfam; PF00447; HSF_DNA-bind; 1.
DR PRINTS; PR00056; HSFDOMAIN.
DR SMART; SM00415; HSF; 1.
DR SUPFAM; SSF46785; SSF46785; 1.
DR PROSITE; PS00434; HSF_DOMAIN; 1.
PE 1: Evidence at protein level;
KW Cytoplasm; DNA-binding; Nucleus; Phosphoprotein; Reference proteome;
KW Stress response; Transcription; Transcription regulation.
FT CHAIN 1..244
FT /note="Heat stress transcription factor B-3"
FT /id="PRO_0000270812"
FT DNA_BIND 38..132
FT /evidence="ECO:0000250"
FT REGION 173..218
FT /note="Hydrophobic repeat HR-A/B"
FT REGION 216..244
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 202..208
FT /note="Nuclear localization signal"
FT /evidence="ECO:0000255"
FT MOTIF 236..243
FT /note="Nuclear export signal"
FT /evidence="ECO:0000255"
SQ SEQUENCE 244 AA; 28308 MW; FC335FFF2705E948 CRC64;
MEDAGEHLRC NDNVNDEERL PLEFMIGNST STAELQPPPP FLVKTYKVVE DPTTDGVISW
NEYGTGFVVW QPAEFARDLL PTLFKHCNFS SFVRQLNTYG FRKVTTIRWE FSNEMFRKGQ
RELMSNIRRR KSQHWSHNKS NHQVVPTTTM VNQEGHQRIG IDHHHEDQQS SATSSSFVYT
ALLDENKCLK NENELLSCEL GKTKKKCKQL MELVERYRGE DEDATDESDD EEDEGLKLFG
VKLE
