HSFB4_ARATH
ID HSFB4_ARATH Reviewed; 348 AA.
AC Q9C635;
DT 09-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 136.
DE RecName: Full=Heat stress transcription factor B-4;
DE Short=AtHsfB4;
DE AltName: Full=AtHsf-02;
GN Name=HSFB4; Synonyms=HSF02; OrderedLocusNames=At1g46264; ORFNames=F2G19.8;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14993207; DOI=10.1101/gr.1515604;
RA Castelli V., Aury J.-M., Jaillon O., Wincker P., Clepet C., Menard M.,
RA Cruaud C., Quetier F., Scarpelli C., Schaechter V., Temple G., Caboche M.,
RA Weissenbach J., Salanoubat M.;
RT "Whole genome sequence comparisons and 'full-length' cDNA sequences: a
RT combined approach to evaluate and improve Arabidopsis genome annotation.";
RL Genome Res. 14:406-413(2004).
RN [4]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=11599559; DOI=10.1379/1466-1268(2001)006<0177:aathst>2.0.co;2;
RA Nover L., Bharti K., Doering P., Mishra S.K., Ganguli A., Scharf K.-D.;
RT "Arabidopsis and the heat stress transcription factor world: how many heat
RT stress transcription factors do we need?";
RL Cell Stress Chaperones 6:177-189(2001).
RN [5]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=18407058; DOI=10.1016/s1673-8527(08)60016-8;
RA Guo J., Wu J., Ji Q., Wang C., Luo L., Yuan Y., Wang Y., Wang J.;
RT "Genome-wide analysis of heat shock transcription factor families in rice
RT and Arabidopsis.";
RL J. Genet. Genomics 35:105-118(2008).
CC -!- FUNCTION: Transcriptional regulator that specifically binds DNA
CC sequence 5'-AGAAnnTTCT-3' known as heat shock promoter elements (HSE).
CC -!- SUBUNIT: Homotrimer. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. Nucleus {ECO:0000305}.
CC -!- DOMAIN: The hydrophobic-rich region (HR-A/B) corresponds to the
CC oligomerization domain.
CC -!- PTM: Exhibits temperature-dependent phosphorylation. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the HSF family. Class B subfamily.
CC {ECO:0000305}.
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DR EMBL; AC083835; AAG50634.1; -; Genomic_DNA.
DR EMBL; CP002684; AEE32124.1; -; Genomic_DNA.
DR EMBL; BX814533; -; NOT_ANNOTATED_CDS; mRNA.
DR PIR; C96511; C96511.
DR RefSeq; NP_175142.1; NM_103602.3.
DR AlphaFoldDB; Q9C635; -.
DR SMR; Q9C635; -.
DR STRING; 3702.AT1G46264.1; -.
DR PaxDb; Q9C635; -.
DR PRIDE; Q9C635; -.
DR ProteomicsDB; 232111; -.
DR EnsemblPlants; AT1G46264.1; AT1G46264.1; AT1G46264.
DR GeneID; 841110; -.
DR Gramene; AT1G46264.1; AT1G46264.1; AT1G46264.
DR KEGG; ath:AT1G46264; -.
DR Araport; AT1G46264; -.
DR TAIR; locus:2825726; AT1G46264.
DR eggNOG; KOG0627; Eukaryota.
DR HOGENOM; CLU_030308_3_1_1; -.
DR InParanoid; Q9C635; -.
DR OMA; MAMMLDN; -.
DR OrthoDB; 1154048at2759; -.
DR PhylomeDB; Q9C635; -.
DR PRO; PR:Q9C635; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q9C635; baseline and differential.
DR Genevisible; Q9C635; AT.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:TAIR.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0008356; P:asymmetric cell division; IMP:TAIR.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR Gene3D; 1.10.10.10; -; 1.
DR InterPro; IPR000232; HSF_DNA-bd.
DR InterPro; IPR027725; HSF_fam.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR10015; PTHR10015; 1.
DR Pfam; PF00447; HSF_DNA-bind; 1.
DR PRINTS; PR00056; HSFDOMAIN.
DR SMART; SM00415; HSF; 1.
DR SUPFAM; SSF46785; SSF46785; 1.
DR PROSITE; PS00434; HSF_DOMAIN; 1.
PE 2: Evidence at transcript level;
KW Cytoplasm; DNA-binding; Nucleus; Phosphoprotein; Reference proteome;
KW Stress response; Transcription; Transcription regulation.
FT CHAIN 1..348
FT /note="Heat stress transcription factor B-4"
FT /id="PRO_0000270813"
FT DNA_BIND 32..126
FT /evidence="ECO:0000250"
FT REGION 187..232
FT /note="Hydrophobic repeat HR-A/B"
FT MOTIF 303..318
FT /note="Bipartite nuclear localization signal"
FT /evidence="ECO:0000255"
FT MOTIF 338..343
FT /note="Nuclear export signal"
FT /evidence="ECO:0000255"
SQ SEQUENCE 348 AA; 39615 MW; D05B9B2E69B9BE12 CRC64;
MAMMVENSYG GYGGGGGERI QLMVEGQGKA VPAPFLTKTY QLVDDPATDH VVSWGDDDTT
FVVWRPPEFA RDLLPNYFKH NNFSSFVRQL NTYGFRKIVP DRWEFANEFF KRGEKHLLCE
IHRRKTSQMI PQQHSPFMSH HHAPPQIPFS GGSFFPLPPP RVTTPEEDHY WCDDSPPSRP
RVIPQQIDTA AQVTALSEDN ERLRRSNTVL MSELAHMKKL YNDIIYFVQN HVKPVAPSNN
SSYLSSFLQK QQQQQPPTLD YYNTATVNAT NLNALNSSPP TSQSSITVLE DDHTNHHDQS
NMRKTKLFGV SLPSSKKRSH HFSDQTSKTR LVLDQSDLAL NLMTASTR
