HSFC1_ARATH
ID HSFC1_ARATH Reviewed; 330 AA.
AC Q9LV52;
DT 09-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 142.
DE RecName: Full=Heat stress transcription factor C-1;
DE Short=AtHsfC1;
DE AltName: Full=AtHsf-08;
GN Name=HSFC1; Synonyms=HSF08; OrderedLocusNames=At3g24520; ORFNames=MOB24.9;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10907853; DOI=10.1093/dnares/7.3.217;
RA Kaneko T., Katoh T., Sato S., Nakamura Y., Asamizu E., Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 3. II. Sequence
RT features of the 4,251,695 bp regions covered by 90 P1, TAC and BAC
RT clones.";
RL DNA Res. 7:217-221(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=11599559; DOI=10.1379/1466-1268(2001)006<0177:aathst>2.0.co;2;
RA Nover L., Bharti K., Doering P., Mishra S.K., Ganguli A., Scharf K.-D.;
RT "Arabidopsis and the heat stress transcription factor world: how many heat
RT stress transcription factors do we need?";
RL Cell Stress Chaperones 6:177-189(2001).
RN [5]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=18407058; DOI=10.1016/s1673-8527(08)60016-8;
RA Guo J., Wu J., Ji Q., Wang C., Luo L., Yuan Y., Wang Y., Wang J.;
RT "Genome-wide analysis of heat shock transcription factor families in rice
RT and Arabidopsis.";
RL J. Genet. Genomics 35:105-118(2008).
CC -!- FUNCTION: Transcriptional regulator that specifically binds DNA
CC sequence 5'-AGAAnnTTCT-3' known as heat shock promoter elements (HSE).
CC -!- SUBUNIT: Homotrimer. {ECO:0000250}.
CC -!- INTERACTION:
CC Q9LV52; Q9SFD5: ADA2A; NbExp=5; IntAct=EBI-4457746, EBI-979206;
CC Q9LV52; O22286: BPM3; NbExp=5; IntAct=EBI-4457746, EBI-540923;
CC Q9LV52; Q8GYY1: HSFA3; NbExp=3; IntAct=EBI-4457746, EBI-15198195;
CC Q9LV52; Q9SV12: HSFA7A; NbExp=4; IntAct=EBI-4457746, EBI-15200882;
CC Q9LV52; Q8RXD6: HUB1; NbExp=3; IntAct=EBI-4457746, EBI-2012188;
CC Q9LV52; O24408: IAA18; NbExp=3; IntAct=EBI-4457746, EBI-2295525;
CC Q9LV52; Q9LQF0: TCP23; NbExp=3; IntAct=EBI-4457746, EBI-15192297;
CC Q9LV52; Q9SK33: WRKY60; NbExp=3; IntAct=EBI-4457746, EBI-2112777;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- DOMAIN: The hydrophobic-rich region (HR-A/B) corresponds to the
CC oligomerization domain.
CC -!- PTM: Exhibits temperature-dependent phosphorylation. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the HSF family. Class C subfamily.
CC {ECO:0000305}.
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DR EMBL; AB020746; BAB02003.1; -; Genomic_DNA.
DR EMBL; CP002686; AEE76915.1; -; Genomic_DNA.
DR EMBL; AY056111; AAL06998.1; -; mRNA.
DR EMBL; AY072614; AAL62005.1; -; mRNA.
DR RefSeq; NP_189095.1; NM_113363.2.
DR AlphaFoldDB; Q9LV52; -.
DR SMR; Q9LV52; -.
DR BioGRID; 7378; 26.
DR IntAct; Q9LV52; 26.
DR STRING; 3702.AT3G24520.1; -.
DR MetOSite; Q9LV52; -.
DR PaxDb; Q9LV52; -.
DR PRIDE; Q9LV52; -.
DR ProteomicsDB; 232133; -.
DR EnsemblPlants; AT3G24520.1; AT3G24520.1; AT3G24520.
DR GeneID; 822047; -.
DR Gramene; AT3G24520.1; AT3G24520.1; AT3G24520.
DR KEGG; ath:AT3G24520; -.
DR Araport; AT3G24520; -.
DR TAIR; locus:2091762; AT3G24520.
DR eggNOG; KOG0627; Eukaryota.
DR HOGENOM; CLU_875490_0_0_1; -.
DR InParanoid; Q9LV52; -.
DR OMA; KHARGMY; -.
DR OrthoDB; 1154048at2759; -.
DR PhylomeDB; Q9LV52; -.
DR PRO; PR:Q9LV52; -.
DR Proteomes; UP000006548; Chromosome 3.
DR ExpressionAtlas; Q9LV52; baseline and differential.
DR Genevisible; Q9LV52; AT.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:TAIR.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0034605; P:cellular response to heat; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR Gene3D; 1.10.10.10; -; 1.
DR InterPro; IPR000232; HSF_DNA-bd.
DR InterPro; IPR027725; HSF_fam.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR10015; PTHR10015; 1.
DR Pfam; PF00447; HSF_DNA-bind; 1.
DR PRINTS; PR00056; HSFDOMAIN.
DR SMART; SM00415; HSF; 1.
DR SUPFAM; SSF46785; SSF46785; 1.
DR PROSITE; PS00434; HSF_DOMAIN; 1.
PE 1: Evidence at protein level;
KW DNA-binding; Nucleus; Phosphoprotein; Reference proteome; Stress response;
KW Transcription; Transcription regulation.
FT CHAIN 1..330
FT /note="Heat stress transcription factor C-1"
FT /id="PRO_0000270814"
FT DNA_BIND 15..109
FT /evidence="ECO:0000250"
FT REGION 114..166
FT /note="Hydrophobic repeat HR-A/B"
FT REGION 180..235
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 268..291
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 191..195
FT /note="Nuclear localization signal"
FT /evidence="ECO:0000255"
FT COMPBIAS 180..203
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 218..235
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 268..283
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 330 AA; 37714 MW; 8F534D8D19E6F5B0 CRC64;
MEDDNSNNNN NNNVIAPFIV KTYQMVNDPS TDWLITWGPA HNSFIVVDPL DFSQRILPAY
FKHNNFSSFV RQLNTYGFRK VDPDRWEFAN EHFLRGQKHL LNNIARRKHA RGMYGQDLED
GEIVREIERL KEEQRELEAE IQRMNRRIEA TEKRPEQMMA FLYKVVEDPD LLPRMMLEKE
RTKQQQQVSD KKKRRVTMST VKSEEEEVEE DEGRVFRVMS SSTPSPSSTE NLYRNHSPDG
WIVPMTQGQF GSYETGLVAK SMLSNSTSST SSSLTSTFSL PESVNGGGGG GCGSIQGERR
YKETATFGGV VESNPPTTPP YPFSLFRGGF
