ID   HSF_ENCCU               Reviewed;         244 AA.
AC   Q8SS62;
DT   03-NOV-2009, integrated into UniProtKB/Swiss-Prot.
DT   29-MAY-2013, sequence version 2.
DT   25-MAY-2022, entry version 99.
DE   RecName: Full=Heat shock transcription factor {ECO:0000312|EMBL:CAD25227.2};
DE            Short=HSTF {ECO:0000305};
DE   AltName: Full=Heat shock factor protein {ECO:0000305};
DE            Short=HSF {ECO:0000305};
GN   Name=HSF {ECO:0000305};
GN   OrderedLocusNames=ECU04_0400 {ECO:0000312|EMBL:CAD25227.2};
OS   Encephalitozoon cuniculi (strain GB-M1) (Microsporidian parasite).
OC   Eukaryota; Fungi; Fungi incertae sedis; Microsporidia; Unikaryonidae;
OC   Encephalitozoon.
OX   NCBI_TaxID=284813;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=GB-M1;
RX   PubMed=11719806; DOI=10.1038/35106579;
RA   Katinka M.D., Duprat S., Cornillot E., Metenier G., Thomarat F.,
RA   Prensier G., Barbe V., Peyretaillade E., Brottier P., Wincker P.,
RA   Delbac F., El Alaoui H., Peyret P., Saurin W., Gouy M., Weissenbach J.,
RA   Vivares C.P.;
RT   "Genome sequence and gene compaction of the eukaryote parasite
RT   Encephalitozoon cuniculi.";
RL   Nature 414:450-453(2001).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=GB-M1;
RX   PubMed=20003517; DOI=10.1186/1471-2164-10-607;
RA   Peyretaillade E., Goncalves O., Terrat S., Dugat-Bony E., Wincker P.,
RA   Cornman R.S., Evans J.D., Delbac F., Peyret P.;
RT   "Identification of transcriptional signals in Encephalitozoon cuniculi
RT   widespread among Microsporidia phylum: support for accurate structural
RT   genome annotation.";
RL   BMC Genomics 10:607-607(2009).
CC   -!- FUNCTION: DNA-binding transcription factor that specifically binds heat
CC       shock promoter elements (HSE) and activates transcription.
CC       {ECO:0000250|UniProtKB:P10961}.
CC   -!- SUBUNIT: Homotrimer (By similarity). Homotrimerization increases the
CC       affinity of HSF1 to DNA (By similarity).
CC       {ECO:0000250|UniProtKB:P10961}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P10961}.
CC   -!- SIMILARITY: Belongs to the HSF family. {ECO:0000305}.
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DR   EMBL; AL590444; CAD25227.2; -; Genomic_DNA.
DR   RefSeq; NP_584723.1; NM_001041073.1.
DR   AlphaFoldDB; Q8SS62; -.
DR   SMR; Q8SS62; -.
DR   STRING; 284813.Q8SS62; -.
DR   GeneID; 858871; -.
DR   KEGG; ecu:ECU04_0400; -.
DR   VEuPathDB; MicrosporidiaDB:ECU04_0400; -.
DR   HOGENOM; CLU_030308_8_1_1; -.
DR   InParanoid; Q8SS62; -.
DR   OrthoDB; 1154048at2759; -.
DR   Proteomes; UP000000819; Chromosome IV.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR000232; HSF_DNA-bd.
DR   InterPro; IPR027725; HSF_fam.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR10015; PTHR10015; 1.
DR   Pfam; PF00447; HSF_DNA-bind; 1.
DR   SMART; SM00415; HSF; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
PE   3: Inferred from homology;
KW   Activator; DNA-binding; Nucleus; Reference proteome; Stress response;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..244
FT                   /note="Heat shock transcription factor"
FT                   /id="PRO_0000388428"
FT   DNA_BIND        13..108
FT                   /evidence="ECO:0000250|UniProtKB:P10961"
FT   REGION          123..168
FT                   /note="Involved in trimerization"
FT                   /evidence="ECO:0000250|UniProtKB:P22121"
FT   REGION          204..244
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        230..244
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   244 AA;  28315 MW;  C65B6C127A7A87DB CRC64;
     MERSSTSFNF DKIPKFIMKL YKATNNEKYK GICWTPDGLK IHIYDRDVFV KETLPLISKT
     REFGTFVRML NSYGFVKSKD IEEEDIYYNK NFRKGREDLL GFDDSLRMIK RKKSSDIRMR
     IGDGSLKEIV EYLYVQNQEL YTELSVCKER IERQERALNG LIEILSRVFR TNSQDLGARI
     KPSGHNPHNE MDFFLGELSG PLKEGCEPAS PPLQDKGIPE LSFKPGGIPH ADSDTKDDNY
     DPFF