ID   HSF_ENTBH               Reviewed;         245 AA.
AC   B7XIV9;
DT   03-NOV-2009, integrated into UniProtKB/Swiss-Prot.
DT   03-MAR-2009, sequence version 1.
DT   25-MAY-2022, entry version 54.
DE   RecName: Full=Heat shock transcription factor {ECO:0000312|EMBL:EED44099.1};
DE            Short=HSTF {ECO:0000305};
DE   AltName: Full=Heat shock factor protein {ECO:0000305};
DE            Short=HSF {ECO:0000305};
GN   Name=HSF {ECO:0000305}; ORFNames=EBI_23973 {ECO:0000312|EMBL:EED44099.1};
OS   Enterocytozoon bieneusi (strain H348) (Microsporidian parasite).
OC   Eukaryota; Fungi; Fungi incertae sedis; Microsporidia; Enterocytozoonidae;
OC   Enterocytozoon.
OX   NCBI_TaxID=481877;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=H348;
RX   PubMed=18060071; DOI=10.1371/journal.pone.0001277;
RA   Corradi N., Akiyoshi D.E., Morrison H.G., Feng X., Weiss L.M., Tzipori S.,
RA   Keeling P.J.;
RT   "Patterns of genome evolution among the microsporidian parasites
RT   Encephalitozoon cuniculi, Antonospora locustae and Enterocytozoon
RT   bieneusi.";
RL   PLoS ONE 2:E1277-E1277(2007).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=H348;
RX   PubMed=19132089; DOI=10.1371/journal.ppat.1000261;
RA   Akiyoshi D.E., Morrison H.G., Lei S., Feng X., Zhang Q., Corradi N.,
RA   Mayanja H., Tumwine J.K., Keeling P.J., Weiss L.M., Tzipori S.;
RT   "Genomic survey of the non-cultivatable opportunistic human pathogen,
RT   Enterocytozoon bieneusi.";
RL   PLoS Pathog. 5:E1000261-E1000261(2009).
CC   -!- FUNCTION: DNA-binding transcription factor that specifically binds heat
CC       shock promoter elements (HSE) and activates transcription.
CC       {ECO:0000250|UniProtKB:P10961}.
CC   -!- SUBUNIT: Homotrimer (By similarity). Homotrimerization increases the
CC       affinity of HSF1 to DNA (By similarity).
CC       {ECO:0000250|UniProtKB:P10961}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P10961}.
CC   -!- SIMILARITY: Belongs to the HSF family. {ECO:0000305}.
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DR   EMBL; ABGB01000022; EED44099.1; -; Genomic_DNA.
DR   RefSeq; XP_002649937.1; XM_002649891.1.
DR   AlphaFoldDB; B7XIV9; -.
DR   SMR; B7XIV9; -.
DR   STRING; 481877.B7XIV9; -.
DR   PRIDE; B7XIV9; -.
DR   EnsemblFungi; EED44099; EED44099; EBI_23973.
DR   VEuPathDB; MicrosporidiaDB:EBI_23973; -.
DR   HOGENOM; CLU_030308_8_1_1; -.
DR   InParanoid; B7XIV9; -.
DR   Proteomes; UP000001742; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR000232; HSF_DNA-bd.
DR   InterPro; IPR027725; HSF_fam.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR10015; PTHR10015; 1.
DR   Pfam; PF00447; HSF_DNA-bind; 1.
DR   SMART; SM00415; HSF; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
PE   3: Inferred from homology;
KW   Activator; DNA-binding; Nucleus; Reference proteome; Stress response;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..245
FT                   /note="Heat shock transcription factor"
FT                   /id="PRO_0000388429"
FT   DNA_BIND        17..115
FT                   /evidence="ECO:0000250|UniProtKB:P10961"
FT   REGION          130..169
FT                   /note="Involved in trimerization"
FT                   /evidence="ECO:0000250|UniProtKB:P22121"
SQ   SEQUENCE   245 AA;  29030 MW;  BFBD627BA6EFBED9 CRC64;
     MAKRKEVTEI SEMDIKKSGF VNRLYRETCD ISNKYIKFDD DGDKLIIPNK IDFIKKALNK
     ISSTKDYSSF VRQLNNYGFT KIKLDNGDSN CDIYYHQNFH RDHPDLISLI TRDKSKNGDY
     KDNMTTFINS LQYLASCNYK QQKEINDLKD RIKTLETKYA TLYEIISNAF RQGIEQYQKH
     NTMYFNNNSL LKNMFTYNQE LDDLKDNTNV YNNAKLINQL KLDAKNSNQD DNIKKTKNAF
     DEFYF