ID   HSF_NOSCE               Reviewed;         243 AA.
AC   C4V6H6;
DT   03-NOV-2009, integrated into UniProtKB/Swiss-Prot.
DT   28-JUL-2009, sequence version 1.
DT   25-MAY-2022, entry version 52.
DE   RecName: Full=Probable heat shock transcription factor {ECO:0000305};
DE            Short=HSTF {ECO:0000305};
DE   AltName: Full=Heat shock factor protein {ECO:0000305};
DE            Short=HSF {ECO:0000305};
GN   Name=HSF {ECO:0000305}; ORFNames=NCER_100004 {ECO:0000312|EMBL:EEQ83147.1};
OS   Nosema ceranae (strain BRL01) (Microsporidian parasite).
OC   Eukaryota; Fungi; Fungi incertae sedis; Microsporidia; Nosematidae; Nosema.
OX   NCBI_TaxID=578460;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=BRL01;
RX   PubMed=19503607; DOI=10.1371/journal.ppat.1000466;
RA   Cornman R.S., Chen Y.P., Schatz M.C., Street C., Zhao Y., Desany B.,
RA   Egholm M., Hutchison S., Pettis J.S., Lipkin W.I., Evans J.D.;
RT   "Genomic analyses of the microsporidian Nosema ceranae, an emergent
RT   pathogen of honey bees.";
RL   PLoS Pathog. 5:E1000466-E1000466(2009).
CC   -!- FUNCTION: DNA-binding transcription factor that specifically binds heat
CC       shock promoter elements (HSE) and activates transcription.
CC       {ECO:0000250|UniProtKB:P10961}.
CC   -!- SUBUNIT: Homotrimer (By similarity). Homotrimerization increases the
CC       affinity of HSF1 to DNA (By similarity).
CC       {ECO:0000250|UniProtKB:P10961}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P10961}.
CC   -!- SIMILARITY: Belongs to the HSF family. {ECO:0000305}.
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DR   EMBL; ACOL01000001; EEQ83147.1; -; Genomic_DNA.
DR   RefSeq; XP_002996818.1; XM_002996772.1.
DR   AlphaFoldDB; C4V6H6; -.
DR   SMR; C4V6H6; -.
DR   STRING; 578460.C4V6H6; -.
DR   EnsemblFungi; EEQ83147; EEQ83147; NCER_100004.
DR   KEGG; nce:NCER_100004; -.
DR   VEuPathDB; MicrosporidiaDB:NCER_100004; -.
DR   HOGENOM; CLU_030308_8_1_1; -.
DR   InParanoid; C4V6H6; -.
DR   OMA; STSESHW; -.
DR   Proteomes; UP000009082; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR000232; HSF_DNA-bd.
DR   InterPro; IPR027725; HSF_fam.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR10015; PTHR10015; 1.
DR   Pfam; PF00447; HSF_DNA-bind; 1.
DR   SMART; SM00415; HSF; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
PE   3: Inferred from homology;
KW   Activator; DNA-binding; Nucleus; Reference proteome; Stress response;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..243
FT                   /note="Probable heat shock transcription factor"
FT                   /id="PRO_0000388430"
FT   DNA_BIND        9..102
FT                   /evidence="ECO:0000255"
FT   REGION          121..164
FT                   /note="Involved in trimerization"
FT                   /evidence="ECO:0000250|UniProtKB:P22121"
SQ   SEQUENCE   243 AA;  28581 MW;  024A46B5CBD4294C CRC64;
     MKSDKTPKIN KFIRRLYKIV NDNSFSEIQW TTDGLRFYIT DKTAFMLNGL KYLSKTTEYS
     AFVRLLYVYG FSKSKSLNAY EEEYYHKNFK RDGDNLLPCI QRTVETKTTL LQKNTNRTPN
     QLQDLLQYLN NQNFKLEGEI KSLKDRVDQQ DCTINGLVQL LTRIFRTNDS NKDMLLPLNI
     TEHGSPINNE LRINYDKNQV ARLMADTPNI DGRLENTNIE LSNNKNFLFD SDDEDSIYKT
     NFF