ID   HSF_XENLA               Reviewed;         451 AA.
AC   P41154;
DT   01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1995, sequence version 1.
DT   25-MAY-2022, entry version 107.
DE   RecName: Full=Heat shock factor protein;
DE            Short=HSF;
DE   AltName: Full=Heat shock transcription factor;
DE            Short=HSTF;
GN   Name=hsf1; Synonyms=hsf;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=7642097; DOI=10.1016/0378-1119(95)00176-7;
RA   Stump D.G., Landsberger N., Wolffe A.P.;
RT   "The cDNA encoding Xenopus laevis heat-shock factor 1 (XHSF1): nucleotide
RT   and deduced amino-acid sequences, and properties of the encoded protein.";
RL   Gene 160:207-211(1995).
CC   -!- FUNCTION: DNA-binding protein that specifically binds heat shock
CC       promoter elements (HSE) and activates transcription. {ECO:0000250}.
CC   -!- SUBUNIT: Homotrimer.
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- PTM: Exhibits temperature-dependent phosphorylation. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the HSF family. {ECO:0000305}.
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DR   EMBL; L36924; AAA99999.1; -; mRNA.
DR   PIR; JC4199; JC4199.
DR   RefSeq; NP_001084036.1; NM_001090567.1.
DR   AlphaFoldDB; P41154; -.
DR   SMR; P41154; -.
DR   GeneID; 399268; -.
DR   CTD; 3297; -.
DR   Proteomes; UP000186698; Genome assembly.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR000232; HSF_DNA-bd.
DR   InterPro; IPR027725; HSF_fam.
DR   InterPro; IPR010542; Vert_HSTF_C.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR10015; PTHR10015; 1.
DR   Pfam; PF00447; HSF_DNA-bind; 1.
DR   Pfam; PF06546; Vert_HS_TF; 1.
DR   PRINTS; PR00056; HSFDOMAIN.
DR   SMART; SM00415; HSF; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   PROSITE; PS00434; HSF_DOMAIN; 1.
PE   2: Evidence at transcript level;
KW   Activator; DNA-binding; Nucleus; Phosphoprotein; Reference proteome;
KW   Stress response; Transcription; Transcription regulation.
FT   CHAIN           1..451
FT                   /note="Heat shock factor protein"
FT                   /id="PRO_0000124577"
FT   DNA_BIND        12..117
FT                   /evidence="ECO:0000250"
FT   REGION          210..273
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          285..307
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        211..260
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   451 AA;  49473 MW;  3E271549BBCABB10 CRC64;
     MDPHGTCGGS NVPAFLAKLW TLVEDPDTDP LICWSPEGNS FHVFDQGQFA KEVLPKYFKH
     NNMASFVRQL NMYGFRKVVH IEQGGLVKPE RDDTEFQHPY FIRGQEQLLE NIKRKVNTMS
     ATKSDEVKVR QDSVGKLISD VQSMKGKQES IDGRLLSMKH ENEALWREVA SLRQKHTQQQ
     KVVNKLIQFL VSLVQSNRIL GVKRKIPLML NDSSTGHSPP KYSRQYSLEH VPSSTSYPVS
     GFTDSSAGPI ISDVTELPES SPSPSPCPSL EASPSPVILI KTEPLTPSQS PEQSPAPPKL
     DDTPISPSTF IDSILLETET SVCPGGNKND EMSESHPPEP CLSVACLDNI SLSRQMSEVS
     RLFPTSCSSV PGRAEPPGLD MAVAELNDHV DNIDFNLDTL QNLLNGQSFS VDTSALMDLF
     SPSLGIPDLS LPDPDSSLAS VSSTPIYTCV V