ID   HSH2D_DANRE             Reviewed;         365 AA.
AC   Q56A36;
DT   02-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT   10-MAY-2005, sequence version 1.
DT   03-AUG-2022, entry version 70.
DE   RecName: Full=Hematopoietic SH2 domain-containing protein homolog;
GN   Name=hsh2d;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=AB; TISSUE=Embryo;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May be an adapter protein involved in tyrosine kinase
CC       signaling. {ECO:0000250}.
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DR   EMBL; BC092186; AAH92186.1; -; mRNA.
DR   AlphaFoldDB; Q56A36; -.
DR   SMR; Q56A36; -.
DR   STRING; 7955.ENSDARP00000062985; -.
DR   PaxDb; Q56A36; -.
DR   ZFIN; ZDB-GENE-050410-3; hsh2d.
DR   eggNOG; ENOG502RZYN; Eukaryota.
DR   InParanoid; Q56A36; -.
DR   PhylomeDB; Q56A36; -.
DR   PRO; PR:Q56A36; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   Gene3D; 3.30.505.10; -; 1.
DR   InterPro; IPR035047; HSH2D.
DR   InterPro; IPR000980; SH2.
DR   InterPro; IPR036860; SH2_dom_sf.
DR   PANTHER; PTHR14388:SF3; PTHR14388:SF3; 1.
DR   Pfam; PF00017; SH2; 1.
DR   PRINTS; PR00401; SH2DOMAIN.
DR   SMART; SM00252; SH2; 1.
DR   SUPFAM; SSF55550; SSF55550; 1.
DR   PROSITE; PS50001; SH2; 1.
PE   2: Evidence at transcript level;
KW   Reference proteome; SH2 domain.
FT   CHAIN           1..365
FT                   /note="Hematopoietic SH2 domain-containing protein homolog"
FT                   /id="PRO_0000233131"
FT   DOMAIN          34..125
FT                   /note="SH2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00191"
FT   REGION          199..278
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          335..365
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        256..278
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   365 AA;  41320 MW;  5B911FCBCF32F8FE CRC64;
     MAVPLPNDSS NAAFSWFTEY QRSCILENGV VPEWFHGIIS RKAAEEMLMC KPAGYFLIRV
     SESRVGYTLS YRAEDRCRHF MINVLPDNQF MIVGEKTVYC SLHDLVAFHR RCPILPYNEL
     LTVACEQGGK TNYVELLFPQ KKDVSHRQVE WISSSTATNT LQSNISEENQ TSQLQNNSTS
     HPGRLYPSLE TEVSALNIQS TDQPTKPVPK PRTVFASKTP AEETPPQLPP RMRLPSRLQT
     STEDRSQGLM PVIPDRQQIT PNTPNEGRTQ QKNQQQKPVV MSLVHIKKKL KKKRSEDHTY
     EEIAGGLFQK DATSALESIN TNVEGLVEND YQELAEHPIS DGIPKSSDRN LPVEYRHPPP
     FAPGY