ID   HSL27_DICDI             Reviewed;          97 AA.
AC   P15649; Q553J8; Q86H90;
DT   01-APR-1990, integrated into UniProtKB/Swiss-Prot.
DT   06-MAR-2007, sequence version 2.
DT   25-MAY-2022, entry version 85.
DE   RecName: Full=HssA/B-like protein 27;
DE   AltName: Full=Protein 7E;
GN   Name=hssl27; Synonyms=7E; ORFNames=DDB_G0275437;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=AX2;
RX   PubMed=2157129; DOI=10.1111/j.1365-2958.1990.tb02022.x;
RA   Ramji D.P., Richards A.J., Jagger P., Bleasby A., Hames B.D.;
RT   "Two cyclic AMP-regulated genes from Dictyostelium discoideum encode
RT   homologous proteins.";
RL   Mol. Microbiol. 4:129-135(1990).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=12097910; DOI=10.1038/nature00847;
RA   Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T.,
RA   Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R.,
RA   Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A.,
RA   Noegel A.A.;
RT   "Sequence and analysis of chromosome 2 of Dictyostelium discoideum.";
RL   Nature 418:79-85(2002).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
RN   [4]
RP   DEVELOPMENTAL STAGE, AND INDUCTION.
RX   PubMed=2161991; DOI=10.1111/j.1365-2958.1990.tb00630.x;
RA   Corney A.J., Richards A.J., Phillpots T., Hames B.D.;
RT   "Developmental regulation of cell-type-enriched mRNAs in Dictyostelium
RT   discoideum.";
RL   Mol. Microbiol. 4:613-623(1990).
RN   [5]
RP   DEVELOPMENTAL STAGE, AND INDUCTION.
RX   PubMed=2177818; DOI=10.1111/j.1365-2958.1990.tb00707.x;
RA   Richards A.J., Corney A.J., Hames B.D.;
RT   "Cell-type-specific genes expressed late in Dictyostelium development show
RT   markedly different responses to 3'5' cyclic AMP.";
RL   Mol. Microbiol. 4:1279-1291(1990).
CC   -!- DEVELOPMENTAL STAGE: Expressed in the prestalk cells and prespore
CC       cells. Expressed only late in development. First detected in finger
CC       stage and expression levels peak in late culmination (18-22 hours). Its
CC       expression ceases upon cell disaggregation but is fully restored by
CC       exogenous cAMP. {ECO:0000269|PubMed:2161991,
CC       ECO:0000269|PubMed:2177818}.
CC   -!- INDUCTION: By exogenous cAMP. {ECO:0000269|PubMed:2161991,
CC       ECO:0000269|PubMed:2177818}.
CC   -!- SIMILARITY: Belongs to the hssA/B family. {ECO:0000305}.
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DR   EMBL; X16959; CAA34832.1; -; mRNA.
DR   EMBL; AAFI02000013; EAL69469.1; -; Genomic_DNA.
DR   PIR; S08136; S08136.
DR   RefSeq; XP_643415.1; XM_638323.1.
DR   AlphaFoldDB; P15649; -.
DR   STRING; 44689.DDB0219940; -.
DR   PaxDb; P15649; -.
DR   EnsemblProtists; EAL69469; EAL69469; DDB_G0275437.
DR   GeneID; 8620001; -.
DR   KEGG; ddi:DDB_G0275437; -.
DR   dictyBase; DDB_G0275437; 7E.
DR   HOGENOM; CLU_2404148_0_0_1; -.
DR   PRO; PR:P15649; -.
DR   Proteomes; UP000002195; Chromosome 2.
DR   GO; GO:0031154; P:culmination involved in sorocarp development; IEP:UniProtKB.
DR   GO; GO:0031153; P:slug development involved in sorocarp development; IEP:UniProtKB.
DR   GO; GO:0030587; P:sorocarp development; IGI:dictyBase.
DR   InterPro; IPR008455; HssA/B-related.
DR   Pfam; PF05710; Coiled; 1.
PE   2: Evidence at transcript level;
KW   Reference proteome.
FT   CHAIN           1..97
FT                   /note="HssA/B-like protein 27"
FT                   /id="PRO_0000064400"
FT   CONFLICT        97
FT                   /note="N -> I (in Ref. 1; CAA34832)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   97 AA;  9111 MW;  E7D20C259858B830 CRC64;
     MTILASICKL GNTKSTSSSI GSSYSSAVSF GSNSVSCGEC GGDGPSFPNA SPRTGVKAGV
     NVDGLLGAIG KTVNGMLISP NGGGGGMGMG GGSCGCN