3SX3_MICMP
ID 3SX3_MICMP Reviewed; 79 AA.
AC A0A2P1BSU3;
DT 12-AUG-2020, integrated into UniProtKB/Swiss-Prot.
DT 23-MAY-2018, sequence version 1.
DT 25-MAY-2022, entry version 9.
DE RecName: Full=Mipartoxin-3 {ECO:0000303|PubMed:31557485};
DE AltName: Full=Mipartoxin-III {ECO:0000312|EMBL:AVI57322.1};
DE AltName: Full=Three-finger toxin-04 {ECO:0000303|PubMed:31557485};
DE Short=3FTx-04 {ECO:0000303|PubMed:31557485};
DE Flags: Precursor;
OS Micrurus mipartitus (Red-tailed coral snake).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Serpentes; Colubroidea; Elapidae; Elapinae; Micrurus.
OX NCBI_TaxID=430902 {ECO:0000312|EMBL:AVI57322.1};
RN [1] {ECO:0000305}
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC TISSUE=Venom gland {ECO:0000303|PubMed:31557485};
RX PubMed=31557485; DOI=10.1016/j.toxicon.2019.09.017;
RA Rey-Suarez P., Saldarriaga-Cordoba M., Torres U., Marin-Villa M.,
RA Lomonte B., Nunez V.;
RT "Novel three-finger toxins from Micrurus dumerilii and Micrurus mipartitus
RT coral snake venoms: Phylogenetic relationships and characterization of
RT Clarkitoxin-I-Mdum.";
RL Toxicon 170:85-93(2019).
CC -!- FUNCTION: Snake venom neurotoxin that blocks neuromuscular
CC transmission, presenting a postsynaptic action through the nicotinic
CC acetylcholine receptor (nAChR). Has no cytotoxic activity.
CC {ECO:0000250|UniProtKB:B3EWF8}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:B3EWF8}.
CC -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC {ECO:0000269|PubMed:31557485}.
CC -!- SIMILARITY: Belongs to the snake three-finger toxin family. Short-chain
CC subfamily. {ECO:0000305}.
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DR EMBL; KY635903; AVI57322.1; -; mRNA.
DR AlphaFoldDB; A0A2P1BSU3; -.
DR SMR; A0A2P1BSU3; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0030550; F:acetylcholine receptor inhibitor activity; IEA:UniProtKB-KW.
DR GO; GO:0099106; F:ion channel regulator activity; IEA:UniProtKB-KW.
DR GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR Gene3D; 2.10.60.10; -; 1.
DR InterPro; IPR016054; LY6_UPA_recep-like.
DR InterPro; IPR045860; Snake_toxin-like_sf.
DR Pfam; PF00021; UPAR_LY6; 1.
DR SUPFAM; SSF57302; SSF57302; 1.
PE 2: Evidence at transcript level;
KW Acetylcholine receptor inhibiting toxin; Disulfide bond;
KW Ion channel impairing toxin; Neurotoxin; Postsynaptic neurotoxin; Secreted;
KW Signal; Toxin.
FT SIGNAL 1..21
FT /evidence="ECO:0000255"
FT CHAIN 22..79
FT /note="Mipartoxin-3"
FT /evidence="ECO:0000255"
FT /id="PRO_5015126796"
FT DISULFID 24..41
FT /evidence="ECO:0000250|UniProtKB:P07526"
FT DISULFID 34..59
FT /evidence="ECO:0000250|UniProtKB:P07526"
FT DISULFID 63..71
FT /evidence="ECO:0000250|UniProtKB:P07526"
FT DISULFID 72..77
FT /evidence="ECO:0000250|UniProtKB:P07526"
SQ SEQUENCE 79 AA; 8600 MW; A154C5295E287F2F CRC64;
MKTLLLTLVV VTIVCLDLGN SLKCYDKLKK EVTCPEGMKF CHKDVLPATH GNSVLVMGCT
YSCGLGPRNM CCSTDLCNK
