AP3B_DICDI
ID AP3B_DICDI Reviewed; 1108 AA.
AC Q556J8; Q86AM8;
DT 08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 02-MAY-2006, sequence version 1.
DT 25-MAY-2022, entry version 98.
DE RecName: Full=AP-3 complex subunit beta;
DE AltName: Full=Adaptor protein complex AP-3 beta subunit;
DE AltName: Full=Adaptor-related protein complex 3 subunit beta;
DE AltName: Full=Beta-3-adaptin;
DE AltName: Full=Clathrin assembly protein complex 3 beta large chain;
GN Name=ap3b-1; ORFNames=DDB_G0272578;
GN and
GN Name=ap3b-2; ORFNames=DDB_G0274003;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=12097910; DOI=10.1038/nature00847;
RA Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T.,
RA Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R.,
RA Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A.,
RA Noegel A.A.;
RT "Sequence and analysis of chromosome 2 of Dictyostelium discoideum.";
RL Nature 418:79-85(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- FUNCTION: Part of the AP-3 complex, an adaptor-related complex which is
CC essential for the compartmentalization of the endocytic pathway.
CC -!- SUBUNIT: Adaptor protein complex 3 (AP-3) is a heterotetramer composed
CC of two large adaptins (delta-type subunit and beta-type subunit), a
CC medium adaptin (mu-type subunit) and a small adaptin (sigma-type
CC subunit). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Endosome membrane {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the adaptor complexes large subunit family.
CC {ECO:0000305}.
CC -!- CAUTION: The gene for this protein is duplicated in strains AX3 and
CC AX4. These strains contain a duplication of a segment of 750 kb of
CC chromosome 2 compared to the corresponding sequence in strain AX2.
CC {ECO:0000305}.
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DR EMBL; AAFI02000011; EAL70435.1; -; Genomic_DNA.
DR EMBL; AAFI02000009; EAL70926.1; -; Genomic_DNA.
DR RefSeq; XP_644360.1; XM_639268.1.
DR RefSeq; XP_645054.1; XM_639962.1.
DR AlphaFoldDB; Q556J8; -.
DR SMR; Q556J8; -.
DR STRING; 44689.DDB0237724; -.
DR PaxDb; Q556J8; -.
DR EnsemblProtists; EAL70435; EAL70435; DDB_G0274003.
DR EnsemblProtists; EAL70926; EAL70926; DDB_G0272578.
DR GeneID; 8618729; -.
DR GeneID; 8619247; -.
DR KEGG; ddi:DDB_G0272578; -.
DR KEGG; ddi:DDB_G0274003; -.
DR dictyBase; DDB_G0272578; ap3b-1.
DR dictyBase; DDB_G0274003; ap3b-2.
DR eggNOG; KOG1060; Eukaryota.
DR HOGENOM; CLU_006320_3_1_1; -.
DR InParanoid; Q556J8; -.
DR OMA; IGRCAQS; -.
DR PhylomeDB; Q556J8; -.
DR PRO; PR:Q556J8; -.
DR Proteomes; UP000002195; Chromosome 2.
DR GO; GO:0030123; C:AP-3 adaptor complex; IDA:dictyBase.
DR GO; GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR GO; GO:0016192; P:vesicle-mediated transport; IBA:GO_Central.
DR Gene3D; 1.25.10.10; -; 1.
DR InterPro; IPR026740; AP3_beta.
DR InterPro; IPR029390; AP3B_C.
DR InterPro; IPR026739; AP_beta.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR002553; Clathrin/coatomer_adapt-like_N.
DR PANTHER; PTHR11134; PTHR11134; 1.
DR PANTHER; PTHR11134:SF1; PTHR11134:SF1; 1.
DR Pfam; PF01602; Adaptin_N; 2.
DR Pfam; PF14796; AP3B1_C; 1.
DR PIRSF; PIRSF037096; AP3_complex_beta; 1.
DR SMART; SM01355; AP3B1_C; 1.
DR SUPFAM; SSF48371; SSF48371; 1.
PE 3: Inferred from homology;
KW Endosome; Membrane; Protein transport; Reference proteome; Repeat;
KW Transport.
FT CHAIN 1..1108
FT /note="AP-3 complex subunit beta"
FT /id="PRO_0000328677"
FT REPEAT 90..127
FT /note="HEAT 1"
FT REPEAT 327..363
FT /note="HEAT 2"
FT REPEAT 397..433
FT /note="HEAT 3"
FT REPEAT 434..471
FT /note="HEAT 4"
FT REGION 480..501
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 736..797
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 811..835
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 736..761
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 762..783
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1108 AA; 126899 MW; 4A5EED095DE387D8 CRC64;
MDTVLNNINQ SRYFNDSTAN TKIEEIKKHL DSPSDADKLE SMKKLIAMLS KGRDVSEAFP
QVVKNVIVKN LEIKKLVYMY LVHYAESQND SALLSINTIQ KSLNDQSQVI RASALRVMSS
IRVIDIIEVI ILAIEKSVKD TSPFVRKAAA FAIAKVHKLD CDKQEPLIDL LEILLNDTST
MVLGAAIVAF NELCPQRFDL LHQHYRKICQ LLADFDEWSQ VIVLDILTKY ARSQFRCPDS
TMNDKNIKQF KKKSKSFYSD EEDQEDDEPE NSLYKKKPLE RDMFDSSEEI DMDHRLLLKS
TLPLLQSRNN AVVMAVSSLY FYCAPSIEAQ KVGKSLVRIL RSGPEVQYIT LTNISTMVTL
RPSMFEPHLS EFFIHSSDPE YSIKLKLEIL TRLATPENIG KILKEFKEYV KNEDKKFVAA
TIQAIGSCAS TVPDVTESCI YGLMSLLSNQ STVVVAESVI VLKRLLQLNA TNEKLEKLEK
EKEKEKDVKE NQSTISKHSS SNNSIKYDNI ILHLSKLLDT LQVPSARASI VWVIGEYCYR
VPLVAPDVFR KLVKSFSDEH ESVKLETLNL GSKLYVQFTD NNSTTTTDNS IPNEFKNERT
KEKITLMFQY VLNLAKFDQN YDIRDNSRML KHFYFNTENT QSINSNIKQI VINQKPIPTE
TSISEDRQRF TLGSLSHIVN HTALGYTALP DFPDVAPDPS VREPIQRWIP NQQSQQQQHQ
QQQLNNIFVD TPFYSDEEEE DEEEYDEEEE EEEYEEQNEY EDFFGEEKKN KKKNRKQQNY
DEDEYNQDID DGEYDGEGEV QAEDEDDFDE LFGITNDDNN QTANGIGGGG SGEEEMDKFD
FENYINSTTK SVKKILLKPT ISGGLSIDYC FIRIRDNEEF SCQPRYNIIQ LNIKNQSDET
FTDISIINKN LIDGADISEF DPIESIEPNQ AIQKQIYVLF NSTSQSCKFE ISFNKGNFPV
TLTPIIGELL IPIVPIYESI SQWKDEFEEV GEFKQVDDQF EFGDQCLDKL NNNNNNNNNN
NNESGDENIG LMPILPIVLE GINLIPIASN KLKSKIQFAS KTLLKDENIY VQIQLLKQQP
PTVNCIIRSN DQVVSALLLK KLKDVLQK
