ID   3SX3_MICNI              Reviewed;          28 AA.
AC   Q9PRQ3;
DT   03-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT   03-MAY-2011, sequence version 2.
DT   25-MAY-2022, entry version 45.
DE   RecName: Full=Nicotinic acetylcholine receptor-binding protein Mnn-3C {ECO:0000303|PubMed:8603741};
DE   AltName: Full=Three-finger toxin;
DE            Short=3FTx;
DE   Flags: Fragment;
OS   Micrurus nigrocinctus (Central American coral snake) (Gargantilla).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC   Serpentes; Colubroidea; Elapidae; Elapinae; Micrurus.
OX   NCBI_TaxID=8635;
RN   [1]
RP   PROTEIN SEQUENCE, FUNCTION, AND SUBCELLULAR LOCATION.
RC   TISSUE=Venom;
RX   PubMed=8603741; DOI=10.1016/0014-5793(95)01543-4;
RA   Alape-Giron A., Persson B., Cedelund E., Flores-Diaz M., Gutierrez J.-M.,
RA   Thelestam M., Bergman T., Joernvall H.;
RT   "Characterization of multiple nicotinic acetylcholine receptor-binding
RT   proteins and phospholipases A2 from the venom of the coral snake Micrurus
RT   nigrocinctus.";
RL   FEBS Lett. 380:29-32(1996).
CC   -!- FUNCTION: Binds and may inhibit nicotinic acetylcholine receptors
CC       (nAChR). {ECO:0000269|PubMed:8603741}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:8603741}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the snake three-finger toxin family. Short-chain
CC       subfamily. {ECO:0000305}.
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DR   PIR; S68643; S68643.
DR   AlphaFoldDB; Q9PRQ3; -.
DR   SMR; Q9PRQ3; -.
DR   PRIDE; Q9PRQ3; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0030550; F:acetylcholine receptor inhibitor activity; IEA:UniProtKB-KW.
DR   GO; GO:0099106; F:ion channel regulator activity; IEA:UniProtKB-KW.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   Gene3D; 2.10.60.10; -; 1.
DR   InterPro; IPR045860; Snake_toxin-like_sf.
DR   SUPFAM; SSF57302; SSF57302; 1.
PE   1: Evidence at protein level;
KW   Acetylcholine receptor inhibiting toxin; Direct protein sequencing;
KW   Disulfide bond; Ion channel impairing toxin; Neurotoxin;
KW   Postsynaptic neurotoxin; Secreted; Toxin.
FT   CHAIN           1..>28
FT                   /note="Nicotinic acetylcholine receptor-binding protein
FT                   Mnn-3C"
FT                   /evidence="ECO:0000269|PubMed:8603741"
FT                   /id="PRO_0000408024"
FT   DISULFID        3..24
FT                   /evidence="ECO:0000250|UniProtKB:P60301"
FT   UNSURE          3
FT                   /note="Assigned by comparison with orthologs"
FT   UNSURE          17
FT                   /note="Assigned by comparison with orthologs"
FT   UNSURE          24
FT                   /note="Assigned by comparison with orthologs"
FT   NON_TER         28
SQ   SEQUENCE   28 AA;  3148 MW;  EB20ED187019C14F CRC64;
     KKCLTKYSAG LQTSQTCPAG QKICFKKW